Combining multilayered wrinkled polymer SERS substrates and spectral data processing for low concentration analyte detection

Charron, Benjamin; Thibault, Vincent; Masson, Jean-François

doi:10.1007/s00216-022-04151-y

Cited by 3 publications

(4 citation statements)

References 53 publications

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“…[ 45 ] Most of the wrinkled films for SERS applications have focused on silver as material of choice; however, silver is not suitable for electrochemical detection. Furthermore, the strategies used for the fabrication of wrinkled SERS surfaces require multiple steps, and the methods used for metal deposition (e.g., thermal evaporation, [ 46 ] sputtering, [ 47 ] or electron beam evaporation [ 48 ] ) rely on costly equipment and are time intensive. More affordable alternatives involve the use of non‐conductive polymeric wrinkled surfaces, [ 49 ] which limits their application to SERS detection only.…”

Section: Resultsmentioning

confidence: 99%

Benchtop Fabricated Nano‐Roughened Microstructured Electrodes for Electrochemical and Surface‐Enhanced Raman Scattering Sensing

González‐Martínez,

Beganovic,

Moran‐Mirabal

2024

Small Methods

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Tailoring a material's surface with hierarchical structures from the micro‐ to the nanoscale is key for fabricating highly sensitive detection platforms. To achieve this, the fabrication method should be simple, inexpensive, and yield materials with a high density of surface features. Here, using benchtop fabrication techniques, gold surfaces with hierarchically structured roughness are generated for sensing applications. Hierarchical gold electrodes are prepared on pre‐stressed polystyrene substrates via electroless deposition and amperometric pulsing. Electrodes fabricated using 1 mm H[AuCl₄] and roughened with 80 pulses revealed the highest electroactive surface area. These electrodes are used for enzyme‐free detection of glucose in the presence of bovine serum albumin and achieved a limit of detection of 0.36 mm, below glucose concentrations in human blood. The surfaces nanoroughened with 100 pulses also showed excellent surface‐enhanced Raman scattering (SERS) response for the detection of rhodamine 6G, with an enhancement factor of ≈2 × 106 compared to detection in solution, and for the detection of a self‐assembled monolayer of thiophenol, with an enhancement factor of ≈30 compared to the response from microstructured gold surfaces. It is envisioned that the simplicity and low fabrication cost of these gold‐roughened structures will expedite the development of electrochemical and SERS sensing devices.

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Section: Resultsmentioning

confidence: 99%

Benchtop Fabricated Nano‐Roughened Microstructured Electrodes for Electrochemical and Surface‐Enhanced Raman Scattering Sensing

González‐Martínez,

Beganovic,

Moran‐Mirabal

2024

Small Methods

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“…1 In addition to significantly enhancing the Raman spectroscopy detection signal by amplifying the electromagnetic field generated by the surface plasmon element, surface-enhanced Raman scattering (SERS) is also capable of providing high-sensitivity structural detection of analytes with low concentrations. [2][3][4] Furthermore, SERS is becoming increasingly widely used as a powerful trace detection technology, covering a broad range of fields, such as medical safety, chemical analysis, environmental monitoring, and food testing. [5][6][7][8][9] In the initial development of SERS, substrates were limited to Au, Ag, Cu, etc., of which Ag was the most widely used because of its advantages of simplicity of preparation and relatively low cost.…”

Section: Introductionmentioning

confidence: 99%

“…It is increasingly becoming the norm to utilize optical sensing technology in modern biomedical, material, and environmental monitoring applications in comparison to other traditional methods of detection 1 . In addition to significantly enhancing the Raman spectroscopy detection signal by amplifying the electromagnetic field generated by the surface plasmon element, surface‐enhanced Raman scattering (SERS) is also capable of providing high‐sensitivity structural detection of analytes with low concentrations 2–4 . Furthermore, SERS is becoming increasingly widely used as a powerful trace detection technology, covering a broad range of fields, such as medical safety, chemical analysis, environmental monitoring, and food testing 5–9 .…”

Section: Introductionmentioning

confidence: 99%

Synthesis, characterization, and performance evaluation of polyamide‐Ag@SiO₂ Raman substrate

Wu,

Zhang,

Zhang

et al. 2024

Surface & Interface Analysis

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At present, Ag nanoparticles have been widely used as Raman substrates, but their easy oxidation and aggregation have limited practical applications. In order to address the above problems, firstly, tetraethyl orthosilicate as a precursor was applied to synthesis silver coated with silica dioxide nanoparticles (Ag@SiO2). As a result, the surface of Ag nanoparticles is uniformly coated with a thin layer of SiO2 in order to solve the easy oxidation problem without adversely affecting their surface‐enhanced Raman scattering (SERS) performance. Furthermore, Ag@SiO2 nanoparticles were electrostatically deposited onto polyamide (PA) films to form a two‐dimensional PA‐Ag@SiO2 film substrate, thus resolving nanoparticle agglomeration issues and further improving the repeatability of the entire system. As can been from the SERS detection results obtained from the probe molecules and pollutants, the Raman signal on the PA‐Ag@SiO2 thin film substrate has a good degree of sensitivity, stability, and repeatability.

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“…6,7 These can be produced by lithography, thermal evaporation, chemical etching, nanoparticle immobilization, and sputtering. 3,[8][9][10][11][12][13][14][15][16][17] These substrates are often made in-house under a clean environment to control and prevent contamination or fouling of the surfaces.…”

Section: Introductionmentioning

confidence: 99%

Bleach Cleaning of Commercially Available Gold Nanopillar Arrays for Surface-Enhanced Raman Spectroscopy (SERS)

Morder,

Schorr,

Balss

et al. 2023

Appl Spectrosc

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Surface-enhanced Raman spectroscopy (SERS) is a highly sensitive technique that can assist in trace analysis for biomedical, diagnostic, and environmental applications. However, a major limitation of SERS is surface contamination of the substrates used, which can complicate the spectral reproducibility, limits of detection, and detection of unknown analytes. This is especially prevalent with commercially available substrates as shipping under a controlled and clean environment is difficult. Here we report a method using dilute bleach solutions to remove surface contamination from commercially available substrates consisting of gold-coated nanopillar arrays that maintains functionality. The results show that this method can be used to remove background signals associated with typical surface contamination in commercially available substrates as well as remove thiolated self-assembled monolayers (SAMs). Results indicate the bleach oxidizes the surface contaminants, which can then be easily washed away. Although the metallic surface also becomes oxidized in this process, the surface can be reduced without loss of SERS activity. The SERS intensity of SAMs improved following bleach treatment across all concentrations studied.

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Combining multilayered wrinkled polymer SERS substrates and spectral data processing for low concentration analyte detection

Cited by 3 publications

References 53 publications

Benchtop Fabricated Nano‐Roughened Microstructured Electrodes for Electrochemical and Surface‐Enhanced Raman Scattering Sensing

Benchtop Fabricated Nano‐Roughened Microstructured Electrodes for Electrochemical and Surface‐Enhanced Raman Scattering Sensing

Synthesis, characterization, and performance evaluation of polyamide‐Ag@SiO₂ Raman substrate

Bleach Cleaning of Commercially Available Gold Nanopillar Arrays for Surface-Enhanced Raman Spectroscopy (SERS)

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Combining multilayered wrinkled polymer SERS substrates and spectral data processing for low concentration analyte detection

Cited by 3 publications

References 53 publications

Benchtop Fabricated Nano‐Roughened Microstructured Electrodes for Electrochemical and Surface‐Enhanced Raman Scattering Sensing

Benchtop Fabricated Nano‐Roughened Microstructured Electrodes for Electrochemical and Surface‐Enhanced Raman Scattering Sensing

Synthesis, characterization, and performance evaluation of polyamide‐Ag@SiO2 Raman substrate

Bleach Cleaning of Commercially Available Gold Nanopillar Arrays for Surface-Enhanced Raman Spectroscopy (SERS)

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Synthesis, characterization, and performance evaluation of polyamide‐Ag@SiO₂ Raman substrate