Combining mutation and horizontal gene transfer in a within-host model of antibiotic resistance

Roberts, M. G.; Burgess, Sara; Toombs-Ruane, Leah; Benschop, Jackie; Marshall, Jonathan; French, Nigel P.

doi:10.1016/j.mbs.2021.108656

Cited by 12 publications

(12 citation statements)

References 49 publications

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“…dapat bertindak sebagai reservoir perpindahan gen resisten antibiotik dengan potensial risiko untuk mentransfer gen ini kepada bakteri patogen di dalam saluran pencernaan. Saluran pencernaan dapat bertindak sebagai reservoir perpindahan gen resisten antibiotik, dikarenakan populasi mikroorganisme pada lingkungan tersebut sangat padat, baik mikroorganisme yang resisten maupun non resisten sehingga memfasilitasi pertukaran gen resisten antara mikroorganisme di dalamnya (Josea et al, 2014;Dec et al, 2017;Preethi et al, 2017;Roberts et al, 2021).…”

Section: Pembahasanunclassified

“…Bakteri yang melakukan mutasi gen resisten antibiotik dapat bertahan terhadap 1.000 kali konsentrasi awal antibiotik. Paparan berulang terhadap antibiotik yang sama berperan dalam proses penyebaran gen resisten antibiotik secara vertikal (Roberts et al, 2021). Sementara secara horizontal, penyebaran gen resisten antibiotik dilakukan dari mikroorganisme yang telah resisten terhadap yang tidak resisten melalui mobile genetic elements seperti transposon, plasmid dan integron melalui proses transformasi, transduksi ataupun konjugasi (Burmeister 2015 dalam Devika et al, 2019).…”

Section: Pembahasanunclassified

“…Fitness cost merupakan kemampuan bakteri dalam melakukan kompetisi dengan bakteri lainnya di lingkungan yang sama. Fitness cost dipengaruhi oleh lingkungan bakteri tersebut berada (Roberts et al, 2021).…”

Section: Pembahasanunclassified

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Mekanisme Resistensi Antibiotik pada Lactobacillus dan Potensinya untuk Mengatasi Salmonellosis pada Ayam Broiler

Khoerunnisa¹,

Balia²,

Pradini³

2022

Acta Vet Indones

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Ayam broiler harus dipastikan terhindar dari penyakit zoonosis, salah satunya Salmonellosis. Resistensi Salmonella sp. terhadap berbagai antibiotik menjadi salah satu alasan dalam penggunaan probiotik sebagai pilihan alternatif untuk mengatasi Salmonellosis. Lactobacillus sp. umum digunakan sebagai probiotik untuk menanggulangi Salmonellosis pada ayam broiler. Lactobacillus sp. dapat menerima agen resisten terhadap antibiotik, baik dari lingkungan maupun di saluran pencernaan ayam. Lactobacillus sp. dapat menjadi reservoir dalam penyebaran agen resisten antibiotik. Berdasarkan hasil studi literatur, Lactobacillus sp. mampu melakukan CE (competitive exclusion) sehingga dapat mengurangi populasi bakteri patogen. Lactobacillus sp. yang diambil dari biakan, saluran pencernaan, feses, daging serta sumber air di sekitar peternakan dan rumah potong unggas memiliki sifat resisten terhadap antibiotik vankomisin, kloramfenikol, tetrasiklin dan eritromisin. Lactobacillus sp. bertindak sebagai pendonor maupun penerima gen resisten terhadap antibiotik kloramfenikol, tetrasiklin dan eritromisin yang disebarkan secara horizontal melalui konjugasi plasmid dan transposon. Lactobacillus sp. yang teridentifikasi resisten terhadap antibiotik vankomisin memiliki potensi transfer gen resisten yang rendah dikarenakan sifat resisten terhadap vankomisin merupakan resistensi instrinsik sehingga secara tidak langsung sifat tersebut sangat kecil kemungkinannya dapat disebarkan secara horizontal kepada mikroorganisme lainnya.

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Section: Pembahasanunclassified

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Mekanisme Resistensi Antibiotik pada Lactobacillus dan Potensinya untuk Mengatasi Salmonellosis pada Ayam Broiler

Khoerunnisa¹,

Balia²,

Pradini³

2022

Acta Vet Indones

View full text Add to dashboard Cite

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“…Finally, multiresistance may also occur via horizontal gene transfer between existing strains; the case was considered by Bergstrom et al [ 33 ], where the assumed multiresistance is produced at a rate proportional to M HGT = ν HGT ( R A × R B ). More detailed models of HGT, based on within host dynamics, have been studied (for example Roberts et al 's recent work [ 56 ]). For the time being, and for the sake of simplicity, we follow in the footsteps of Bergstrom et al The relative importance of each of these four channels can vary from pathogen to pathogen, and will also depend critically on antibiotic stewardship policy across the surrounding region; careful stewardship may mean that M import is minimized and we are mainly interested in de novo mutations or gene transfer.…”

Section: Introduction Of Multiresistancementioning

confidence: 99%

“…Open Sci. 9: 220181 HGT, based on within host dynamics, have been studied (for example Roberts et al's recent work [56]). For the time being, and for the sake of simplicity, we follow in the footsteps of Bergstrom et al The relative importance of each of these four channels can vary from pathogen to pathogen, and will also depend critically on antibiotic stewardship policy across the surrounding region; careful stewardship may mean that M import is minimized and we are mainly interested in de novo mutations or gene transfer.…”

Section: Introduction Of Multiresistancementioning

confidence: 99%

Comparing optimization criteria in antibiotic allocation protocols

2022

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Clinicians prescribing antibiotics in a hospital context follow one of several possible ‘treatment protocols’—heuristic rules designed to balance the immediate needs of patients against the long-term threat posed by the evolution of antibiotic resistance and multi-resistant bacteria. Several criteria have been proposed for assessing these protocols; unfortunately, these criteria frequently conflict with one another, each providing a different recommendation as to which treatment protocol is best. Here, we review and compare these optimization criteria. We are able to demonstrate that criteria focused primarily on slowing evolution of resistance are directly antagonistic to patient health both in the short and long term. We provide a new optimization criteria of our own, intended to more meaningfully balance the needs of the future and present. Asymptotic methods allow us to evaluate this criteria and provide insights not readily available through the numerical methods used previously in the literature. When cycling antibiotics, we find an antibiotic switching time which proves close to optimal across a wide range of modelling assumptions.

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Stochastic Modeling of Bacterial Population Growth with Antimicrobial Resistance

Mansour

2023

J Stat Phys

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In this paper we consider a stochastic model of bacterial population growth with antimicrobial resistance under the influence of random fluctuations. We analyze the model for the problem of persistence and extinction of bacterial cells. This analysis shows asymptotic extinction and conditional persistence for growing population. Moreover, we perform computer simulations in order to illustrate the model behavior. The model results have important implications for the eradication of bacterial cells and the emergence of resistance.

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Combining mutation and horizontal gene transfer in a within-host model of antibiotic resistance

Cited by 12 publications

References 49 publications

Mekanisme Resistensi Antibiotik pada Lactobacillus dan Potensinya untuk Mengatasi Salmonellosis pada Ayam Broiler

Mekanisme Resistensi Antibiotik pada Lactobacillus dan Potensinya untuk Mengatasi Salmonellosis pada Ayam Broiler

Comparing optimization criteria in antibiotic allocation protocols

Stochastic Modeling of Bacterial Population Growth with Antimicrobial Resistance

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