Combining adult stem cells and polymeric devices for tissue engineering in infarcted myocardium

Karam, Jean‐Pierre; Muscari, Claudio; Montero‐Menei, Claudia N.

doi:10.1016/j.biomaterials.2012.04.028

Cited by 96 publications

(76 citation statements)

References 186 publications

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“…These new biomaterials are biocompatible and biodegradable polymers made of poly (d, l-lactide-co-glycolide acid) or poly(lactic-co-glycolic acid) that allow prolonged and controlled delivery of growth factors in situ and better cell retention in the transplanted area. [120][121][122] The combination of the stem cells, biomaterials and growth factors may enhance the efficacy of cell therapy by mobilizing endogenous stem/progenitor cells in vivo, promoting cell proliferation and differentiation, and augmenting cell engraftment and survival in the injured myocardium [120][121][122] (Figure). Likewise, transplantation of AT-MSCs coated on fibrin polymers and CPCs with immobilized insulin growth factor type 1 on peptide nanofibers has been shown to be beneficial.…”

Section: Novel Delivery Systems For Stem Cell Therapymentioning

confidence: 99%

Recent Developments in Cardiovascular Stem Cells

Madonna

Ferdinándy

Caterina

et al. 2014

Circulation Research

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45Human embryonic stem cells have been shown to differentiate to beating cardiomyocytes, SA nodal-like cells and mesodermal Recent Developments in Cardiovascular Research:The goal of "Recent Developments" is to provide a concise but comprehensive overview of new advances in cardiovascular research, which we hope will keep our readers abreast of recent scientific discoveries and facilitate discussion, interpretation, and integration of the findings. This will enable readers who are not experts in a particular field to grasp the significance and effect of work performed in other fields. It is our hope and expectation that these "Recent Development" articles will help readers to gain a broader awareness and a deeper understanding of the status of research across the vast landscape of cardiovascular research-The Editors. 50 Moreover, the use of induced pluripotent stem cell-derived cardiac myocytes for cardiac repair is hampered by their immature phenotype and the presence of epigenetic and genetic changes.24,51,52 Resident and bone marrow cells and cortical bone-derived cells are considered as potential sources for differentiation to cardiac myocytes but lacking compelling evidence for cardiac myogenesis and perhaps exerting their salutary biological effects through paracrine mechanisms. 19,29,[53][54][55][56][57][58] Equally exciting and challenging are the discovery and characterization of other CPCs that could give raise to various cardiac cells types, including smooth muscle cells, endothelial cells, and fibroblasts. [59][60][61][62][63] An important problem to overcome is the multiple comorbidities and their comedications of ischemic heart disease patients with heart failure that may affect cytoprotective signaling triggered by the different stem cell, as well as survival and differentiation properties of such stem cells in the injured tissue. [64][65][66] Clearly, the rapid face of discoveries is dazzling and a complete coverage of the recent developments in cardiovascular stem cells would be beyond the scope of this article. We regret that many valuable works were not covered in part or at all included in the present overview on Recent Developments. Clinical Trials In Human PatientsThe ClinicalTrials.gov lists >1000 clinical trials including >600 studies in the United States alone that tests effects of various stem cells in human patients (http://www.clinicaltrials. gov/). The list includes 71 including 38 active clinical trials in patients with heart failure using various stem cells, such as adipose-derived, mesenchymal, human embryonic, autologous CD133 + and CD34 + stem cells among the others.18,67-74Autologous skeletal myoblasts were probably the first cell type used to regenerate functional myocardium. It was tested initially in a rabbit model of myocardial cryoinjury, which showed incorporation of the injected myoblasts and improved myocardial performance. 75 Subsequent observational studies were followed by randomized clinical trials in human patients with heart failure injected with autologous skele...

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Section: Novel Delivery Systems For Stem Cell Therapymentioning

confidence: 99%

Recent Developments in Cardiovascular Stem Cells

Madonna

Ferdinándy

Caterina

et al. 2014

Circulation Research

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“…Polymeric matrices aim at providing a favorable environment for ex vivo cell adhesion and growth, and for facilitated implantation onto the ischemic myocardium [4,[8][9][10][11][12][13].…”

Section: Introductionmentioning

confidence: 99%

Plasma-functionalized electrospun matrix for biograft development and cardiac function stabilization

et al. 2014

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Cardiac tissue engineering approaches can deliver large numbers of cells to the damaged myocardium and have thus increasingly been considered as a possible curative treatment to counteract the high prevalence of progressive heart failure after myocardial infarction (MI). Optimal scaffold architecture and mechanical and chemical properties, as well as immune-and bio-compatibility, need to be addressed. We demonstrated that radio-frequency plasma surface functionalized electrospun poly (e-caprolactone) (PCL) fibres provide a suitable matrix for bone-marrow-derived mesenchymal stem cell (MSC) cardiac implantation. Using a rat model of chronic MI, we showed that MSC-seeded plasma-coated PCL grafts stabilized cardiac function and attenuated dilatation. Significant relative decreases of 13% of the ejection fraction (EF) and 15% of the fractional shortening (FS) were observed in sham treated animals; respective decreases of 20% and 25% were measured 4 weeks after acellular patch implantation, whereas a steadied function was observed 4 weeks after MSC-patch implantation (relative decreases of 6% for both EF and FS).

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“…Currently, large number of researchers is working on incorporation of stem cells with scaffolds and proteins as a method of delivery of stem cells, to ensure mechanical support and increase cell survival, as well as growth factors to guide stem cell differentiation. Change in strategy has already given better outcomes, and latest research on cardiac regeneration using releasing and structural scaffolds and adult stem cells is giving promising results [19,20].…”

Section: Stem Cell Therapymentioning

confidence: 99%

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Combining adult stem cells and polymeric devices for tissue engineering in infarcted myocardium

Cited by 96 publications

References 186 publications

Recent Developments in Cardiovascular Stem Cells

Recent Developments in Cardiovascular Stem Cells

Plasma-functionalized electrospun matrix for biograft development and cardiac function stabilization

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