Combing databases reveals potential antibiotic producers

Kalia, Vipin Chandra; Rani, Asha; Lal, Sadhana; Cheema, Simrita; Raut, Chandrajit P.

doi:10.1517/17460441.2.2.211

Cited by 29 publications

(20 citation statements)

References 51 publications

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“…The high frequency of evolution of multidrug resistant bacteria has deterred scientific community involved in developing novel antibiotics. So much so that pharmaceutical companies are hesitant to make any financial investments [157][158][159]. It's rightly said, as mentioned before that to counter environmental constraints and natural selection bacterial pathogenicity has to and will evolve over time and inhibition of QS has been gauged as the ticket out of this scramble.…”

Section: Oc8hslmentioning

confidence: 99%

Potential Emergence of Multi-quorum Sensing Inhibitor Resistant (MQSIR) Bacteria

et al. 2015

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Expression of certain bacterial genes only at a high bacterial cell density is termed as quorum-sensing (QS). Here bacteria use signaling molecules to communicate among themselves. QS mediated genes are generally involved in the expression of phenotypes such as bioluminescence, biofilm formation, competence, nodulation, and virulence. QS systems (QSS) vary from a single in Vibrio spp. to multiple in Pseudomonas and Sinorhizobium species. The complexity of QSS is further enhanced by the multiplicity of signals: (1) peptides, (2) acyl-homoserine lactones, (3) diketopiperazines. To counteract this pathogenic behaviour, a wide range of bioactive molecules acting as QS inhibitors (QSIs) have been elucidated. Unlike antibiotics, QSIs don't kill bacteria and act at much lower concentration than those of antibiotics. Bacterial ability to evolve resistance against multiple drugs has cautioned researchers to develop QSIs which may not generate undue pressure on bacteria to develop resistance against them. In this paper, we have discussed the implications of the diversity and multiplicity of QSS, in acting as an arsenal to withstand attack from QSIs and may use these as reservoirs to develop multi-QSI resistance.

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Section: Oc8hslmentioning

confidence: 99%

Potential Emergence of Multi-quorum Sensing Inhibitor Resistant (MQSIR) Bacteria

et al. 2015

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“…It is now believed that microbes have the potential arsenal necessary to counter almost all conceivable antibiotics. So much so that pharmaceutical industry is finding it counter productive to invest in this area [1]. It has pushed researchers to the edge and forced them to have a re-look on the ways to attack microbes.…”

mentioning

confidence: 99%

Microbes, Antimicrobials and Resistance: The Battle Goes On

Kalia

2013

Indian J Microbiol

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“…In this post genomic era, the availability of 940 bacterial, 48 archaeal and 162 eukaryotic sequenced genomes (http://www.ncbi.nlm.nih.gov/sutils/genom_ table.cgi), has infact "fl ooded" us with a large amount of data. With the use of bioinformatics tools, it has been possible to detect novel organisms with properties such as H 2 -, PHA-, antibiotic-production [144][145][146]. These studies have also revealed those organisms, which are at present categorized as "non"-producers, because they lack a gene or two of the biosynthetic pathway.…”

Section: Exploiting Natural Hgt For Engineering Biosynthetic Pathwaysmentioning

confidence: 99%

Phylogeny vs genome reshuffling: horizontal gene transfer

2008

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The evolutionary events in organisms can be tracked to the transfer of genetic material. The inheritance of genetic material among closely related organisms is a slow evolutionary process. On the other hand, the movement of genes among distantly related species can account for rapid evolution. The later process has been quite evident in the appearance of antibiotic resistance genes among human and animal pathogens. Phylogenetic trees based on such genes and those involved in metabolic activities refl ect the incongruencies in comparison to the 16S rDNA gene, generally used for taxonomic relationships. Such discrepancies in gene inheritance have been termed as horizontal gene transfer (HGT) events. In the post-genomic era, the explosion of known sequences through large-scale sequencing projects has unraveled the weakness of traditional 16S rDNA gene tree based evolutionary model. Various methods to scrutinize HGT events include atypical composition, abnormal sequence similarity, anomalous phylogenetic distribution, unusual phyletic patterns, etc. Since HGT generates greater genetic diversity, it is likely to increase resource use and ecosystem resilience.

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Combing databases reveals potential antibiotic producers

Cited by 29 publications

References 51 publications

Potential Emergence of Multi-quorum Sensing Inhibitor Resistant (MQSIR) Bacteria

Potential Emergence of Multi-quorum Sensing Inhibitor Resistant (MQSIR) Bacteria

Microbes, Antimicrobials and Resistance: The Battle Goes On

Phylogeny vs genome reshuffling: horizontal gene transfer

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