Combined transient and peripheral defects in tetrahydrobiopterin synthesis

Allanson, Judith; McInnes, Roderick R.; Bradley, Linda; Tarby, Theodore J.; Naylor, Edwin W.; Nardella, Maria

doi:10.1016/s0022-3476(05)80498-6

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Cited by 6 publications

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“…This may be due to differences in methods and procedures. In other studies, biopterin and biogenic amine metabolites were not simultaneously evaluated (2-6, 8, 13), the control pa-tients had neurological diseases (2,6,8), the patients' conditions were not described in detail (2-5, 8, 13) or there was a relatively small number of patients (2)(3)(4)(5)(6)13).…”

Section: Discussionmentioning

confidence: 99%

Effect of age on cerebrospinal fluid levels of metabolites of biopterin and biogenic amines

Komori¹,

Matsuishi²,

Yamada³

et al. 1999

SPAE

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We identified an age effect on biopterin and biogenic amine metabolites in the cerebrospinal fluid from 56 neurologically normal patients, aged 1 mo to 80 y. The levels of total and reduced forms of biopterin, homovanillic acid, and 5-hydroxyindoleacetic acid were found to peak during the first year of life. The levels of these metabolites then gradually decreased, plateauing at the age of 20 y. We found significant correlations between biopterin, homovanillic acid, and 5-hydroxy-indoleacetic acid.

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