Combined use of hyperthermia and radiation therapy for treating locally advanced cervical carcinoma

Lutgens, Ludy; Zee, Jacoba van der; Pijls‐Johannesma, Madelon; Haas-Kock, Danielle F. M. de; Buijsen, Jeroen; Mastrigt, Ghislaine A. P. G. van; Lammering, Guido; Ruysscher, Dirk K.M. De; Lambin, Philippe

doi:10.1002/14651858.cd006377.pub2

Cited by 49 publications

(36 citation statements)

References 41 publications

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“…In 2010, Lutgens et al [7] published a systematic review comparing the combined use of HT and RT with RT alone for treating locally advanced CC. They reported that RT combined with HT yielded superior local tumour control rates (RR, 0.56; 95% CI, 0.39-0.79; p < .001) and OS (HR, 0.67; 95% CI, 0.45-0.99; p ¼ .05) compared with those yielded by RT alone.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

A multicentre randomised clinical trial of chemoradiotherapy plus hyperthermia versus chemoradiotherapy alone in patients with locally advanced cervical cancer

Hirabayashi

Ohguri

Imada³

et al. 2016

International Journal of Hyperthermia

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Section: Discussionmentioning

confidence: 99%

“…Hyperthermia (HT) has also been shown to be effective in the treatment of CC [7]. Two randomised phase III trials comparing patient groups receiving radiotherapy (RT) or RT þ HT as a primary treatment for locally advanced CC showed higher complete response (CR) rates and better overall survival (OS) in the combination therapy group [8,9].…”

Section: Introductionmentioning

confidence: 99%

A multicentre randomised clinical trial of chemoradiotherapy plus hyperthermia versus chemoradiotherapy alone in patients with locally advanced cervical cancer

Hirabayashi

Ohguri

Imada³

et al. 2016

International Journal of Hyperthermia

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“…Thus, hyperthermia influences several molecular parameters involved in sensitizing tumor cells to radiation and can enhance the potential of targeted radiotherapy. Therefore, radiotherapy combined with hyperthermia may become a tool for local control of an inoperable tumor or an adjuvant therapy in the context of surgery [12,13].…”

Section: Discussionmentioning

confidence: 99%

“…Hyperthermia is a type of cancer treatment in which the body tissue is exposed to high temperatures to damage and kill cancer cells; it enhances the effect of radiotherapy and then allows radiation therapy to be performed at lower doses, reducing its side effects without reducing its effectiveness [12,13]. Radiation therapy combined with hyperthermia may become an important tool for the local therapy of unresectable osteosarcomas or an adjuvant treatment in the context of surgical resection.…”

Section: Discussionmentioning

confidence: 99%

Hyperthermia in the Treatment of Post-Actinic Osteosarcomas: Our Anecdotal Experience

Tancredi

Ciuffreda

Cuttitta

et al. 2011

EAJM

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Irradiation-induced sarcomas are a late sequelae of irradiation therapy. Most sarcomas have been reported to occur after exposure to a radiation dose of 55 Gys and above, with a dose ranging from 16 Gys to 112 Gys. These tumours are very aggressive and an early detection is needed for a timely intervention. Surgery is only effective treatment for local control instead chemotherapy is a valuable tool for systemic control of disease. Irradiation therapy use is controversial because of its side effects on a site previously irradiated. Irradiation therapy combined with hyperthermia is a new treatment that overcomes these problems without limiting the effect of radiation therapy. It may become a tool for local control of the unresectable tumours or an adjuvant treatment of the surgery. In this report we present a rare case of irradiation-induced recurrent osteosarcoma involving the chest wall that was treated with surgical resection followed by radiation therapy combined with hyperthermia as an adjuvant treatment of the surgery.Key Words: Hyperthermia, Radiation, Sarcoma ÖzetIşınlama-kaynaklı sarkomlar radyoterapinin geç bir sekelidir. Çoğu sarkomun, 16 Gy ile 112 Gy arasında değişen bir dozu ile, 55 Gy ve üstünde bir radyasyon dozuna maruz kaldıktan sonra oluştuğu bildirilmiştir. Bu tümörler son derece agresiftir ve erken teşhis, zamanında müdahale için gerekli olmaktadır. Cerrahi, kemoterapiden farklı olarak sadece yerel kontrolü için etkili bir tedavi değildir aynı zamanda sistemik hastalığın kontrolü için değerli bir araçtır. Işınlama tedavisi kullanımı önceden ışınlanmış bir bölgenin tekrar ışınlanmasındaki yan etkileri nedeniyle tartışmalı bir konudur. Hipertermi ile kombine ışınlama, radyasyon tedavisinin sınırlanması olmadan bu sorunların üstesinden gelindiği yeni bir tedavi yöntemidir. Rezeke edilemeyen tümörlerin lokal kontrolü veya cerrahi bir adjuvan tedavi için bir araç haline gelebilir. Bu yazıda, cerrahi rezeksiyonu takip eden radyasyon tedavisi ile göğüs duvarının tekrarlayan bir osteosarkomunun cerrahinin adjuvan tedavisi olarak bir hipertermi ve ışınlama ile birlikte yapılan radyoterapiyi takiben cerrahi rezeksiyonla tedavi edilen nadir bir olgu sunuyoruz.

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“…The standard treatment for locally advanced cervical cancer is external beam radiotherapy with image-guided adaptive brachytherapy [1,2] and concurrent chemotherapy [3,4] or hyperthermia [5]. More than 90% of patients show complete local response after such treatment [6][7][8].…”

Section: Introductionmentioning

confidence: 99%

Evaluation of T2-W MR imaging and diffusion-weighted imaging for the early post-treatment local response assessment of patients treated conservatively for cervical cancer: a multicentre study

et al. 2018

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Objectives To compare MR imaging with or without DWI and clinical response evaluation (CRE) in the local control evaluation of cervical carcinoma after radiotherapy. Methods In a multicentre university setting, we prospectively included 107 patients with primary cervical cancer treated with radiotherapy. Sensitivity and specificity for CRE and MR imaging (with pre-therapy MR imaging as reference) (2 readers) were evaluated using cautious and strict criteria for identifying residual tumour. Nested logistic regression models were constructed for CRE, subsequently adding MR imaging with and without DWI as independent variables, as well as the pre-to post-treatment change in apparent diffusion coefficient (delta ADC). Results Using cautious criteria, CRE and MR imaging with DWI (reader 1/reader 2) have comparable high specificity (83% and 89%/ 95%, respectively), whereas MR imaging without DWI showed significantly lower specificity (63%/53%) than CRE. Using strict criteria, CRE and MR imaging with DWI both showed very high specificity (99% and 92%/95%, respectively), whereas MR imaging without DWI showed significantly lower specificity (89%/77%) than CRE. All sensitivities were not significantly different. Addition of MR imaging with DWI to CRE has statistically significant incremental value in identifying residual tumour (reader 1: estimate, 1.06; p = 0.001) (reader 2: estimate, 0.62; p = 0.02). Adding the delta ADC did not have significant incremental value in detecting residual tumour. Conclusions DWI significantly increases the specificity of MR imaging in the detection of local residual tumour. Furthermore, MR imaging with DWI has significant incremental diagnostic value over CRE, whereas adding the delta ADC has no incremental diagnostic value. Key Points • If MR imaging is used for response evaluation, DWI should be incorporated • MR imaging with DWI has diagnostic value comparable/complementary to clinical response evaluation • Inter-reader agreement is moderate to fair for two experienced radiologist readers • Quantitative measurements of ADC early post-therapy have limited diagnostic value

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Combined use of hyperthermia and radiation therapy for treating locally advanced cervical carcinoma

Cited by 49 publications

References 41 publications

A multicentre randomised clinical trial of chemoradiotherapy plus hyperthermia versus chemoradiotherapy alone in patients with locally advanced cervical cancer

A multicentre randomised clinical trial of chemoradiotherapy plus hyperthermia versus chemoradiotherapy alone in patients with locally advanced cervical cancer

Hyperthermia in the Treatment of Post-Actinic Osteosarcomas: Our Anecdotal Experience

Evaluation of T2-W MR imaging and diffusion-weighted imaging for the early post-treatment local response assessment of patients treated conservatively for cervical cancer: a multicentre study

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