Combined transcranial magnetic stimulation in the treatment of chronic tinnitus

Formánek, Martin; Migaľová, Petra; Krulová, Petra; Bar, Michal; Jančatová, Debora; Zakopčanová-Srovnalová, Hana; Tomášková, Hana; Zeleník, Karol; Komínek, Pavel

doi:10.1002/acn3.587

Cited by 31 publications

(67 citation statements)

References 28 publications

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“…Restrained by the limited number of eligible studies and the nature of the target population, more proposals to encourage large-sample, multi-center, randomized double-blind trials are needed for further veri cation. Left tem cort Formanek M 2018 [5] Czech Republic Folmer RL 2015 [23] The USA [24] Taiwan, China Left prim Noh TS 2019 [25] South Korea 1-Hz-rTMS (2,000 pulses over the AC and 1,000 pulses over the DLPFC, 110% or lower motor threshold )…”

Section: Resultsmentioning

confidence: 99%

“…Fifteen studies [5,15,17,19,20,23,27,[27][28][29][30][31]36,39] reporting adverse events after rTMS sessions were meta-analyzed using a xed-effect model, with nonsigni cant heterogeneity among the studies (I 2 = 37%, P = 0.13). The results showed a nonsigni cant difference in the incidence of adverse events between the rTMS and sham-rTMS groups (12.55% vs. 13.38%, OR: 1.11, 95%CI: 0.51-2.42, P = 0.79) (Fig.7).…”

Section: Adverse Eventsmentioning

confidence: 99%

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Repetitive Transcranial Magnetic Stimulation on Chronic Tinnitus: A Systematic Review and Meta-Analysis

Liang

Gang

Huang

et al. 2020

Preprint

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Background: Although the clinical efficacy and safety of repetitive transcranial magnetic stimulation (rTMS) in the treatment of chronic tinnitus have been frequently examined, the results remain controversial. Therefore, we systematically meta-classified clinical trials concerning the effects of rTMS to evaluate its clinical efficacy and safety. Methods: Studies of rTMS for chronic tinnitus were retrieved in PubMed, Embase, and Cochrane Library due April 2020. Review Manager 5.3 software was employed for data synthesis and Stata 13.0 software for analyses of publication bias and sensitivity. Results: Twenty-nine randomized studies representing 1,228 chronic tinnitus patients were included. Compared with sham-rTMS, rTMS exhibited significant improvements in the tinnitus handicap inventory (THI) score 1-week (mean difference [MD] -7.92, 95% confidence interval [CI] -14.18,-1.66), 1-month (MD -8.52, 95% CI -12.49, -4.55), and 6-month post-intervention (MD -6.53, 95% CI -11.406,-1.66), the mean change in THI scores 1- (MD -14.86, 95% CI -21.42,-8.29) and 6-month post-intervention (MD -16.37, 95% CI -20.64,-12.11), and the tinnitus questionnaire (TQ) score 1-week post-intervention (MD -8.54, 95% CI -15.56,-1.52). Non-significant efficacy of rTMS was found concerning the THI score 2-week post-intervention (MD -1.51, 95% CI -13.42,-10.40), the mean change in TQ scores 1-month post-intervention (MD -3.67, 95% CI -8.56,1.22), the TQ score 1- (MD -8.97, 95% CI -20.41,2.48) and 6-month post-intervention (MD -7.02, 95% CI -18.18,4.13), and adverse events (odds ratios [OR] 1.11, 95% CI 0.51,2.42). The Egger's and Begg's tests indicated no publication bias ( P = 0.925). Conclusion: This meta-analysis demonstrates that rTMS is effective for chronic tinnitus; however, its safety needs more validations. Restrained by the limited number of included studies and the small sample size, more large randomized double-blind multi-center trials are needed for further verification.

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Section: Resultsmentioning

confidence: 99%

Section: Adverse Eventsmentioning

confidence: 99%

Repetitive Transcranial Magnetic Stimulation on Chronic Tinnitus: A Systematic Review and Meta-Analysis

Liang

Gang

Huang

et al. 2020

Preprint

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“…18 In a study conducted by Ho Yun Lee revealed that there was reduction of THI score of ~28.69 points following bifrontal transcranial direct current stimulation. 21 Recently new treatment options have emerged in form of repetitive transcranial magnetic stimulation and deep brain stimulation. However, most of them are still under investigation for their effect.…”

Section: Discussionmentioning

confidence: 99%

“…Formanek et al found that there was no significant effect of repetitive transcranial magnetic stimulation on THI. 21 Past research has demonstrated significant reduction in THI by deep brain stimulation, but being an experimental and invasive procedure, its effectiveness is under debate. 22…”

Section: Discussionmentioning

confidence: 99%

A Prospective Study to Evaluate Effectiveness of a Tinnitus Relief Device in a Clinical Setup

Aggarwal¹,

Gupta²,

Goyal³

2019

AONO

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Introduction Tinnitus has been shown to decrease the quality of life of a person. Being a less understood domain of the medical field, there are no definitive established therapies that can be applied to all patients of tinnitus. The current study is an effort to evaluate the effectiveness of the Tinnitus Relief device in the patients of tinnitus. Aim To evaluate the effectiveness of Tinnitus Relief device TRx in treatment of tinnitus. Methods A prospective study involving 67 participants suffering from tinnitus was conducted in a clinical setup at Delhi, Chandigarh, and Mumbai. These participants were subjected to pure tone audiometry (PTA) and an interview using Tinnitus Handicap Inventory (THI) questionnaire. These participants were advised to use Tinnitus Relief device TR201, TR301, TR401 for more than 6 to 10 months. Improvement in tinnitus in terms of percentage, questions pertaining to THI, and overall improvement in life (subjective) were evaluated after discontinuation of the use of the device in each participant. Results It was found that there was significant improvement in mean THI score, following treatment with Tinnitus Relief TRx. This device was also able to completely alleviate 5 out of 12 associated complaints of tinnitus. No association could be found between the use of Tinnitus Relief therapy and hearing loss. Conclusion Tinnitus Relief TRx can emerge as an effective tool for treatment of the tinnitus and can improve the life of the sufferer.

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“…Extensive means of treating tinnitus have been developed, which include medications ( von Boetticher, 2011 ; Bhatt et al , 2016 ), counselling and cognitive behaviour therapy, transcranial magnetic stimulation ( Kreuzer et al , 2017 ; Formánek et al , 2018 ), transcranial direct current stimulation (tDCS) and transcranial magnetic stimulation (TMS) ( Bae et al , 2020 ), tinnitus retraining therapy ( Scherer et al , 2014 ; Kim et al , 2016 ; Lee et al , 2019 ), relaxation therapy, hearing aids ( Searchfield et al , 2010 ) and sound therapy ( Hall et al , 2015 ; Langguth, 2015 ; Blakley, 2016 ; Plein et al , 2016 ; Makar et al , 2017 ). According to the clinical practice guidelines of tinnitus, sound therapy is one of the recommended treatments ( Tunkel et al , 2014 ) and is used as a standard treatment in the UK ( Baguley et al , 2013 ).…”

Section: Introductionmentioning

confidence: 99%

The effects of sound therapy in tinnitus are characterized by altered limbic and auditory networks

Zhao

Liu

et al. 2020

Brain Communications

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To determine the neural mechanism underlying the effects of sound therapy on tinnitus, we hypothesize that sound therapy may be effective by modulating both local neural activity and functional connectivity that is associated with auditory perception, auditory information storage or emotional processing. In this prospective observational study, thirty tinnitus patients underwent resting-state functional magnetic resonance imaging scans at baseline and after 12 weeks of sound therapy. Thirty-two age- and gender-matched healthy controls also underwent two scans over a 12-week interval; thirty of these healthy controls were enrolled for data analysis. The amplitude of low-frequency fluctuation was analysed, and seed-based functional connectivity measures were shown to significantly alter spontaneous local brain activity and its connections to other brain regions. Interaction effects between the two groups and the two scans in local neural activity as assessed by the amplitude of low-frequency fluctuation were observed in the left parahippocampal gyrus and the right Heschl's gyrus. Importantly, local functional activity in the left parahippocampal gyrus in the patient group was significantly higher than that in the healthy controls at baseline and was reduced to relatively normal levels after treatment. Conversely, activity in the right Heschl's gyrus was significantly increased and extended beyond a relatively normal range after sound therapy. These changes were found to be positively correlated with tinnitus relief. The functional connectivity between the left parahippocampal gyrus and the cingulate cortex was higher in tinnitus patients after treatment. The alterations of local activity and functional connectivity in the left parahippocampal gyrus and right Heschl’s gyrus were associated with tinnitus relief. Resting-state functional magnetic resonance imaging can provide functional information to explain and “visualize” the mechanism underlying the effect of sound therapy on the brain.

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Combined transcranial magnetic stimulation in the treatment of chronic tinnitus

Cited by 31 publications

References 28 publications

Repetitive Transcranial Magnetic Stimulation on Chronic Tinnitus: A Systematic Review and Meta-Analysis

Repetitive Transcranial Magnetic Stimulation on Chronic Tinnitus: A Systematic Review and Meta-Analysis

A Prospective Study to Evaluate Effectiveness of a Tinnitus Relief Device in a Clinical Setup

The effects of sound therapy in tinnitus are characterized by altered limbic and auditory networks

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