Combining designer receptors exclusively activated by designer drugs and neuroimaging in experimental models: A powerful approach towards neurotheranostic applications

Peeters, Lore M.; Missault, Stephan; Keliris, A; Keliris, Georgios A.

doi:10.1111/bph.14885

Cited by 7 publications

(5 citation statements)

References 64 publications

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“…In this study, excitatory DREADDs were expressed in the right BFB cholinergic neurons of rats and the effects of DREADDs-induced neural activity alterations were evaluated by means of non-invasive rsfMRI. Several studies have already highlighted that the combination of the DREADDs technology and in vivo imaging techniques is an emerging powerful tool allowing scientists to advance their knowledge of brain networks in health and disease (reviewed in Peeters et al, 2019 ). Here, the excitatory DREADDs in the right BFB cholinergic neurons were activated by CNO injection and rsfMRI scans were acquired to evaluate the effect on FC and resting-state neural activity in brain regions of the DMLN.…”

Section: Discussionmentioning

confidence: 99%

Cholinergic Modulation of the Default Mode Like Network in Rats

et al. 2020

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Summary The discovery of the default mode network (DMN), a large-scale brain network that is suppressed during attention-demanding tasks, had major impact in neuroscience. This network exhibits an antagonistic relationship with attention-related networks. A better understanding of the processes underlying modulation of DMN is imperative, as this network is compromised in several neurological diseases. Cholinergic neuromodulation is one of the major regulatory networks for attention, and studies suggest a role in regulation of the DMN. In this study, we unilaterally activated the right basal forebrain cholinergic neurons and observed decreased right intra-hemispheric and interhemispheric FC in the default mode like network (DMLN). Our findings provide critical insights into the interplay between cholinergic neuromodulation and DMLN, demonstrate that differential effects can be exerted between the two hemispheres by unilateral stimulation, and open windows for further studies involving directed modulations of DMN in treatments for diseases demonstrating compromised DMN activity.

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Section: Discussionmentioning

confidence: 99%

Cholinergic Modulation of the Default Mode Like Network in Rats

et al. 2020

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“…Our study has the potential to guide future research and therapeutic strategies aimed at enhancing cognitive development and addressing neurological conditions. Future studies could consider combining pharmacological or chemogenetic approaches with neuroimaging techniques to establish connections between cellular-or molecular-level plasticity-regulating mechanisms and noninvasive human neuroimaging [89][90][91] . This integrated approach can provide further insights into specific neurobiological mechanisms underlying critical periods in the development of the human hippocampus.…”

Section: Discussionmentioning

confidence: 99%

Dual long-axis reorganization of hippocampus in youth

Zeng,

Li,

et al. 2023

Preprint

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The reorganization of human hippocampus, especially its interaction with cortex, remains largely undefined in youth. The organization of a single hippocampal long-axis has been predominantly characterized as monotonic1–6, despite recent indications of nonmonotonic features in neuron density7and geometric eigenmodes8. While the human cortical hierarchy has been well recognized for significant developmental and evolutionary advantages9–12, hippocampus has been typically considered an evolutionarily conserved brain structure1,13,14, and overlooked regarding its integrative role of cortical hierarchical processing during development. Here, we corroborated the presence and significance of a dual long-axis representation of the hippocampal connectome and geometry including both linear and quadratic gradients along its long-axis in youth. This finding was robust across two independent large-scale developmental cohorts. Charting development of the dual long-axis gradients underscored their specific contributions to the cortical hierarchy maturation from the frontoparietal and salience/ventral attention networks. The observed developmental variability in spontaneous brain activities in youth parallels the gradients of myelin content. During childhood through adolescence to early adulthood, the hippocampus reorganized the dual long-axis by gradually relaxing its geometric constraints on the intrinsic network organization of cortical spontaneous activity for refined executive functions. Molecular processes underlying such reorganization of the dual long-axis in hippocampus are linked to neural growth, stress hormone regulation, and neuroactive signaling. Our findings enrich the understanding of hippocampal-cortical reorganizational principles across structural, functional, and molecular dimensions as well as its maturation, and define the plasticity distribution within the human hippocampus at systems level, holding potentials to enhance and translate neurodevelopment and neuropsychiatric healthcare.

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“…Nanoparticles that present photochemical effects typically contain photo-responsive pendant or functional groups that induce a chemical change within the structure. This is most commonly in the form of isomerization, dimerization and bond cleavage reactions, but designer receptors exclusively activated by designer drugs (chemogenetics) and optogenetic techniques have also attracted significant interest ( Rogan and Roth, 2011 ; Peeters et al, 2020 ).…”

Section: Nanophotonic Transduction Mechanismsmentioning

confidence: 99%

Nanoparticle-based optical interfaces for retinal neuromodulation: a review

Stoddart,

Begeng,

Tong

et al. 2024

Front. Cell. Neurosci.

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Degeneration of photoreceptors in the retina is a leading cause of blindness, but commonly leaves the retinal ganglion cells (RGCs) and/or bipolar cells extant. Consequently, these cells are an attractive target for the invasive electrical implants colloquially known as “bionic eyes.” However, after more than two decades of concerted effort, interfaces based on conventional electrical stimulation approaches have delivered limited efficacy, primarily due to the current spread in retinal tissue, which precludes high-acuity vision. The ideal prosthetic solution would be less invasive, provide single-cell resolution and an ability to differentiate between different cell types. Nanoparticle-mediated approaches can address some of these requirements, with particular attention being directed at light-sensitive nanoparticles that can be accessed via the intrinsic optics of the eye. Here we survey the available known nanoparticle-based optical transduction mechanisms that can be exploited for neuromodulation. We review the rapid progress in the field, together with outstanding challenges that must be addressed to translate these techniques to clinical practice. In particular, successful translation will likely require efficient delivery of nanoparticles to stable and precisely defined locations in the retinal tissues. Therefore, we also emphasize the current literature relating to the pharmacokinetics of nanoparticles in the eye. While considerable challenges remain to be overcome, progress to date shows great potential for nanoparticle-based interfaces to revolutionize the field of visual prostheses.

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Combining designer receptors exclusively activated by designer drugs and neuroimaging in experimental models: A powerful approach towards neurotheranostic applications

Cited by 7 publications

References 64 publications

Cholinergic Modulation of the Default Mode Like Network in Rats

Cholinergic Modulation of the Default Mode Like Network in Rats

Dual long-axis reorganization of hippocampus in youth

Nanoparticle-based optical interfaces for retinal neuromodulation: a review

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