2000
DOI: 10.1089/cap.2000.10.307
|View full text |Cite
|
Sign up to set email alerts
|

Combined Treatment with Haloperidol and Trazodone in Patients with Tic Disorders

Abstract: The combination of haloperidol and trazodone was evaluated in an open-label trial in 10 patients with chronic tic and Tourette's syndrome. We found a mean reduction of symptoms of 58.9% on the Yale Global Tic Severity Scale, with a statistically significant difference (p < 0.001) between the baseline and endpoint treatment conditions. This approach significantly reduces clinical symptoms, with the advantage of a lower dose of haloperidol than usual, with no side effects reported by the patients.

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1
1

Citation Types

0
4
0

Year Published

2001
2001
2015
2015

Publication Types

Select...
4
2

Relationship

0
6

Authors

Journals

citations
Cited by 10 publications
(4 citation statements)
references
References 1 publication
0
4
0
Order By: Relevance
“…To date, there are no data on the use of trazodone in children and adolescents with MDD. In a small open-label study of ten children with chronic tic and Tourette’s syndrome, the combination of haloperidol and trazodone was shown to improve clinical symptoms effectively [57]. At study end, the Yale Global Tic Severity Scale score was significantly reduced from baseline, and no adverse effects were reported.…”
Section: Efficacy and Tolerability Of Trazodone In Mddmentioning
confidence: 99%
“…To date, there are no data on the use of trazodone in children and adolescents with MDD. In a small open-label study of ten children with chronic tic and Tourette’s syndrome, the combination of haloperidol and trazodone was shown to improve clinical symptoms effectively [57]. At study end, the Yale Global Tic Severity Scale score was significantly reduced from baseline, and no adverse effects were reported.…”
Section: Efficacy and Tolerability Of Trazodone In Mddmentioning
confidence: 99%
“…TRA is commonly prescribed to pediatric patients - not only for insomnia [59] and mood disorders [60], [61], but also for migraine prophylaxis [62] and treatment of behavior disorders (such as tic disorders [63], aggressive behavior disorders [64], and attention disorders [65]). Thus our current findings raise important questions regarding the consequences of long-term use of these drugs in pediatric populations.…”
Section: Discussionmentioning
confidence: 99%
“…Various drugs have been evaluated for the treatment of patients with Tourette syndrome [5][6][7][8][9][10][11][12][13][14][15][16][31][32][33][34][35][36][37]. Although haloperidol improves symptoms in the majority of patients [5], potential side effects such as tardive dyskinesia are of concern.…”
Section: Discussionmentioning
confidence: 99%
“…Drugs indicated for the treatment of Tourette syndrome include haloperidol and pimozide [5][6][7][8]; however, these drugs are associated with troubling side effects that can lead to discontinuation [9]. Antipsychotic drugs [6,[10][11][12][13][14][15], dopamine antagonists [16], and botulinum toxin type A [17] are being evaluated for the treatment of tics, but no single agent has emerged as an ideal therapy.…”
Section: Introductionmentioning
confidence: 99%