Combined thin-layer and gas-liquid chromatographic identification of tricyclic antidepressants in urine

Application of two chemometric methods for the determination of imipramine, amitriptyline and perphenazine in content uniformity and drug dissolution studies

“…Routine analysis methods have been usually developed for the determination of AMI, IMI and PER in either binary or multi-component mixtures by HPLC [4][5][6][7][8], gas chromatography [9,10] whereas the United States Pharmacopoeia procedure involves HPLC determination of AMI-PER in pharmaceutical formulations [11].…”