Combining CROP and ATRP to synthesize pH-responsive poly(2-ethyl-2-oxazoline-b-4-vinylpyridine) block copolymers

Abstract

Herein, we present the synthesis and characterization of block copolymers based on poly(2-ethyl-2-oxazoline), a biocompatible and stealth polymer that has drawn considerable attention in biomedical-related applications, and poly(4-vinylpyridine), a polydentate...

Hybrid Multiblock Copolymers of 2-Oxazoline and Acrylates via Cu-Catalyzed Azide–Alkyne Cycloaddition Step-Growth Mechanism

“…Therefore, this further indicates that the majority of the chains have the end-group desired. It should be noted that this end-capping reaction with BMPA and subsequent chain extension have been previously reported with styrene monomers. , The chain extension was also carried out successfully with methyl acrylate (MA) and with other PEtOx-I macroinitiators with different degrees of polymerization (25,40) (Figure S4, ESI ). The kinetic plots for the chain extension with both MA and EHA can be seen in Figure S5, ESI.…”

“…It should be noted that this end-capping reaction with BMPA and subsequent chain extension have been previously reported with styrene monomers. 11,12 The chain extension was also carried out successfully with methyl acrylate (MA) and with other PEtOx-I macroinitiators with different degrees of polymerization (25,40) (Figure S4, ESI).…”

“…8 Previous examples of this include a heterofunctional initiator that was used to combine poly(2oxazoline) with styrene 9 and poly(2-oxazoline)s end-capped with an appropriate initiator for another polymerization technique such as reversible addition−fragmentation chaintransfer polymerization (RAFT) 10 and Cu(0)-mediated reversible deactivation radical polymerization (Cu(0)-RDRP). 11,12 Furthermore, different chemistries of each polymer block can lead to interesting physical behavior such as amphiphilicity. 13 Frequently, post-polymerization click reactions such as the thiol−ene reaction 14 and copper(I)-catalyzed azide−alkyne cycloaddition (CuAAC) 15,16 are used as simple techniques to access higher orders of polymeric architecture such as stars, 17 brushes, 18 cyclic polymers, 19 and multiblock polymers.…”

“…Additionally, the side group of 2-oxazoline can be utilized to introduce functional groups, which allow for tuning the physical properties of the polymer. , Poly­(2-oxazoline)­s can further be functionalized by combination with other types of polymerization technique . Previous examples of this include a heterofunctional initiator that was used to combine poly­(2-oxazoline) with styrene and poly­(2-oxazoline)­s end-capped with an appropriate initiator for another polymerization technique such as reversible addition–fragmentation chain-transfer polymerization (RAFT) and Cu(0)-mediated reversible deactivation radical polymerization (Cu(0)-RDRP). , Furthermore, different chemistries of each polymer block can lead to interesting physical behavior such as amphiphilicity …”

Síntese e caracterização de cápsulas poliméricas responsivas

“…A PEtOx, cuja estrutura química está apresentada na Figura 6, é um polímero que tem despertado grande interesse nas últimas décadas, devido a sua hidrofilicidade, biocompatibildiade, termorresponsividade (a depender da massa molar) e seu comportamento stealth (isto é, apresenta tempo prolongado de circulação nos fluidos corpóreos por ser biologicamente inerte) [50][51][52] 51,55 , o que permite a síntese de polímeros de diversas arquiteturas 50 , a copolimerização (simultânea, ou não) empregando outras técnicas de polimerização 27 , a condução de reações de funcionalização pós-polimerização 56,57 , bem como a síntese de macroiniciadores de PEtOx para a obtenção de copolímeros em bloco e de poliuretanas 58,59 .…”