Combining quantitative and qualitative approaches using Sequential Window Acquisition of All Theoretical Fragment-Ion methodology for the detection of pharmaceuticals and related compounds in river fish extracted using a sample miniaturized method

Peña-Herrera, J.M.; Montemurro, Nicola; Barceló, Damià; Pérez, Sandra

doi:10.1016/j.chroma.2020.461009

Cited by 15 publications

(14 citation statements)

References 62 publications

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“…Recoveries were calculated as the ratio between the peak area in the extract from spiked fish sample and the peak area in a blank fish extract. The recovery was acceptable between 70 and 130% for majority of compounds, values that fall into the range from other reported studies of pharmaceuticals validated in fish matrix [1 , 2 , 19 , 20] . The precision of the method expressed by the intra-day repeatability was calculated as the relative standard deviation (RSD%) obtained from the relative recoveries ( n = 3) for each concentration level, while the inter-day precision was determined by analyzing of the concentration levels for three consecutive days.…”

Section: Methods Validationsupporting

confidence: 69%

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Analysis of pharmaceuticals in fish using ultrasound extraction and dispersive spe clean-up on que Z-Sep/C18 followed by LC-QToF-MS detection

et al. 2020

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The presence of pharmaceutically active compounds (PhACs) in aquatic biota has been received much less attention than their presence in surface or waste water, and it was not until the mid-2000s, this gap started to be addressed. Here, we present SQUEEZe ( S olid-li Q uid U ltrasound E xtraction with Qu E Z -S e p/C18 as dispersive clean-up): a fast method for analysis of the trace 47 PhACs in fish muscle. Compared to our previously reported method [1] , it offers alternatives with improvements in recoveries, number of analytes, sample volume and solvent used. The key aspects of this method are: The ultrasound extraction was performed with acetonitrile/isopropanol 0.1% V/V formic acid. A clean-up step using QuE Z-Sep/C18 sorbents was employed to reduce lipid content of the extracts and further matrix effects in the detection of the analytes. A HPLC separation with a Kinetex EVO C18 packed column in 11 min was optimized. MS and MS/MS data were collected using SWATH acquisition on the SCIEX X500R QTOF in (+)-ESI mode. The method validated at 3 different concentrations levels: 5, 25 and 50 ng/g fish. It presented good intraday/interday reproducibility and absolute recoveries ≥ 60% for majority of analytes in composite homogenate muscle matrix of Squalius cephalus . 10 out 47 compounds were detected in fish samples.

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Section: Methods Validationsupporting

confidence: 69%

“…Owing to the fact that SWATH acquisition acquires in parallel in scan mode, it is possible to perform a retrospective analysis into the files and retrieve analytes which were not in the target list of compounds, as reported in Peña-Herrera et al. [2] .…”

Section: *Methods Detailsmentioning

confidence: 99%

Analysis of pharmaceuticals in fish using ultrasound extraction and dispersive spe clean-up on que Z-Sep/C18 followed by LC-QToF-MS detection

et al. 2020

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“…Diltiazem concentrations were less than 10 n g −1 in all matrices (brain, kidney, liver, pancreas and plasma), whereas venlafaxine was quantified in a range from 27.4 ng g −1 (skin) to 153.8 ng g −1 (brain). The presence of diltiazem has been reported by other authors [25] in the brain of fish with a Cmax of 1.5 ng g −1 and a Cmax of 34 ng g −1 in the muscle of Leuciscus cephalus captured from the Sava river in Slovenia has been reported by [5] . Othe authors [26] reported a Cmax of 20.8 ng g −1 for venlafaxine in the liver of rainbow trout exposed to undiluted effluent from a Swedish municipal WWTP for 13 days.…”

Section: Occurrence Of the Target Analytes In Fish Samplesmentioning

confidence: 75%

“…Currently, there are several analytical methods for the extraction of organic pollutants that mainly focus on their extraction in fish muscle [ [5] , [6] , [7] ] or in whole fish homogenate [ [8] , [9] , [10] ] because these can be obtained in sufficient amounts even from small species and are easy to produce, respectively. Analyzing a single tissue or homogenate fish does not allow to obtain information on the distribution of the contaminants within the organism.…”

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confidence: 99%

Development of a USE/d-SPE and targeted DIA-Orbitrap-MS acquisition methodology for the analysis of wastewater-derived organic pollutants in fish tissues and body fluids

2022

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“…Z-Sep+ is used for samples containing greater than 15% fat, and finally Z-Sep/C18 is used for samples containing less than 15% fat [167,169]. Z-Sep/C18 was used for pharmaceutical analysis from fish samples [170].…”

Section: New Sorbentsmentioning

confidence: 99%

Development of Methods for the Determination of PhACs in Soil/Earthworm/Crop System Irrigated with Reclaimed Water

Manasfi

Labad

Montemurro

2020

The Handbook of Environmental Chemistry

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Pharmaceuticals have been becoming a major concern of environmental pollution since the beginning of the century. The ways in which these contaminants are introduced into the environment are very different, but almost always associated with wastewater. In fact, current wastewater treatment plants are not designed for the removal of pharmaceutical products. Indeed, the problem of water scarcity has played an important role in the introduction of pharmaceutical products into the environment, particularly in the agricultural sector. Because of the drought, more and more countries are resorting to the use of treated wastewater to irrigate vegetables for human consumption. Consequently, the reuse of wastewater in agriculture constitutes a continuous introduction of these molecules into the soil. The effects of this practice are not entirely clear. However, the probability that these compounds can enter the food chain directly is high. In fact, through radical absorption, plants could uptake pharmaceuticals from soil and water, leading to the accumulation of drugs in the tissues. The development of analytical methods of solid matrices such as soil or plant tissues requires substantial work due to the great complexity of the matrices and the differences between the physico-chemical properties of analytes of interest. Several multi-class methods have recently been developed to determine a large number of pharmaceutical products in soil or plants using different extraction techniques. This chapter addresses to list all the analytical procedures published so far used for the extraction and analysis of pharmaceutical products from plant tissues and from the soil irrigated with treated wastewater.

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Combining quantitative and qualitative approaches using Sequential Window Acquisition of All Theoretical Fragment-Ion methodology for the detection of pharmaceuticals and related compounds in river fish extracted using a sample miniaturized method

Cited by 15 publications

References 62 publications

Analysis of pharmaceuticals in fish using ultrasound extraction and dispersive spe clean-up on que Z-Sep/C18 followed by LC-QToF-MS detection

Analysis of pharmaceuticals in fish using ultrasound extraction and dispersive spe clean-up on que Z-Sep/C18 followed by LC-QToF-MS detection

Development of a USE/d-SPE and targeted DIA-Orbitrap-MS acquisition methodology for the analysis of wastewater-derived organic pollutants in fish tissues and body fluids

Development of Methods for the Determination of PhACs in Soil/Earthworm/Crop System Irrigated with Reclaimed Water

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