Combined Vitamin C and E Supplementation for the Prevention of Preeclampsia: A Systematic Review and Meta-Analysis

Başaran, Ahmet; Başaran, Mustafa; Topatan, Betül

doi:10.1097/ogx.0b013e3182095366

Cited by 48 publications

(25 citation statements)

References 32 publications

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“…However, clinical trials of vitamins C and E showed no reduction in incidence of pre-eclampsia for women at risk [116,117]. This has been confirmed with systematic reviews and meta-analyses of trials evaluating a combination of these vitamins [118,119]. Importantly, questions relating to safety of administration of vitamins C and E have been raised.…”

Section: Potential Novel Therapiesmentioning

confidence: 75%

Hypertension in Pregnancy: Natural History and Treatment Options

et al. 2015

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Hypertensive disorders of pregnancy affect approximately 5-10% of all maternities and are major contributors of maternal and neonatal morbidity and mortality worldwide. This group of disorders encompasses chronic hypertension, as well as conditions that arise de novo in pregnancy: gestational hypertension and pre-eclampsia. The latter group is thought to be part of the same continuum but with arbitrary division. Research into the aetiology of hypertension in pregnancy have largely been focused on pre-eclampsia, with a majority of studies exploring either pregnancy-associated factors such as placental-derived or immunologic responses to pregnancy tissue, or maternal constitutional factors such as cardiovascular health and endothelial dysfunction. The evidence base for the pathophysiology and progression of hypertensive disorders in pregnancy, particularly pre-eclampsia, is reviewed. Clinical algorithms and pharmacological agents for the management of hypertension in pregnancy are summarised, with a brief focus on post-partum considerations and long-term health implications. Novel therapeutic options for the management of pre-eclampsia are also explored.

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Section: Potential Novel Therapiesmentioning

confidence: 75%

Hypertension in Pregnancy: Natural History and Treatment Options

et al. 2015

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“…While a potential risk of larger doses of vitamins C and E on increasing the risk of small for gestational age delivery has been discussed, a systematic review on effects of combined vitamin C and E supplementation during pregnancy suggests no effects on the prevention of foetal or neonatal death, poor foetal growth, preterm birth or pre-eclampsia. It did not detect any effects on the risks of preeclampsia, foetal or neonatal loss, or small for gestational age infants [76].…”

Section: Recommendations On Nutrition Of Pregnant Womenmentioning

confidence: 99%

Nutrition During Pregnancy, Lactation and Early Childhood and its Implications for Maternal and Long-Term Child Health: The Early Nutrition Project Recommendations

et al. 2019

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Background: A considerable body of evidence accumulated especially during the last decade, demonstrating that early nutrition and lifestyle have long-term effects on later health and disease (“developmental or metabolic programming”). Methods: Researchers involved in the European Union funded international EarlyNutrition research project consolidated the scientific evidence base and existing recommendations to formulate consensus recommendations on nutrition and lifestyle before and during pregnancy, during infancy and early childhood that take long-term health impact into account. Systematic reviews were performed on published dietary guidelines, standards and recommendations, with special attention to long-term health consequences. In addition, systematic reviews of published systematic reviews on nutritional interventions or exposures in pregnancy and in infants and young children aged up to 3 years that describe effects on subsequent overweight, obesity and body composition were performed. Experts developed consensus recommendations incorporating the wide-ranging expertise from additional 33 stakeholders. Findings: Most current recommendations for pregnant women, particularly obese women, and for young children do not take long-term health consequences of early nutrition into account, although the available evidence for relevant consequences of lifestyle, diet and growth patterns in early life on later health and disease risk is strong. Interpretation: We present updated recommendations for optimized nutrition before and during pregnancy, during lactation, infancy and toddlerhood, with special reference to later health outcomes. These recommendations are developed for affluent populations, such as women and children in Europe, and should contribute to the primary prevention of obesity and associated non-communicable diseases.

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“…Several randomized studies of the efficacy of antioxidant vitamins in preventing preeclampsia have shown no beneficial effects of vitamin C and E supplementation during pregnancy with respect to reducing the risk of preeclampsia. [11][12][13][14][15] Intriguingly, epidemiological studies have reported a decreasing trend in the incidence of severe preeclampsia among patients with a high dietary intake of vitamin C and increased plasma vitamin C levels. 16,17 During the first trimester, the intervillous space of the developing placenta is separated from the uterine circulation by plugs of trophoblasts that occlude the tips of uteroplacental arteries.…”

Section: Introductionmentioning

confidence: 99%

Vitamin C Induces the Reduction of Oxidative Stress and Paradoxically Stimulates the Apoptotic Gene Expression in Extravillous Trophoblasts Derived From First-Trimester Tissue

et al. 2015

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Aim: To investigate the effects of vitamin C on the expression of the genes related to apoptosis in extravillous trophoblasts (EVTs) in the first trimester. Methods: Extravillous trophoblasts were cultured under 2% O 2 followed by 2% O 2 or 8% O 2 with or without vitamin C. The level of reactive oxygen species (ROS) in the cultured medium was estimated using electron spin resonance spectroscopy. The expression levels of the genes TP53, BCL2, and BAX were quantified using real-time quantitative polymerase chain reaction. Results: Reactive oxygen species were found to be decreased after adding vitamin C under increasing oxygen concentrations. In addition, the ratio of BAX/BCL2 also increased after adding vitamin C under conditions of 2% O 2 , while the gene expression level of BCL2 increased after adding vitamin C under increasing oxygen concentrations. In contrast, the gene expression level of TP53 and the ratio of BAX/BCL2 both decreased. Conclusion: We have revealed that vitamin C reduces ROS and may promote the apoptosis of EVTs under conditions of 2% O 2 while paradoxically preventing apoptosis under increasing oxygen concentrations.

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Combined Vitamin C and E Supplementation for the Prevention of Preeclampsia: A Systematic Review and Meta-Analysis

Abstract: Obstetricians & Gynecologists, Family Physicians.

Cited by 48 publications

References 32 publications

Hypertension in Pregnancy: Natural History and Treatment Options

Hypertension in Pregnancy: Natural History and Treatment Options

Nutrition During Pregnancy, Lactation and Early Childhood and its Implications for Maternal and Long-Term Child Health: The Early Nutrition Project Recommendations

Vitamin C Induces the Reduction of Oxidative Stress and Paradoxically Stimulates the Apoptotic Gene Expression in Extravillous Trophoblasts Derived From First-Trimester Tissue

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