Combined use of nuclear phosphoprotein c-Myc and cellular phosphoprotein p53 for hepatocellular carcinoma detection in high-risk chronic hepatitis C patients

Abstract

c-Myc and p53 are potential HCC diagnostic biomarkers, and convenient combinations of them could improve diagnostic accuracy of HCC.

Comprehensive investigation of p53, p21, nm23, and VEGF expression in hepatitis B virus-related hepatocellular carcinoma overall survival after hepatectomy

“…As shown in previous studies [4,7,41,42], although four indicators had an effect on the prognosis of patients with hepatocellular carcinoma after surgery, joint analysis was less. This research attempted to study the relationship between the combination of four immunohistochemical indicators and the prognosis.…”

“…Most (70% to 90%) liver cancers occurring worldwide are hepatocellular carcinoma (HCC) [3]. There are many factors contributing to the development of HCC, including alcohol abuse, Aflatoxin-1 and hepatitis B virus (HBV), nonalcoholic fatty liver disease (NAFLD) and hepatitis C virus (HCV) infection [4,5]. In Guangxi, the male and female liver cancer mortality was 69.0/100,000 and 17.9/100,000 respectively, which was the highest fatality rate for male and female patients in China [6].…”

Six autoantibodies as potential serum biomarkers of hepatocellular carcinoma: A prospective multicenter study

“…s‐p53‐Ab has been found as a useful marker of various solid tumors. Both serum c‐myc‐Ab and s‐p53‐Ab are potential diagnostic biomarkers for HCC and the combination usage of both autoantibodies might improve their sensitivity 22,23 …”

British Journal of Biomedical Science in 2019. What have we learned?

“…We start with the liver, not merely because it is the most-researched organ in 2019, or that it has been regularly published upon by the Journal, but as it is of interest to clinical chemists, virologists and cell pathologists [2][3][4]. Hepatitis viruses B and C (HCB, HCV) are major causes of cirrhosis, fibrosis and hepatocellular cancer (HCC).…”

“…Whilst traditional cell pathology/histopathology techniques still have their place, molecular genetics continues to provide insights into the pathophysiology of many cancers. We have already noted several instances where genetic analysis in liver cancer is fruitful [2,[5][6][7][8][9], one looking at XRCC1 [6]. Abbas et al focussed on a different SNP in this gene, finding it (but not SNPs in XRCC2 or XRCC3) to be linked with cervical cancer [35], emphasizing the importance of errors in DNA repair systems in malignancy.…”