Combined use of perfluorohexyloctane and silicone oil as intraocular tamponade: an in vitro study

Abstract

F6H8 dissolves slowly in SIL and equilibrium is only reached after 1 month. The final ratio of the DF phases differs from the initial ratio. An initial F6H8/SIL ratio of 70%:30% vol results in 25% vol of pure F6H8 (density, 1.33 g/cm(3)) and 75% vol of a solution containing F6H8, viz. 60% vol F6H8 in SIL (density 1.17 g/cm(3)). Because of its density and contact properties, the investigated DF has a tamponade effectiveness better than that of SIL on the inferior retina. Compared with using F6H8 alone, DF reduces emulsification.

The concept of heavy tamponades—chances and limitations

“…Double filling with F6H8 and silicone oil demonstrated comparable results [12,33,34]. Interestingly, the combined use of F6H8 and silicone oil demonstrated a reduced emulsification rate in vitro [23]. This supports again the concept that compartmentalisation is of major importance in determining postoperative cell proliferation.…”

Densiron® 68 as an intraocular tamponade for complex inferior retinal detachments

“…Perfluorohexyloctane (F6H8) has also been utilized within model systems due to its higher density; however, the tendency is for this compound to disperse into droplets and emulsify 2. The formation of Densiron ® 68 (Fluoron Gmbh, Neu-Ulm, Germany) is a combination of the higher-density F6H8 and polydimethylsiloxane and has been developed for the purpose of intraocular tamponade for such cases (density 1.06 g/cm 3 ; viscosity 1400 mPas at 25°C).…”

Indikation zum Einsatz verschiedener Endotamponaden

“…Es zeigten sich eine bessere Lçslichkeit bei hçheren Silikonçlanteilen, wobei die Dispersionstendenz im Vergleich zu reinem F 6 H8 reduziert war, ebenso war der retinale Kontakt bei hçheren Silikonçlanteilen vor allem inferior vermindert [10]). ¾hnliche Ergebnisse zeigten Untersuchungen von Lepori et al [25]. Wetterqvist und Kollegen untersuchten 2004 [59] Silikonçl-F6 H8-Mischungen unterschiedlicher Dichte (1,01 bis 1,06 g/cm 3 ) am Modell einer Augenkammer.…”