Combined use of rheology and portable low-field NMR in cystic fibrosis patients

Abrami, Michela; Maschio, Massimo; Conese, Massimo; Confalonieri, Marco; Gerin, Fabio; Dapas, Barbara; Farra, Rossella; Adrover, Alessandra; Torelli, Lucio; Ruaro, Barbara; Grassi, Gabriele; Grassi, Mario

doi:10.1016/j.rmed.2021.106623

Cited by 7 publications

(6 citation statements)

References 45 publications

(74 reference statements)

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“…Therefore, the observed degree of correlation between QDP and FEV1%predicted in this study for CF is as expected. Similar correlation coefficients were found in CF between FEV1%predicted and inflammatory markers in sputum assessed by MRI ( 46 , 47 ). For COPD, the lack of relevant correlations in this study is most likely due to a limited range of disease severity in the evaluated COPD patients.…”

Section: Discussionsupporting

confidence: 76%

Unsupervised clustering algorithms improve the reproducibility of dynamic contrast-enhanced magnetic resonance imaging pulmonary perfusion quantification in muco-obstructive lung diseases

et al. 2022

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BackgroundDynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) allows the assessment of pulmonary perfusion, which may play a key role in the development of muco-obstructive lung disease. One problem with quantifying pulmonary perfusion is the high variability of metrics. Quantifying the extent of abnormalities using unsupervised clustering algorithms in residue function maps leads to intrinsic normalization and could reduce variability.PurposeWe investigated the reproducibility of perfusion defects in percent (QDP) in clinically stable patients with cystic fibrosis (CF) and chronic obstructive pulmonary disease (COPD).Methods15 CF (29.3 ± 9.3y, FEV1%predicted = 66.6 ± 15.8%) and 20 COPD (66.5 ± 8.9y, FEV1%predicted = 42.0 ± 13.3%) patients underwent DCE-MRI twice 1 month apart. QDP, pulmonary blood flow (PBF), and pulmonary blood volume (PBV) were computed from residue function maps using an in-house quantification pipeline. A previously validated MRI perfusion score was visually assessed by an expert reader.ResultsOverall, mean QDP, PBF, and PBV did not change within 1 month, except for QDP in COPD (p < 0.05). We observed smaller limits of agreement (± 1.96 SD) related to the median for QDP (CF: ± 38%, COPD: ± 37%) compared to PBF (CF: ± 89%, COPD: ± 55%) and PBV (CF: ± 55%, COPD: ± 51%). QDP correlated moderately with the MRI perfusion score in CF (r = 0.46, p < 0.05) and COPD (r = 0.66, p < 0.001). PBF and PBV correlated poorly with the MRI perfusion score in CF (r =−0.29, p = 0.132 and r =−0.35, p = 0.067, respectively) and moderately in COPD (r =−0.57 and r =−0.57, p < 0.001, respectively).ConclusionIn patients with muco-obstructive lung diseases, QDP was more robust and showed a higher correlation with the MRI perfusion score compared to the traditionally used perfusion metrics PBF and PBV.

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Section: Discussionsupporting

confidence: 76%

Unsupervised clustering algorithms improve the reproducibility of dynamic contrast-enhanced magnetic resonance imaging pulmonary perfusion quantification in muco-obstructive lung diseases

et al. 2022

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“…Morbidity and mortality depend mainly on chronic respiratory failure and malnutrition. Beside usual clinical and spirometrics parameters and sweat chloride concentrations, emergent tools including biomarkers measured in blood, sputum or bronchoalveolar lavage ( 1 ), rheologic tests and low field nuclear magnetic resonance ( 2 ) may help to evaluate disease prognosis and efficacy of new pharmological treatments in the future.…”

Section: Introductionmentioning

confidence: 99%

Prevalence and Impact of Rheumatologic Pain in Cystic Fibrosis Adult Patients

et al. 2022

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BackgroundWith the improvement of cystic fibrosis (CF) patient survival, the prevalence of long-term complications increased, among them rheumatologic disorders.MethodsThe aim of this prospective study was to evaluate the prevalence of spinal and joint pain, and their impact on disability, anxiety, depression, and quality of life in CF adult patients.ResultsForty-seven patients were analyzed, 72% of men, mean aged 28 years, with a mean body mass index of 22 kg/m2 and a mean FEV1% of 63%. Twenty-two patients (47%) described rheumatologic pain either spinal (n = 15, 32%) and/or joint pain (n = 14, 30%). Patients with spinal and/or joint pain were shorter (p = 0.023), more frequently colonized with Staphylococcus aureus (p < 0.008), had more frequent ΔF508 homozygous mutations (p = 0.014), and a trend for more impairment of the 6-min walking distance (p = 0.050). The presence of rheumatologic pain tended to be associated with disability according to the Health Assessment Questionnaire (HAQ) and anxiety. Compared with patients with no pain patients with both spinal and joint pain exhibited a more pronounced impact on the St George's Respiratory Questionnaire (SGRQ).ConclusionRheumatologic pain is frequent in CF adult patients, and may affect daily living, anxiety and quality of life. Systematic assessment of rheumatologic pain should be included in the management of CF patients.

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“…Hence, we found a correlation between T2 and the amount of such elements in the sputum of CF patients [158]; moreover, we observed an inverse correlation with the systemic inflammatory marker CRP and the local inflammatory markers, such as IL-1β and TNF-α [156]. In subsequent work [152], we studied CF sputum characteristics through the combined use of LF-NMR and rheology. In particular, we investigated the correlation of T2 with (1) sputum viscoelasticity, (2) the mucociliary clearability index (MCI)/cough clearability index (CCI), and (3) the sputum average mesh size [154].…”

Section: Mucus In Cfmentioning

confidence: 74%

“…When mucin production is increased, mucus becomes hyperconcentrated, much thicker, and more difficult to clear, thereby affecting mucociliary clearance. These events are shared by nearly all obstructive pulmonary diseases, i.e., CF, COPD [152], and asthma [153]. The respiratory tract consists of two types of cells: ciliated and secretory cells.…”

Section: Mucus Structure In Crdsmentioning

confidence: 99%

Mucus Structure, Viscoelastic Properties, and Composition in Chronic Respiratory Diseases

Abrami,

Biasin,

Tescione

et al. 2024

IJMS

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The respiratory mucus, a viscoelastic gel, effectuates a primary line of the airway defense when operated by the mucociliary clearance. In chronic respiratory diseases (CRDs), such as asthma, chronic obstructive pulmonary disease (COPD), and cystic fibrosis (CF), the mucus is overproduced and its solid content augments, changing its structure and viscoelastic properties and determining a derangement of essential defense mechanisms against opportunistic microbial (virus and bacteria) pathogens. This ensues in damaging of the airways, leading to a vicious cycle of obstruction and infection responsible for the harsh clinical evolution of these CRDs. Here, we review the essential features of normal and pathological mucus (i.e., sputum in CF, COPD, and asthma), i.e., mucin content, structure (mesh size), micro/macro-rheology, pH, and osmotic pressure, ending with the awareness that sputum biomarkers (mucins, inflammatory proteins and peptides, and metabolites) might serve to indicate acute exacerbation and response to therapies. There are some indications that old and novel treatments may change the structure, viscoelastic properties, and biomarker content of sputum; however, a wealth of work is still needed to embrace these measures as correlates of disease severity in association with (or even as substitutes of) pulmonary functional tests.

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Combined use of rheology and portable low-field NMR in cystic fibrosis patients

Cited by 7 publications

References 45 publications

Unsupervised clustering algorithms improve the reproducibility of dynamic contrast-enhanced magnetic resonance imaging pulmonary perfusion quantification in muco-obstructive lung diseases

Unsupervised clustering algorithms improve the reproducibility of dynamic contrast-enhanced magnetic resonance imaging pulmonary perfusion quantification in muco-obstructive lung diseases

Prevalence and Impact of Rheumatologic Pain in Cystic Fibrosis Adult Patients

Mucus Structure, Viscoelastic Properties, and Composition in Chronic Respiratory Diseases

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