Combined use of biochemical and volumetric biomarkers to assess the risk of conversion of mild cognitive impairment to Alzheimer’s disease

Nesteruk, Marta; Nesteruk, Tomasz; Styczyńska, Maria; Mandecka, Monika; Barczak, Anna; Barcikowska, Maria

doi:10.5114/fn.2016.64815

Cited by 17 publications

(13 citation statements)

References 12 publications

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“…In 2018, the National Institute on Aging and the Alzheimer's Association presented the research framework [44] that similarly as the Erlangen Score Algorithm [19,28] did not officially include apoE as AD biomarker, probably due to contradicting results regarding its function in animal models [4,24] and diverse data on apoE level in human AD pathology [27]. There are studies performed on peripheral blood drawn from AD patients, demonstrating elevated [26,62,66], unchanged [11,32,39,46,53,57,61] and reduced apoE levels [18,20,29,30,36,52,55,60,68] in [72].…”

Section: Discussionmentioning

confidence: 99%

APOE genetic variants and apoE, miR-107 and miR-650 levels in Alzheimer’s disease

Prendecki¹,

Florczak-Wyspiańska²,

Kowalska³

et al. 2019

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Alzheimer's disease (AD) is a progressive neurodegenerative dementia in adults. Pathogenesis of AD depends on various factors, including APOE genetic variants, apolipoprotein E (apoE) phenotype and oxidative stress, which may promote both DNA and RNA damage, including non-coding RNA (ncRNA). Among ncRNAs, microRNA (miRNA) is known to contribute to pathologic processes in AD. The aim of the study was to analyse the plasma concentration of apoE by ELISA as well as the plasma levels of miR-107 and miR-650 by qPCR in relation to APOE genetic variants and clinical features including the age of onset and dementia severity in 64 AD patients and 132 controls. Our data showed that a low apoE plasma concentration was a risk factor for developing AD (OR = 5.18, p = 6.58E-06) and was particularly pronounced in severe dementia (p < 0.001) and correlated with cognitive functions (R = 0.295, p = 0.020), similarly as the level of miR-650 (R = 0.385, p = 0.033). The presence of APOE E4 allele in both AD patients and controls led to a reduction in apoE, while APOE E3/E3 genotype was associated with an increased apoE concentration and level of miR-107 in AD (p < 0.05) which was inversely correlated with the number of APOE E4 alleles (R =-0.448, p = 0.009). Additionally, patients with the onset at 60-69 years of age showed a reduced level of miR-107 (p < 0.05, as compared to AD above 80 years of age). Changed levels of plasma apoE, miR-107 and miR-650 may be a marker of the neurodegenerative process in the course of AD, associated with amyloid β metabolism and inordinate cell cycle.

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Section: Discussionmentioning

confidence: 99%

APOE genetic variants and apoE, miR-107 and miR-650 levels in Alzheimer’s disease

Prendecki¹,

Florczak-Wyspiańska²,

Kowalska³

et al. 2019

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“…Characterized by deficits in attention, executive function, working memory and information processing ( Sampath et al, 2017 ), Mild Cognitive Impairment (MCI) is considered to be a critical stage intermediate period between normal aging and dementia. Data show that 20–30% of patients who were diagnosed as MCI will develop into dementia like Alzheimer’s disease (AD) in 2 years ( Alzheimer’s Association, 2016 ; Nesteruk et al, 2016 ; Pena-Altamira et al, 2017 ). What are the earliest origins of AD?…”

Section: Introductionmentioning

confidence: 99%

The Correlation between Early Stages of Life Exposed to Chinese Famine and Cognitive Decline in Adulthood: Nutrition of Adulthood Plays an Important Role in the Link?

Rong

et al. 2018

Front. Aging Neurosci.

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Objective: The aim of this study was to investigate whether people exposed to the Chinese Famine in fetal period or in multiple stages of childhood are associated with cognitive decline in adulthood. Furthermore, the nutritional environment of adulthood was explored as an important factor in this correlation.Methods: 1162 adults born between 1952 and 1964 were recruited. They were divided into five groups which were non-exposed group, fetal-exposed group, early childhood-exposed group, mid childhood-exposed group and late childhood-exposed group. Cognitive function was measured by using a comprehensive neuropsychological battery test, including Montreal cognitive assessment-Beijing version, mini-mental state examination, auditory verbal learning test, digit span forward, digit span backward, trail making test, and digit symbol test. Semi-quantified food frequency questionnaire (FFQ) was used to assess the dietary nutrition in their adulthood. The dietary nutrient consumption pattern was identified by Two-step and K-means cluster analysis.Results: The significant differences in cognitive function were manifested in different groups. Compared with non-exposed group, subjects in fetal-exposed group had a higher risk of mild cognitive impairment (MCI) (OR 1.51 95% CI 1.02–2.23, P = 0.039) and global cognitive decline (OR 1.68 59% CI 1.02–2.77, P = 0.044). The similar result was also observed in subjects of early childhood-exposed group. Otherwise, subjects who were classified in high nutrient consumption pattern had higher risk of cognitive decline. Moreover, the higher consumption of several nutrients such as fat, carbohydrate and manganese were associated with worse performance on digit span forward, digit span backward, trail making test A, trail making test B and digit symbol.Conclusion: Early stages of life exposed to the Chinese Famine were associated with higher risk of cognitive decline in adulthood. The stronger associations were manifested in the people with high nutrient consumption pattern. The consumption of fat, carbohydrate and manganese were associated with multiple domains cognitive decline.

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“…There are many studies analyzing significant biomarkers associated with MCI-to-AD conversion, but the results have been inconsistent. Some studies have demonstrated that different biomarkers, including hippocampal volume, the CSF tau/Aβ-42 ratio, tau proteins and Aβ levels, which had great sensitivity up to 88.9% and specificity up to 96.8%, and the combined assessment outperformed single biomarker assessments 34,35 . Other studies have also shown that absent APOE4 alleles may predict MCI stability for at least 3 years 36 , plasma homocysteine and serum brain-derived neurotrophic factor may predict MCI-to-AD conversion in patients with the APOE ε4 genotype 37 , and plasma beta-secretase 1 activity is significantly increased in MCI converters 38 .…”

Section: Discussionmentioning

confidence: 99%

Plasma Transthyretin as a Predictor of Amnestic Mild Cognitive Impairment Conversion to Dementia

Tien

Lee

Liao

et al. 2019

Sci Rep

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Amnestic mild cognitive impairment (MCI) is a prodromal stage of dementia, with a higher incidence of these patients progressing to Alzheimer’s disease (AD) than normal aging people. A biomarker for the early detection and prediction for this progression is important. We recruited MCI subjects in three teaching hospitals and conducted longitudinal follow-up for 5 years at one-year intervals. Cognitively healthy controls were recruited for comparisom at baseline. Plasma transthyretin (TTR) levels were measured by ELISA. Survival analysis with time to AD conversion as an outcome variable was calculated with the multivariable Cox proportional hazards models using TTR as a continuous variable with adjustment for other covariates and bootstrapping resampling analysis. In total, 184 MCI subjects and 40 sex- and age-matched controls were recruited at baseline. At baseline, MCI patients had higher TTR levels compared with the control group. During the longitudinal follow-ups, 135 MCI patients (73.4%) completed follow-up at least once. The TTR level was an independent predictor for MCI conversion to AD when using TTR as a continuous variable (p = 0.023, 95% CI 1.001–1.007). In addition, in MCI converters, the TTR level at the point when they converted to AD was significantly lower than that at baseline (328.6 ± 66.5 vs. 381.9 ± 77.6 ug/ml, p < 0.001). Our study demonstrates the temporal relationship between the plasma TTR level and the conversion from MCI to AD.

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Combined use of biochemical and volumetric biomarkers to assess the risk of conversion of mild cognitive impairment to Alzheimer’s disease

Cited by 17 publications

References 12 publications

APOE genetic variants and apoE, miR-107 and miR-650 levels in Alzheimer’s disease

APOE genetic variants and apoE, miR-107 and miR-650 levels in Alzheimer’s disease

The Correlation between Early Stages of Life Exposed to Chinese Famine and Cognitive Decline in Adulthood: Nutrition of Adulthood Plays an Important Role in the Link?

Plasma Transthyretin as a Predictor of Amnestic Mild Cognitive Impairment Conversion to Dementia

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