2024
DOI: 10.1101/2024.06.05.24308448
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Combining Genetic Proxies of Drug Targets and Time-to-event analyses From Longitudinal Observational Data To Identify Target Patient Populations

Luke Zhang,
Prachi Kulkarni,
Farshad Farshidfar
et al.

Abstract: BackgroundHuman genetics is an important tool for identifying genes as potential drug targets, and the extensive genetic study of cardiovascular disease provides an opportunity to leverage genetics to match specific patient populations to specific drug targets to improve prioritization of patient selection for clinical studies.MethodsWe selected well described genetic variants in the region ofPCSK9(rs11591147 and rs562556),ADRB1(rs7076938),ACE(rs4968782 and rs4363) andBAG3(rs2234962) for use as proxies for the… Show more

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