Combined use of systemic quercetin, glutamine and alpha-tocopherol attenuates myocardial fibrosis in diabetic rats

Purificação, Natan Reyges Castro da; Garcia, Vinícius Barreto; Frez, Flávia Cristina Vieira; Sehaber, Camila Caviquioli; Lima, Kaio Ramon De Aguiar; Lima, Marília Fabiana de Oliveira; Vasconcelos, Roseane de Carvalho; Araújo, Aurigena Antunes de; Júnior, Raimundo Fernandes de Araújo; Lacchini, Sílvia; Oliveira, Flávia de; Perles, Juliana Vanessa Colombo Martins; Zanoni, Jacqueline Nelisis; Lopes, Maria Luiza Diniz de Sousa; Clebis, Naianne Kelly

doi:10.1016/j.biopha.2022.113131

Biomedicine & Pharmacotherapy

2022

DOI: 10.1016/j.biopha.2022.113131

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Combined use of systemic quercetin, glutamine and alpha-tocopherol attenuates myocardial fibrosis in diabetic rats

Natan Reyges Castro da Purificação

Vinícius Barreto Garcia

Flávia Cristina Vieira Frez

et al.

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Cited by 3 publications

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“…Over the past two decades, despite the remarkable advances in the treatment of CVDs, such as coronary artery disease and acute myocardial infarction, the mortality rate remains on the rise [24]. Nowadays, many studies have proposed novel pharmaceuticals and/or dietary antioxidants as a solution with minimal adverse effects for the treatment of various acute and chronic disorders such as cancer [25,26], infertility [27-29], diabetes [30], endometriosis [31], viral infections [32], and CVDs [33,34]. Apigenin is one of the dietary flavonoids that, in addition to its favorite properties (such as anti-inflammatory, antioxidant, anti-tumor, and anti-apoptotic effects), represents the ability to prevent/alleviate CVDs by regulating the expression of miRNAs.…”

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confidence: 99%

The Functionality of Apigenin as a Novel Cardioprotective Nutraceutical with Emphasize on Regulating Cardiac Micro RNAs

Raberi

Esmati

Bodagh

et al. 2022

GMJ

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Cardiovascular diseases (CVDs) are considered the most common disorder and the leading cause of mortality globally. The etiology of CVDs depends on a variety of genetic and acquired parameters. Nowadays, a dramatic surge appeared in published reports to find the association between microRNAs (miRNAs) and CVDs in order to understand the cause of the disease, rapid diagnosis with the introduction of valid biomarkers, and target as a therapeutic approach. Apigenin is a novel nutraceutical flavonoid that cardioprotective properties are suggested. The current review aimed to evaluate the beneficial features of this phytochemical against CVDs with an emphasis on its ability to regulate the miRNAs. The findings demonstrated that Apigenin could regulate cardiac miRNAs, including miR-103, miR-122-5p, miR-15b, miR-155, and miR-33. Consequently, preventing CVDs is possible through different effects such as the promotion of cholesterol efflux, prevention of hyperlipidemia, alteration in ATP Binding Cassette Subfamily A Member 1 (ABCA1) levels, reducing of cardiocytes apoptosis, and retarding myocytes fibrosis. Also, it can regulate signaling pathways, protect against endothelial dysfunction, maintain oxidative balance, and decrease inflammatory factors and reactive oxygen species. Hence, apigenin regulatory characteristics affecting miRNAs expression could introduce this flavonoid as a novel cardioprotective phytochemical against different CVDs.

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mentioning

confidence: 99%

The Functionality of Apigenin as a Novel Cardioprotective Nutraceutical with Emphasize on Regulating Cardiac Micro RNAs

Raberi

Esmati

Bodagh

et al. 2022

GMJ

View full text Add to dashboard Cite

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Flavonoids: Potential therapeutic agents for cardiovascular disease

Liu,

Luo,

Peng

et al. 2024

Heliyon

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Flavonoids quercetin, dihydroquercetin (taxifolin): antioxidant and anti-ischemic effects, possibility of application in cardiology

Dedov,

Usoltseva

2023

Vrach

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Objective. Determination of the place of flavonoids quercetin and dihydroquercetin as a preventive and auxiliary agent in the treatment of cardiovascular diseases. Material and methods. The analysis of literature data was carried out, in which the results of studies on the use of flavonoids quercetin, dihydroquercetin (taxifolin) in animal experiments and in patients with cardiovascular diseases were presented, as well as data from experimental laboratory studies were analyzed. Results and discussion. Flavonoids had antioxidant, antiradical, vasoprotective, antiplatelet, anti-inflammatory effects. They slow down the development of atherosclerosis and cardiovascular diseases, and are also a means of preventing fatal cardiovascular complications. The antihypertensive, anti-ischemic, antiarrhythmic, hypolipidemic, antiplatelet effect of quercetin and dihydroquercetin has been shown. The possibility of using dihydroquercetin in the complex treatment of patients with arterial hypertension is shown. The high efficiency of the drug Bio Dihydroquercetin, which is distinguished by a special author's production technology, and is a highly active dihydroquercetin, of natural origin with proven efficacy and safety, was noted. Taking dihydroquercetin is associated with a decrease in blood viscosity, a decrease in aggregation, an improvement in the deformability of red blood cells, as well as an improvement in endothelial function and tissue perfusion. Conclusions. Flavonoids quercetin, dihydroquercetin (Dihydroquercetin) have antioxidant, vasodilator, hypotensive, antiplatelet, hypolipidemic, anti-ischemic, anti-inflammatory effects. They can be used in the comprehensive prevention and treatment of patients with cardiovascular diseases

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Combined use of systemic quercetin, glutamine and alpha-tocopherol attenuates myocardial fibrosis in diabetic rats

Cited by 3 publications

References 57 publications

The Functionality of Apigenin as a Novel Cardioprotective Nutraceutical with Emphasize on Regulating Cardiac Micro RNAs

The Functionality of Apigenin as a Novel Cardioprotective Nutraceutical with Emphasize on Regulating Cardiac Micro RNAs

Flavonoids: Potential therapeutic agents for cardiovascular disease

Flavonoids quercetin, dihydroquercetin (taxifolin): antioxidant and anti-ischemic effects, possibility of application in cardiology

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