Combining a supervised and home-based task-oriented circuit training improves walking endurance in patients with multiple sclerosis. The MS_TOCT randomized-controlled trial

Straudi, Sofía; Marco, Gianluca De; Martinuzzi, Carlotta; Baroni, A.; Lamberti, Nicola; Brondi, Laura; Roit, Marco Da; Pizzongolo, Laura Di Marco; Basaglia, Nino; Manfredini, Fabio

doi:10.1016/j.msard.2022.103721

Cited by 10 publications

(24 citation statements)

References 44 publications

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“…Twenty-five interventions were supervised in-person, 16,36,48,49,51–55,57,60,63,64,67,70,73–79,82,84,85 three interventions were completed independently by participants, with minimal researcher input, 59,66,72 three interventions included remote supervision, 58,68,71 three interventions included both supervised and independent exercise throughout, 56,61,62 and seven interventions began supervised and progressed to independent exercise. 50,61,65,69,80,81,83…”

Section: Resultsmentioning

confidence: 99%

“…Participants had primarily mild MS disability in 22 (55%) studies, 16,36,[48][49][50]53,56,58,61,63,64,68,[72][73][74][75][76][77]79,84,85 primarily moderate MS disability in nine (23%) studies 51,54,60,65,66,69,[81][82][83] and primarily severe MS disability in 3 (8%) studies. 52,55,62 Participants had mild and moderate MS disability in three (8%) studies, 59,70,71 and two studies did not report disability level.…”

Section: Study Characteristicsmentioning

confidence: 99%

“…52,55,62 Participants had mild and moderate MS disability in three (8%) studies, 59,70,71 and two studies did not report disability level. 57,78 Participants primarily had a relapsing remitting MS phenotype in 6 (15%) studies 36,51,53,61,68,79 and all MS phenotypes in 20 (50%) studies; 48,50,52,54,56,[62][63][64]66,67,69,71,72,74,[80][81][82][83][84] MS phenotype was not reported in 13 (33%) studies. 16,49,[57][58][59][60]65,70,73,75,77,78,85 Participants had been diagnosed with MS for less than 5 years in two studies, 60,67 between 5 and 10 years in nine (23%) studies …”

Section: Study Characteristicsmentioning

confidence: 99%

“…Prescribed intensity varied across studies. Nine aerobic, 49,52,53,58,64,65,73,77,79 2 resistance, 54,72 16 combined 16,50,56,57,61,63,[68][69][70][71]74,76,78,80,82,84 and 7 neuromotor 54,55,59,60,75,83,85 exercise interventions were included. Eight other exercise interventions did not meet these criteria types of exercise and were classified as 'other'.…”

Section: Study Characteristicsmentioning

confidence: 99%

“…Twentyfive interventions were supervised in-person, 16,36,48,49,[51][52][53][54][55]57,60,63,64,67,70,[73][74][75][76][77][78][79]82,84,85 three interventions were completed independently by participants, with minimal researcher input, 59,66,72 three interventions included remote supervision, 58,68,71 three interventions included both supervised and independent exercise throughout, 56,61,62 and seven interventions began supervised and progressed to independent exercise. 50,61,65,69,80,81,83 Safety criteria Rate of events. Our systematic search for relevant studies indicated that many (n = 50) studies were excluded for unclear or missing safety reporting (Supplemental reference list).…”

Section: Study Characteristicsmentioning

confidence: 99%

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Safety of exercise training in multiple sclerosis: An updated systematic review and meta-analysis

Learmonth,

P Herring,

Russell

et al. 2023

Mult Scler

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Background: A review of the safety profile of exercise training in multiple sclerosis (MS) has not been conducted since 2013. Objective: We undertook a systematic review and meta-analysis of randomised controlled trials (RCTs) of exercise training published since 2013 and quantified estimated population risks of clinical relapse, adverse events (AE) and serious adverse event (SAE). Methods: Articles reporting safety outcomes from comparisons of exercise training with non-exercise among persons with MS were identified. The risk of bias was established from study’s internal validity assessed using Physiotherapy Evidence Database (PEDro). Rates and estimated mean population relative risks (RRs; 95% confidence interval (CI)) of safety outcomes were calculated, and random-effects meta-analysis estimated the mean RR. Results: Forty-six interventions from 40 RCTs ( N = 1780) yielded 46, 40 and 39 effects for relapse, AE, adverse effects and SAE, respectively. The mean population RRs ((95% CI), p-value) for relapse, AE and SAE were 0.95 ((0.61, 1.48), p = 0.82), 1.40 ((0.90, 2.19), p = 0.14) and 1.05 ((0.62, 1.80), p = 0.85), respectively. No significant heterogeneity is observed for any outcome. Conclusion: In studies that reported safety outcomes, there was no higher risk of relapse, AE, adverse effects or SAE for exercise training than the comparator. Exercise training may be promoted as safe and beneficial to persons with MS.

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