Combining functional and anatomical connectivity reveals brain networks for auditory language comprehension

Saur, Dorothee; Schelter, Björn; Schnell, Susanne; Kratochvil, D.; Küpper, Hanna; Kellmeyer, Philipp; Kümmerer, Dorothee; Klöppel, Stefan; Glauche, Volkmar; Lange, Rüdiger; Mader, Wolfgang; Feess, David; Timmer, Jens; Weiller, Cornelius

doi:10.1016/j.neuroimage.2009.11.009

Cited by 233 publications

(225 citation statements)

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“…The baseline results coincided with previous studies showing that the left IFG and STG were involved in pseudoword processing, whereas the angular gyrus, the medial and inferior temporal lobe, and the pars orbitalis of the inferior frontal gyrus were more active for words than pseudowords (Saur et al 2008(Saur et al , 2010Davis et al 2009;Rodríguez-Fornells et al 2009). In addition, activation in the STG and IFG was replicated in sessions 2 and 3 when comparing untrained pseudowords to untrained native words (see Fig.…”

Section: -Training Effects On Brain Activitysupporting

confidence: 89%

“…They also coincide with previous studies showing the relevance of the arcuate fasciculus, the white matter pathway that connects the IFG and STG, in pseudoword processing and learning. Saur et al (Saur et al 2008(Saur et al , 2010 demonstrated that the dorsal language pathway connecting two areas that resemble the IFG and STG seeds employed in the present study was associated with repetition of pseudowords, compared to repetition of real words. In addition, Lopez-Barroso et al (López-Barroso et al 2013 showed that individual differences in vocabulary acquisition correlated with the strength of the anatomical and functional connectivity of the direct connections between Broca's area and auditory brain areas in the left hemisphere (i.e.…”

Section: -Relationship Between Auditory and Motor Regions At Restmentioning

confidence: 50%

“…Auditory and motor areas communicate directly through the arcuate fasciculus (AF), a prominent white-matter tract proposed as participating in audiomotor processing in language and music (Saur et al 2008(Saur et al , 2010Halwani et al 2011). Saur et al (Saur et al 2008(Saur et al , 2010 reported that repetition of pseudowords compared to real words, activated the left anterior and posterior parts of the superior temporal region, along with frontal regions such as the left pars opercularis of the inferior frontal gyrus and the premotor areas (BA 44/6).…”

Section: Introductionmentioning

confidence: 99%

“…Saur et al (Saur et al 2008(Saur et al , 2010 reported that repetition of pseudowords compared to real words, activated the left anterior and posterior parts of the superior temporal region, along with frontal regions such as the left pars opercularis of the inferior frontal gyrus and the premotor areas (BA 44/6). In the same way, in the meta-analysis conducted by Davis and Gaskell (2009), phonological processing during unknown pseudoword processing was related to activation in the STG and opercular frontal areas, whereas processing of existing words activated more anterior, posterior and inferior regions of the lateral temporal lobe and inferior parietal regions, along with the pars orbitalis of the frontal lobe, areas related to lexical processing.…”

Section: Introductionmentioning

confidence: 99%

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The dynamic imprint of word learning on the dorsal language pathway

et al. 2017

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According to Hickok and Poeppel (2007), the acquisition of new vocabulary rests on the dorsal language pathway connecting auditory and motor areas. The present study tested this hypothesis longitudinally by measuring BOLD signal changes during a verbal repetition task and modulation of resting state functional connectivity (rs-FC) in the dorsal stream. Thirty-five healthy participants, divided into trained and control groups, completed fMRI sessions on days 1, 10, and 24. Between days 1 and 10, the trained group learned 84 new pseudowords associated with 84 native words. Task-related fMRI results showed a reduced activity in the IFG and STG while processing the learned vocabulary after training, returning to initial values two weeks later. Moreover, rs-fMRI analysis showed stronger rs-FC between the IFG and STG in the trained group than in the control group after learning, especially on day 24. These neural changes were more evident in participants with a larger vocabulary. Discussion focuses on the prominent role of the dorsal stream in vocabulary acquisition. Even when their meaning was known, newly learned words were again processed through the dorsal stream two weeks after learning, with the increase in rs-FC between auditory and motor areas being a relevant longterm imprint of vocabulary learning.

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Section: -Training Effects On Brain Activitysupporting

confidence: 89%

Section: -Relationship Between Auditory and Motor Regions At Restmentioning

confidence: 50%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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The dynamic imprint of word learning on the dorsal language pathway

et al. 2017

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“…Structurally, the ILF connects the inferior posterior temporal lobe (a region thought to serve as an "entry point" affording access to lexical and semantic representations, e.g., Damasio, Tranel, Grabowski, Adolphs, & Damasio, 2004;Démonet, Thierry, & Cardebat, 2005; see also Bedny, McGill, & Thompson-Schill, 2008), with the ATL (a region though to support semantic processing; Patterson et al, 2007;Mummery et al, 2000). Combined functional gray matter and structural white matter neuroimaging experiments of healthy subjects reveal that this pathway mediates mapping lexical with semantic representations during comprehension (Saur et al, 2008(Saur et al, , 2010Wong, Chandrasekaran, Garibaldi, & Wong, 2011). Campanella et al (2009 …”

Section: Neural Substrates Of Semantic Interference 34mentioning

confidence: 99%

Distinct loci of lexical and semantic access deficits in aphasia: Evidence from voxel-based lesion-symptom mapping and diffusion tensor imaging

Harvey

Schnur

2015

Cortex

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Please cite this article as: Harvey DY, Schnur TT, Distinct loci of lexical and semantic access deficits in aphasia: Evidence from voxel-based lesion-symptom mapping and diffusion tensor imaging, CORTEX (2015), doi: 10.1016/j.cortex.2015.03.004. This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. Further, damage to the left inferior frontal gyrus (LIFG), a region implicated in cognitive control, results in increasing semantic interference when items repeat across cycles in both language production and comprehension (Jefferies, Baker, Doran, & Lambon Ralph, 2007). This generates the prediction that the LIFG via white matter connections supports resolution of semantic interference arising from different loci (lexical vs. semantic) in the temporal lobe. However, it remains unclear whether the cognitive and neural mechanisms that resolve semantic interference are the same across tasks. Thus, we examined which gray matter structures (using whole brain and region of interest approaches) and white matter connections (using deterministic tractography) when damaged impact semantic interference and its increase across cycles when repeatedly producing and understanding words in 15 speakers with varying lexical-semantic deficits from left hemisphere stroke. We found that damage to distinct brain regions, the posterior vs. anterior temporal lobe, was associated with semantic interference (collapsed across cycles) in naming and comprehension, respectively. Further, those with LIFG damage compared to those without exhibited marginally larger increases in semantic interference across cycles in naming but not comprehension. Lastly, the inferior fronto-occipital fasciculus, connecting the LIFG with posterior temporal lobe, related to semantic interference in naming, whereas the inferior longitudinal fasciculus, connecting posterior with anterior temporal regions related to semantic interference in comprehension. These neuroanatomical-behavioral findings have

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Neural correlates of language variability in preschool‐aged boys with autism spectrum disorder

et al. 2017

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Children with autism vary widely in their language abilities, yet the neural correlates of this language variability remain unclear, especially early in development. Diffusion tensor imaging (DTI) was used to examine diffusivity measures along the length of 18 major fiber tracts in 104 preschool-aged boys with autism spectrum disorder (ASD). The boys were assigned to subgroups according to their level of language development (Low: no/low language, Middle: small vocabulary, High: large vocabulary and grammar), based on their raw scores on the expressive language (EL) and receptive language (RL) sections of the Mullen Scales of Early Learning (MSEL). Results indicate that the subgroups differed in fractional anisotropy (FA), mean diffusivity (MD), and radial diffusivity (RD) along the inferior longitudinal fasciculus (ILF) in both hemispheres. Moreover, FA correlated significantly with Mullen EL and RL raw scores, but not ADOS severity score, along the left and right ILF. Subgroups also differed in MD (but not FA) along the left superior longitudinal fasiculus and left corticospinal tract, but these differences were not correlated with language scores. These findings suggest that white matter microstructure in the left and right ILF varies in relation to lexical development in young males with ASD. The findings also support the use of raw scores on language-relevant standardized tests for assessing early language-brain relationships.

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Combining functional and anatomical connectivity reveals brain networks for auditory language comprehension

Cited by 233 publications

References 53 publications

The dynamic imprint of word learning on the dorsal language pathway

The dynamic imprint of word learning on the dorsal language pathway

Distinct loci of lexical and semantic access deficits in aphasia: Evidence from voxel-based lesion-symptom mapping and diffusion tensor imaging

Neural correlates of language variability in preschool‐aged boys with autism spectrum disorder

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