Combined vitamin D and magnesium supplementation does not influence markers of bone turnover or glycemic control: A randomized controlled clinical trial

Dall, Rosemary DeLuccia; Cheung, May; Shewokis, Patricia A.; Altasan, Asma; Volpe, Stella L.; Amori, Renee; Singh, Harpreet; Sukumar, Deeptha

doi:10.1016/j.nutres.2022.12.005

Cited by 2 publications

(1 citation statement)

References 80 publications

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“…Mg 2+ acts as a co-factor to promote OB cell attachment, differentiation, and mineralization [ 89 ], approximately 60% of which is deposited in bone. Altering the magnesium status of the body may be regulated by direct stimulation of OB proliferation and differentiation or indirect effects on the major regulators of calcium homeostasis (PTH, vitamin D) [ 90 ], but no short-term effects of magnesium were found in a study evaluating the effects of magnesium in conjunction with vitamin D on glycemic and bone turnover markers in obese or overweight patients [ 91 ].…”

Section: Macronutrients and Micronutrientsmentioning

confidence: 99%

Nutritional therapy bridges the critical cut-off point for the closed-loop role of type 2 diabetes and bone homeostasis: A narrative review

Zeng,

Qian,

Yang

et al. 2024

Heliyon

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Section: Macronutrients and Micronutrientsmentioning

confidence: 99%

Nutritional therapy bridges the critical cut-off point for the closed-loop role of type 2 diabetes and bone homeostasis: A narrative review

Zeng,

Qian,

Yang

et al. 2024

Heliyon

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Prediabetes and insulin resistance: effect of vitamin D

Kawahara

2024

Current Opinion in Clinical Nutrition &Amp; Metabolic Care

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Purpose of review The impact of vitamin D on improving insulin resistance in prediabetes remains controversial. The purpose of this review is to examine whether vitamin D supplementation improves insulin resistance in adults with prediabetes, and if so, to identify the mechanisms and the specific populations. Recent findings Global prevalence of prediabetes is increasing, and prevention is a critical issue because these people with prediabetes will develop type 2 diabetes soon, which will put pressure on healthcare costs. Recent evidence on the effectiveness of vitamin D administration in improving insulin resistance and preventing the onset of type 2 diabetes in adults with prediabetes has been accumulating. The 2024 updated clinical practice guideline of the American Diabetes Association states that vitamin D administration to patients with prediabetes potentially benefits type 2 diabetes incidence in specific populations. There are also reports that vitamin D administration improves insulin resistance via increased serum osteocalcin levels, a marker of bone turnover. Summary Vitamin D is likely to improve insulin resistance, which is already present at the time of prediabetes. However, the effectiveness may vary depending on ethnic differences and blood vitamin D levels at the start of administration.

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Combined vitamin D and magnesium supplementation does not influence markers of bone turnover or glycemic control: A randomized controlled clinical trial

Cited by 2 publications

References 80 publications

Nutritional therapy bridges the critical cut-off point for the closed-loop role of type 2 diabetes and bone homeostasis: A narrative review

Nutritional therapy bridges the critical cut-off point for the closed-loop role of type 2 diabetes and bone homeostasis: A narrative review

Prediabetes and insulin resistance: effect of vitamin D

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