Combined use of intraoperative ultrasound and indocyanine green fluorescence imaging to detect liver metastases from colorectal cancer

Abstract

This experience suggests that PDE + ICG, combined with IOUS, may represent a safe and effective tool for ensuring the complete surgical eradication of liver metastases from colorectal cancer.

Effect of liver regeneration on malignant hepatic tumors

“…Ultrasound has the advantage that it can also be used intraoperatively to increase the probability of achieving a negative margin (R0) during resection. Some studies have advocated the use of indocyanine green fluorescence imaging and demonstrate that this furthers increases diagnostic accuracy [99] . A relapse of malignant disease in the liver is a bad prognostic sign for the patient, and the therapeutic options might, depending on anatomical location, liver function and general performance status is limited.…”

Development of thermosensitive chitosan/glicerophospate injectablein situgelling solutions for potential application in intraoperative fluorescence imaging and local therapy of hepatocellular carcinoma: a preliminary study

“…As reported in the literature [11,12,16], fluorescent nodules can be examined by an NIR camera system named PDE (photo dynamic eye, Hamamatsu Photonics K.K. Hamamatsu, Japan), that activates ICG with emitted light at a wavelength of 760 nm and filters out light with a wavelength < 820 nm [17].…”

Usefulness of intraoperative diagnosis of hepatic tumors located at the liver surface and hepatic segmental visualization using indocyanine green-photodynamic eye imaging

“…In 117 patients, we thrombosis, the clinical usefulness of ICG-PDE has already been reported. [17][18][19][20][21][22] In patients with severe liver injury such as cirrhosis or those who underwent ICG administration within a few days, multiple false-positive fluorescent spots were observed. Anatomical resection of the liver can be needed under various circumstances, as described above.…”