Combined Treatment 3D-conformal Radiotherapy Plus HDR Brachytherapy as Treatment for Intermediate- or High-risk Prostate Cancer: Early Toxicty and Biochemical Outcome of a Dose-escalation Prospective Randomized Trial

Guix, B.; Bartrina, J.; Henrı́quez, I.; Tello, J.; Vendrell, Juan Bosco; Serrate, R

doi:10.1016/j.ijrobp.2007.07.153

Cited by 4 publications

(6 citation statements)

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“…A wide range of HDR and fractionation schedules have been published [33,34,[36][37][38][39][40][41][42][43][44][45][46][47] (Table 3). Typically, 1-4 fractions are usually combined with EBRT at a dose of 36-54 Gy, either with a single implant or with 2 PSA, prostate-specific antigen.…”

Section: Evidence For the Efficacy Of High Dose Rate Brachytherapy Boostmentioning

confidence: 99%

High dose rate prostate brachytherapy: an overview of the rationale, experience and emerging applications in the treatment of prostate cancer

Challapalli

Jones²,

Harvey³

et al. 2012

The British Journal of Radiology

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The technological advances in real-time ultrasound image guidance for high dose rate (HDR) prostate brachytherapy places this treatment modality at the forefront of innovation in radiotherapy. This review article will explore the rationale for HDR brachytherapy as a highly conformal method of dose delivery and safe dose escalation to the prostate, in addition to the particular radiobiological advantages it has over low dose rate and external beam radiotherapy. The encouraging outcome data and favourable toxicity profile will be discussed before looking at emerging applications for the future and how this procedure will feature alongside stereotactic radiosurgery.

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Section: Evidence For the Efficacy Of High Dose Rate Brachytherapy Boostmentioning

confidence: 99%

High dose rate prostate brachytherapy: an overview of the rationale, experience and emerging applications in the treatment of prostate cancer

Challapalli

Jones²,

Harvey³

et al. 2012

The British Journal of Radiology

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“…Besides modern external-beam radiotherapy (EBRT) techniques like 3D conformal radiotherapy or intensity-modulated radiotherapy, brachytherapy (BT) could be a feasible method for achieving local dose escalation with stable or reduced acute and late morbidity [3][4][5].…”

Section: Hdrmentioning

confidence: 99%

Open MR-Guided High-Dose-Rate (HDR) Prostate Brachytherapy: Feasibility and Initial Experiences Open MR-Guided High-Dose-Rate (HDR) Prostate Brachytherapy

Lakosi

Antal

Vandulek

et al. 2011

Pathol. Oncol. Res.

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The aim of our pilot study was to demonstrate the feasibility and dosimetric quality of MR-guided HDR prostate brachytherapy in a low-field 0.35T open MRI scanner and to present our initial clinical experiences. 16 patients with intermediate- to high-risk localized prostate cancer were treated with 46-60 Gy of external beam radiotherapy preceded and/or followed by an 8 Gy MR-guided HDR boost. For interventions an MR compatible custom-made system, coaxial needles and plastic catheters were used. Template reconstruction, trajectory planning, image guidance, contouring and treatment planning were exclusively based on MR images. For treatment planning, dose-point- and anatomy-based inverse planning optimization was used. Image quality was found to be good to excellent in almost all cases. The mean catheter placement accuracy modeled by Rayleigh distribution was 2.9 mm with a sigma value of 2.3 mm. The mean and standard deviation (SD) of the dosimetric results for the target volume were the following: V100: 94.2 ± 4.3%, V150: 43.9 ± 6.8%, V200: 18.5 ± 5.9%. The mean D(0.1), D(1) and D1 values for the intraprostatic urethra were 117.6 ± 12.5%, 98.5 ± 19.9% and 122.3 ± 16.4%, respectively. Regarding the rectal wall the mean D(0.1), D(1) and D(2) values were 77.3 ± 7.2%, 64.8 ± 7.5%, and 53.2 ± 9.1%, respectively. The mean maximum dose for the inner rectal surface was 53.5 ± 9.2%. No RTOG Grade 3 or worse acute toxicities were observed. Our method seems to be a promising approach for performing feasible, accurate and high-quality MR-guided HDR prostate brachytherapy. To determine the long term side effects and outcome higher number of patients, additional follow-up is needed.

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“…The standard external-beam RT dose varies somewhat from one medical institution to another, but in the studies included in the current review, generally 3600 cGy to 5000 cGy was delivered in 20 to 28 daily treatment sessions. 3,[13][14][15][16][17][18][19][20][21][22][23] High-doserate prostate brachytherapy was used in these studies to deliver an additional 1200 cGy to 3000 cGy to the prostate. 3,[13][14][15][16][17][18][19][20][21][22][23] High-dose-rate brachytherapy may be performed before external-beam RT, after its completion, or in the midst of this component of RT.…”

Section: Combined Brachytherapy and External-beam Rtmentioning

confidence: 99%

“…The combination of HDR brachytherapy and externalbeam RT appears to be well tolerated by most patients. Severe gastrointestinal adverse events typically occur in less than 1% of patients, 13,[16][17][18][19]21,22 and moderate gastrointestinal adverse events are experienced by approximately 5% of patients. [16][17][18][19]21,22 Likewise, severe genitourinary adverse events, mainly consisting of urethral stricture responsive to dilatation, are not apt to occur, 13,[16][17][18]21,22,38 a HDR = high-dose-rate; RT = radiotherapy.…”

Section: Combined Brachytherapy and External-beam Rtmentioning

confidence: 99%

“…whereas mild to moderate genitourinary adverse events occur in approximately 10% of patients. [16][17][18]21,22 Duchesne et al 39 noted that adverse events resolve in two-thirds of affected patients after combination therapy, so chronic sequelae are decidedly uncommon. Urinary incontinence was noted in less than 4% of patients, mainly occurring only in the setting of previous or subsequent TURP.…”

Section: Risk Group Bmentioning

confidence: 99%

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High-Dose-Rate Brachytherapy in the Curative Treatment of Patients With Localized Prostate Cancer

Pisansky

Gold

Furutani

et al. 2008

Mayo Clinic Proceedings

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High-dose-rate brachytherapy is a relatively new radiotherapeutic intervention that is used as a curative treatment for patients with many types of cancer. Advances in mechanical systems and computer applications result in a sophisticated treatment technique that reliably delivers a high-quality radiation dose distribution to the intended target. Patients with localized prostate cancer may benefit from high-dose-rate brachytherapy, which may be used alone in certain circumstances or in combination with external-beam radiotherapy in other settings. The authors comprehensively searched the MEDLINE database for clinical studies published from January 1, 2002, through December 31, 2007, using the key terms brachytherapy, high-dose-rate, and prostatic neoplasms. Criteria for study review were study design, English language, relevance to clinicians, and validity based on design and appropriateness of conclusions. The abstract proceedings of meetings sponsored by the American Brachytherapy Society and the American Society for Therapeutic Radiology and Oncology were reviewed to identify additional relevant material. These sources provided the basis for a concise review of the rationale and advantages of high-dose-rate brachytherapy in the management of localized prostate cancer, as well as the details of the clinical use and therapeutic outcomes of this treatment as observed in a contemporaneous time frame.

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Combined Treatment 3D-conformal Radiotherapy Plus HDR Brachytherapy as Treatment for Intermediate- or High-risk Prostate Cancer: Early Toxicty and Biochemical Outcome of a Dose-escalation Prospective Randomized Trial

Cited by 4 publications

References 0 publications

High dose rate prostate brachytherapy: an overview of the rationale, experience and emerging applications in the treatment of prostate cancer

High dose rate prostate brachytherapy: an overview of the rationale, experience and emerging applications in the treatment of prostate cancer

Open MR-Guided High-Dose-Rate (HDR) Prostate Brachytherapy: Feasibility and Initial Experiences Open MR-Guided High-Dose-Rate (HDR) Prostate Brachytherapy

High-Dose-Rate Brachytherapy in the Curative Treatment of Patients With Localized Prostate Cancer

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