Combined Value of Red Blood Cell Distribution Width and Global Registry of Acute Coronary Events Risk Score for Predicting Cardiovascular Events in Patients with Acute Coronary Syndrome Undergoing Percutaneous Coronary Intervention

Abstract

Global Registry of Acute Coronary Events (GRACE) risk score and red blood cell distribution width (RDW) content can both independently predict major adverse cardiac events (MACEs) in patients with acute coronary syndrome (ACS). We investigated the combined predictive value of RDW and GRACE risk score for cardiovascular events in patients with ACS undergoing percutaneous coronary intervention (PCI) for the first time. We enrolled 480 ACS patients. During a median follow-up time of 37.2 months, 70 (14.58%) patients experienced MACEs. Patients were divided into tertiles according to the baseline RDW content (11.30–12.90, 13.00–13.50, 13.60–16.40). GRACE score was positively correlated with RDW content. Multivariate Cox analysis showed that both GRACE score and RDW content were independent predictors of MACEs (hazard ratio 1.039; 95% confidence interval [CI] 1.024–1.055; p < 0.001; 1.699; 1.294–2.232; p < 0.001; respectively). Furthermore, Kaplan–Meier analysis demonstrated that the risk of MACEs increased with increasing RDW content (p < 0.001). For GRACE score alone, the area under the receiver operating characteristic (ROC) curve for MACEs was 0.749 (95% CI: 0.707–0.787). The area under the ROC curve for MACEs increased to 0.805 (0.766–0.839, p = 0.034) after adding RDW content. The incremental predictive value of combining RDW content and GRACE risk score was significantly improved, also shown by the net reclassification improvement (NRI = 0.352, p < 0.001) and integrated discrimination improvement (IDI = 0.023, p = 0.002). Combining the predictive value of RDW and GRACE risk score yielded a more accurate predictive value for long-term cardiovascular events in ACS patients who underwent PCI as compared to each measure alone.

Preoperative red cell distribution width: Not a useful prognostic indicator for 30-day mortality in patients who undergo major- or ultra-major noncardiac surgery

“…combined the predictive value of RDW and GRACE risk score to yield a more accurate predictive value for long-term cardiovascular events in acute coronary syndrome patients who underwent percutaneous coronary intervention as compared to each measure alone. [36] Recently, Yin et al . reported that a combination of RDW and the ASA score may provide a more powerful and effective strategy (AUC increased from 0.700 to 0.723) for the prediction of all-cause mortality in hip fracture patients.…”

Free triiodothyronine and global registry of acute coronary events risk score on predicting long-term major adverse cardiac events in STEMI patients undergoing primary PCI

“…Global Registry of Acute Coronary Events (GRACE) score was designed to predict the 6-month follow-up morbidity and mortality in patients with acute coronary syndrome [ 13 ]. Later, the ability of GRACE score in risk stratification was demonstrated to have a good predictive value up to 5 years’ follow-up [ 14 ]. Detection of a higher GRACE score was correlated with a poorer prognosis.…”

G-T haplotype established by rs3785889-rs16941382 in GOSR2 gene is associated with coronary artery disease in Chinese Han population

“…Venous blood samples were collected from all participants in fasting state, and genomic DNA was extracted from the peripheral blood leukocytes using phenol and chloroform extraction method in Central Laboratory of People's Hospital of Shaanxi Province from January in 2015 to December in 2016 and stored in -80°C refrigerator for further genotyping [ 22 , 23 ].…”