Combined X-ray radiotherapy and laser photothermal therapy of melanoma cancer cells using dual-sensitization of platinum nanoparticles

Daneshvar, Fatemeh; Salehi, Fatemeh; Karimi, Maryam; Vais, R. Dehdari; Mosleh-Shirazi, Mohammad Amin; Sattarahmady, N.

doi:10.1016/j.jphotobiol.2019.111737

Cited by 58 publications

(24 citation statements)

References 56 publications

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“…Platinum nanoparticles (PtNPs) have also been used in preclinical trials. They showed good biocompatibility, as well as anti-inflammatory effects due to their enzymatic properties against reactive oxygen species [15,16].…”

Section: Inorganic Nanoparticlesmentioning

confidence: 99%

“…Inadequate tumoral vascularization, hypoxia, and deficiencies of radiation absorption may limit the effect of radiotherapy [15]. Metal nanostructures, used as radiosensitizers, could improve the therapeutic action against melanoma.…”

Section: Radiation Therapymentioning

confidence: 99%

“…Metal nanostructures, used as radiosensitizers, could improve the therapeutic action against melanoma. Several studies showed promising effects of AuNPs and PtNPs on X-ray absorption, as well as the efficacy against cancer cells [15,16].…”

Section: Radiation Therapymentioning

confidence: 99%

“…Daneshvar F. et al (2019) combined X-ray radiotherapy with 808 nm diode laser photothermal therapy of melanoma B16/F10cells after their sensitization with PtNPs [15]. They observed an enhanced therapeutic action, with the efficient death of cancer cells [15].…”

Section: Radiation Therapymentioning

confidence: 99%

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Nanosystems for Improved Targeted Therapies in Melanoma

Beiu

Giurcăneanu

Grumezescu

et al. 2020

JCM

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Melanoma is one of the most aggressive forms of skin cancer, with limited therapeutic options. Since its incidence has been rapidly rising in recent years, the study of new targeted therapeutic strategies has increased. The implication of nanoscience in the development of alternative targeted therapies for melanoma has multiple benefits and could significantly improve the outcome of melanoma patients. In this paper, we review the most recent progress in the field of targeted therapies, emphasizing the impact of nanoscale materials on the targeting and controlled release of anti-tumor drugs. The applications of nanomedicine in the management of melanoma are extensive and refer to sentinel lymph node mapping, chemotherapy, and RNA interference; each of these applications harboring the potential to develop efficient and personalized diagnostic techniques and therapies. Further research, especially in clinical trials, is needed to establish whether fighting melanoma on the nanoscale level represents the key to reaching a critical inflection point in mankind’s battle with metastatic melanoma.

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Section: Inorganic Nanoparticlesmentioning

confidence: 99%

Section: Radiation Therapymentioning

confidence: 99%

Section: Radiation Therapymentioning

confidence: 99%

Section: Radiation Therapymentioning

confidence: 99%

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Nanosystems for Improved Targeted Therapies in Melanoma

Beiu

Giurcăneanu

Grumezescu

et al. 2020

JCM

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“…While platinum (Z = 78) nanoparticles also fulfill the necessary criteria for achieving a radiation enhancement effect, the literature is still scarce. Most studies have focused on very small Pt nanoparticles [3][4][5][6][7][8], while few have focused on larger and more complex structures, such as nanoflowers [9], nanodendrites [10,11], and bimetallic nanoparticles [12].…”

Section: Introductionmentioning

confidence: 99%

Radiation Enhancer Effect of Platinum Nanoparticles in Breast Cancer Cell Lines: In Vitro and In Silico Analyses

Hullo

Grall

Perrot

et al. 2021

IJMS

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High-Z metallic nanoparticles (NPs) are new players in the therapeutic arsenal against cancer, especially radioresistant cells. Indeed, the presence of these NPs inside malignant cells is believed to enhance the effect of ionizing radiation by locally increasing the dose deposition. In this context, the potential of platinum nanoparticles (PtNPs) as radiosensitizers was investigated in two breast cancer cell lines, T47D and MDA-MB-231, showing a different radiation sensitivity. PtNPs were internalized in the two cell lines and localized in lysosomes and multivesicular bodies. Analyses of cell responses in terms of clonogenicity, survival, mortality, cell-cycle distribution, oxidative stress, and DNA double-strand breaks did not reveal any significant enhancement effect when cells were pre-exposed to PtNPs before being irradiated, as compared to radiation alone. This result is different from that reported in a previous study performed, under the same conditions, on cervical cancer HeLa cells. This shows that the efficacy of radio-enhancement is strongly cell-type-dependent. Simulation of the early stage ionization processes, taking into account the irradiation characteristics and realistic physical parameters in the biological sample, indicated that PtNPs could weakly increase the dose deposition (by 3%) in the immediate vicinity of the nanoparticles. Some features that are potentially responsible for the biological effect could not be taken into account in the simulation. Thus, chemical and biological effects could explain this discrepancy. For instance, we showed that, in these breast cancer cell lines, PtNPs exhibited ambivalent redox properties, with an antioxidant potential which could counteract the radio-enhancement effect. This work shows that the efficacy of PtNPs for enhancing radiation effects is strongly cell-dependent and that no effect is observed in the case of the breast cancer cell lines T47D and MDA-MB-231. Thus, more extensive experiments using other relevant biological models are needed in order to evaluate such combined strategies, since several clinical trials have already demonstrated the success of combining nanoagents with radiotherapy in the treatment of a range of tumor types.

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Biomedical Applications of MXene‐Integrated Composites: Regenerative Medicine, Infection Therapy, Cancer Treatment, and Biosensing

Maleki

Ghomi

Nikfarjam

et al. 2022

Adv Funct Materials

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MXenes (viz., transition metal carbides, carbonitrides, and nitrides) have emerged as a new subclass of 2D materials. Due to their outstanding physicochemical and biological properties, MXenes have gained much attention in the biomedical field in recent years, including drug delivery systems, regenerative medicine, and biosensing. Additionally, the incorporation of MXenes into hydrogels has garnered significant interest in biomedical engineering as an electroactive and mechanical nanoreinforcer capable of converting nonconductive scaffolds into excellent conductors of electricity with an impressive effect on mechanical properties for the engineering of electroactive organs and tissues such as cardiac, skeletal muscle, and nerve. However, many questions and problems remain unresolved that need to be answered to usher these 2D materials toward their true destiny. Thus, this review paper aims to provide an overview of the design and applications of MXene-integrated composites for biomedical applications, including cardiac tissue engineering, wound healing, infection therapy, cancer therapy, and biosensors. Moreover, the current challenges and limitations of utilizing MXenes in vivo are highlighted and discussed, followed by its prospects as a guideline toward possible various futuristic biomedical applications. This review article will inspire researchers, who search for properties, opportunities, and challenges of using this 2D nanomaterial in biomedical applications.

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Combined X-ray radiotherapy and laser photothermal therapy of melanoma cancer cells using dual-sensitization of platinum nanoparticles

Cited by 58 publications

References 56 publications

Nanosystems for Improved Targeted Therapies in Melanoma

Nanosystems for Improved Targeted Therapies in Melanoma

Radiation Enhancer Effect of Platinum Nanoparticles in Breast Cancer Cell Lines: In Vitro and In Silico Analyses

Biomedical Applications of MXene‐Integrated Composites: Regenerative Medicine, Infection Therapy, Cancer Treatment, and Biosensing

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