Combined Ventilation-Perfusion Scintigraphy for Demonstration of Pulmonary Embolism

Kiil, J; Jensen, F. T.

doi:10.1177/028418517902000311

Cited by 3 publications

(2 citation statements)

References 8 publications

(4 reference statements)

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“…This method has especially high diagnostic specificity in pulmonary thromboembolism 8 and chronic obstructive pulmonary disease. 9 The inequality on ventilation-perfusion image, which is caused by impaired pulmonary blood flow and normal ventilation, is an important feature to the understanding of the pathogenesis of such disorders.…”

Section: Discussionmentioning

confidence: 99%

“…8,9 Specifically, it has been part of routine preoperative evaluation for lung cancer resection or bullectomy in patients with chronic obstructive pulmonary disease and for assessment of pulmonary emboli in presence of chronic obstructive disease. 10 Mismatch between ventilation and perfusion is often observed in these disorders as a result of uneven pulmonary blood distribution.…”

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Hypoxia-Induced Pulmonary Blood Redistribution in Subjects With a History of High-Altitude Pulmonary Edema

Hanaoka

Tanaka

et al. 2000

Circulation

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Background-Pulmonary hypertension has been suggested to play an important role in development of high-altitude pulmonary edema (HAPE), and individual susceptibility has been suggested to be associated with enhanced pulmonary vascular response to hypoxia. We hypothesized that much greater pulmonary vasoconstriction would be induced by acute alveolar hypoxia in HAPE-susceptible (HAPE-s) subjects and that changes in pulmonary blood flow distribution could be demonstrated by radionuclide study. Methods and Results-We performed ventilation-perfusion scintigraphy in 8 HAPE-s subjects and 5 control subjects while each was in the supine position and acquired functional images of pulmonary blood flow and ventilation under separate normoxic and hypoxic (arterial oxygen saturation, 70%) conditions. We also measured acceleration time/right ventricular ejection time (AcT/RVET) with Doppler echocardiography under each condition in both groups. Moreover, we assayed human leukocyte antigen (HLA) alleles serologically in the HAPE-s group. Pulmonary blood flow was significantly shifted from the basal lung region to the apical lung region under hypoxia in HAPE-s subjects, although no significant change in regional ventilation was observed. With Doppler echocardiography, HAPE-s subjects showed increased pulmonary arterial pressure during hypoxia compared with control subjects. The magnitude of cephalad redistribution of lung blood flow was significantly higher in the HLA-DR6 -positive than in HLA-DR6 -negative HAPE-s subjects. Conclusions-These findings suggest that acute hypoxia induces much greater cephalad redistribution of pulmonary blood flow that results from exaggerated vasoconstriction in the basal lung in HAPE-s subjects. Furthermore, pulmonary vascular hyperreactivity to hypoxia may be associated with HLA-DR6.

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Section: Discussionmentioning

confidence: 99%

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confidence: 99%

Hypoxia-Induced Pulmonary Blood Redistribution in Subjects With a History of High-Altitude Pulmonary Edema

Hanaoka

Tanaka

et al. 2000

Circulation

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Improving the diagnostic performance of lung scintigraphy in suspected pulmonary embolic disease

2006

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Comparison of lung perfusion scintigraphic findings in pulmonary thromboembolism in systemic lupus erythematosus, SLE plus antiphospholipid syndrome, and primary antiphospholipid syndrome

Aung

Murata²,

Ishida³

et al. 2000

Nuclear Medicine Communications

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In this study, we compared and reviewed the findings on lung perfusion scans performed in patients with systemic lupus erythematosus (SLE), systemic lupus erythematosus with associated antiphospholipid syndrome (SLE + APS), and primary antiphospholipid syndrome (PAPS), to evaluate the prevalence of pulmonary embolism in restricted samples of the patient groups. Lung perfusion scintigraphy with 99Tc(m)-macroaggregated albumin was performed in 31 patients (SLE = 7; SLE + APS = 14; PAPS = 10). The seven patients with SLE alone and the 10 patients with PAPS had normal perfusion lung scans. Six of the 14 SLE + APS patients showed a segmental uptake defect on multi-view perfusion scans. Thus, the SLE + APS patients were found to have a higher risk of pulmonary thromboembolism than the SLE alone and primary APS patients (P<0.05). The results of our study suggest that lung perfusion scintigraphy should be performed routinely in these patients, even in the absence of pulmonary clinical manifestations, to obtain baseline data for disease outcome and management.

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Combined Ventilation-Perfusion Scintigraphy for Demonstration of Pulmonary Embolism

Cited by 3 publications

References 8 publications

Hypoxia-Induced Pulmonary Blood Redistribution in Subjects With a History of High-Altitude Pulmonary Edema

Hypoxia-Induced Pulmonary Blood Redistribution in Subjects With a History of High-Altitude Pulmonary Edema

Improving the diagnostic performance of lung scintigraphy in suspected pulmonary embolic disease

Comparison of lung perfusion scintigraphic findings in pulmonary thromboembolism in systemic lupus erythematosus, SLE plus antiphospholipid syndrome, and primary antiphospholipid syndrome

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