Combining drug and music therapy in patients with moderate Alzheimer’s disease: a randomized study

Giovagnoli, Anna Rita; Manfredi, Valentina; Schifano, L.; Paterlini, Chiara; Parente, Annalisa; Tagliavini, Fabrizio

doi:10.1007/s10072-018-3316-3

Cited by 48 publications

(71 citation statements)

References 44 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…A recent RCT found that music therapy added to pharmacotherapy yielded no further benefits for language and verbal communication in comparison to pharmacotherapy alone, but this integrated approach could improve the psycho-behavioral profile (225).…”

Section: Music Therapymentioning

confidence: 99%

The Multidisciplinary Approach to Alzheimer's Disease and Dementia. A Narrative Review of Non-Pharmacological Treatment

Sinforiani²,

et al. 2018

View full text Add to dashboard Cite

Background: Alzheimer's disease (AD) and dementia are chronic diseases with progressive deterioration of cognition, function, and behavior leading to severe disability and death. The prevalence of AD and dementia is constantly increasing because of the progressive aging of the population. These conditions represent a considerable challenge to patients, their family and caregivers, and the health system, because of the considerable need for resources allocation. There is no disease modifying intervention for AD and dementia, and the symptomatic pharmacological treatments has limited efficacy and considerable side effects. Non-pharmacological treatment (NPT), which includes a wide range of approaches and techniques, may play a role in the treatment of AD and dementia.Aim: To review, with a narrative approach, current evidence on main NPTs for AD and dementia.Methods: PubMed and the Cochrane database of systematic reviews were searched for studies written in English and published from 2000 to 2018. The bibliography of the main articles was checked to detect other relevant papers.Results: The role of NPT has been largely explored in AD and dementia. The main NPT types, which were reviewed here, include exercise and motor rehabilitation, cognitive rehabilitation, NPT for behavioral and psychological symptoms of dementia, occupational therapy, psychological therapy, complementary and alternative medicine, and new technologies, including information and communication technologies, assistive technology and domotics, virtual reality, gaming, and telemedicine. We also summarized the role of NPT to address caregivers' burden.Conclusions: Although NPT is often applied in the multidisciplinary approach to AD and dementia, supporting evidence for their use is still preliminary. Some studies showed statistically significant effect of NPT on some outcomes, but their clinical significance is uncertain. Well-designed randomized controlled trials with innovative designs are needed to explore the efficacy of NPT in AD and dementia. Further studies are required to offer robust neurobiological grounds for the effect of NPT, and to examine its cost-efficacy profile in patients with dementia.

show abstract

Section: Music Therapymentioning

confidence: 99%

The Multidisciplinary Approach to Alzheimer's Disease and Dementia. A Narrative Review of Non-Pharmacological Treatment

Sinforiani²,

et al. 2018

View full text Add to dashboard Cite

show abstract

“…Two articles compared MT and control group (CG) (no specific non‐pharmacological intervention) (Bingbing, 2015 ; Mariko et al., 2015 ); two articles compared IN and CG (Kudoh et al., 2009 ; Lijian, 2016 ); two articles compared RT and CG (Hatakeyama et al., 2010 ; Mo et al., 2016 ); and four articles compared TC and CG (Giovagnoli et al., 2018 ; Haiyan et al., 2016 ; Huimin et al., 2017 ; Raglio et al., 2015 ). Transitivity was maintained across treatment comparisons for the outcomes of NPI Scores (Table S3 a).…”

Section: Resultsmentioning

confidence: 99%

Comparative efficacy of non‐pharmacological interventions on behavioural and psychological symptoms in elders with dementia: A network meta‐analysis

et al. 2021

Nursing Open

View full text Add to dashboard Cite

Dementia is a progressive neurodegenerative syndrome manifested by cognitive impairment, memory loss as well as behavioural and psychological disorders, which has posed a great burden on both human health and global economy. The global rising of life expectancy and an increasing proportion of elders in the population are the main reasons for worldwide population ageing (Heese, 2015).According to the World Alzheimer Report 2018, dementia affects about 50 million people and this number is expected to increase to 152 million by 2050. Among patients with dementia, 60%-98% will develop behavioural and psychological symptoms of dementia (BPSD) (Finkel, 2000). BPSD is a wide spectrum of syndromes including mood disorders, depression, agitation, psychosis, sleep disturbances, anxiety, apathy, dysphoria, aberrant motor activity, hallucinations and delusions (Lyketsos et al., 2000).The high incidence, poor prognosis, long course of the disease and serious adverse outcomes of BPSD have brought great burdens to patients with dementia and their families, particularly economic

show abstract

“…Clinically, NDDs mainly include Alzheimer's disease (AD), Parkinson's disease (PD), Huntington's disease (HD), and amyotrophic lateral sclerosis (ALS). Neurodegenerative diseases mainly manifest as motor and cognitive dysfunction (Giovagnoli et al, 2018;Ruppert et al, 2020). Histopathological studies of these diseases have shown that neurons slowly and gradually become apoptotic, exhibit abnormal protein aggregation, and form inclusion bodies, suggesting that they may have similar disease progression mechanisms (Lau et al, 2020).…”

Section: Introductionmentioning

confidence: 99%

Involvement of Astrocytes and microRNA Dysregulation in Neurodegenerative Diseases: From Pathogenesis to Therapeutic Potential

Bai

Piao

et al. 2021

Front. Mol. Neurosci.

View full text Add to dashboard Cite

Astrocytes are the most widely distributed and abundant glial cells in the central nervous system (CNS). Neurodegenerative diseases (NDDs) are a class of diseases with a slow onset, progressive progression, and poor prognosis. Common clinical NDDs include Alzheimer’s disease (AD), Parkinson’s disease (PD), amyotrophic lateral sclerosis (ALS), and Huntington’s disease (HD). Although these diseases have different etiologies, they are all associated with neuronal loss and pathological dysfunction. Accumulating evidence indicates that neurotransmitters, neurotrophic factors, and toxic metabolites that are produced and released by activated astrocytes affect and regulate the function of neurons at the receptor, ion channel, antigen transfer, and gene transcription levels in the pathogenesis of NDDs. MicroRNAs (miRNAs) are a group of small non-coding RNAs that play a wide range of biological roles by regulating the transcription and post-transcriptional translation of target mRNAs to induce target gene expression and silencing. Recent studies have shown that miRNAs participate in the pathogenesis of NDDs by regulating astrocyte function through different mechanisms and may be potential targets for the treatment of NDDs. Here, we review studies of the role of astrocytes in the pathogenesis of NDDs and discuss possible mechanisms of miRNAs in the regulation of astrocyte function, suggesting that miRNAs may be targeted as a novel approach for the treatment of NDDs.

show abstract

Combining drug and music therapy in patients with moderate Alzheimer’s disease: a randomized study

Cited by 48 publications

References 44 publications

The Multidisciplinary Approach to Alzheimer's Disease and Dementia. A Narrative Review of Non-Pharmacological Treatment

The Multidisciplinary Approach to Alzheimer's Disease and Dementia. A Narrative Review of Non-Pharmacological Treatment

Comparative efficacy of non‐pharmacological interventions on behavioural and psychological symptoms in elders with dementia: A network meta‐analysis

Involvement of Astrocytes and microRNA Dysregulation in Neurodegenerative Diseases: From Pathogenesis to Therapeutic Potential

Contact Info

Product

Resources

About