Cam-follower mechanisms are key in various mechatronic applications to convert rotary to linear reciprocating motions. The dynamic behavior of these systems relies on the design parameters such as the cam shape and follower mass. It appears that for some combinations of system parameters, continuous contact between the cam and follower cannot be assured, leading to harmful periodic impacts. This research presents a data-driven approach to predict the influence of parameter settings on the system dynamics by learning from a limited data set of nominal operating conditions. More specifically, we present a hybrid model architecture encompassing an ordinary differential equation, consisting of a close interconnection of neural and physics-based network layers. Due to an increased generalization established by the physical laws, these physicsbased neural network models exhibit enhanced extrapolation capabilities compared to their black-box counterparts. Consequently, the presented models can accurately simulate the system behavior for parameter settings far beyond the nominal values included in the training data. This way, starting from a limited set of nominal time-series data, we could accurately estimate the set of critical system parameters that lead to hazardous jump phenomena in cam-follower systems.