Combined-type Osteosarcoma in a Rhesus Macaque

Abstract

A femoral mass from a 15-year-old rhesus macaque was evaluated. Grossly, the mass consisted of a large, osteolytic focus in the distal femur, a gelatinous core of neoplastic tissue in the medullary cavity, and an invasive mass-obliterating musculature of the thigh. On histopathologic evaluation, three neoplastic mesenchymal cell populations, osteoblasts, fibroblasts, and primitive mesenchymal cells were identified. The mass was diagnosed as a combined type osteosarcoma. To our knowledge, this is the first osteosarcoma in a rhesus macaque with this subclassification.

Sustained high-level polyclonal hematopoietic marking and transgene expression 4 years after autologous transplantation of rhesus macaques with SIV lentiviral vector–transduced CD34+ cells

“…61 In a much smaller aging study, 164 necropsies were performed on macaques 15 years of age or older that died spontaneously or were euthanized for medical problems. 62 None had been irradiated. In 30%, tumors were discovered, including one oral squamous carcinoma and one osteosarcoma.…”

Neoplasia and Proliferative Disorders of Nonhuman Primates

“…body weight) of most nonhuman primates. The majority of spontaneous bone tumors have been reported in rhesus monkeys and osteosarcomas involving the skull and appendicular skeleton predominate although there are rare cases of osteosarcoma arising in long bones (Chapman and Allen, 1968;Sembrat and Fritz, 1979;Beam, 2005). Also reported in rhesus macaques are single cases of extraosseous osteosarcoma (Gliatto et al, 1990) and an enchondroma (Silverman et al, 1994).…”

The Incidence of Spontaneous Neoplasia in Two Populations of Captive Rhesus Macaques (Macaca mulatta)

“…One animal had a combined-type osteosarcoma of the left femur (2). There were no metastases noted on radiographs and the limb was amputated.…”