Combined Therapy of Diabetic Peripheral Neuropathy with Breviscapine and Mecobalamin: A Systematic Review and a Meta-Analysis of Chinese Studies

Abstract

Objective. A meta-analysis on combined therapy of diabetic peripheral neuropathy (DPN) with breviscapine and mecobalamin was performed to evaluate the efficacy of this therapy. Methods. Six English databases (Medline, Cochrane Library, PubMed, EMBASE, Web of Science, and CINAHL) and four Chinese databases (China National Knowledge Infrastructure, VIP Journals Database, CBM, and Wanfang database) were searched for studies on the clinical trials in which DPN was treated with breviscapine and mecobalamin, and RevMan 5.1 package was employed for analyzing pooled trials and publication bias. Results. A total of 17 articles including 1398 DPN patients were identified. Homogeneity was observed among different studies (P = 0.74). The efficacy of combined therapy with breviscapine and mecobalamin was significantly better than that in control group [P < 0.0001 (OR = 5.01, 95% CI: 3.70–6.78)]. Conclusion. Available findings suggest that the therapeutic efficacy of breviscapine combining mecobalamin is superior to mecobalamin alone, and this strategy is required to be popularized in clinical practice.

Medicinal plants in traumatic brain injury: Neuroprotective mechanisms revisited

“…This also alleviated the neuronal loss and improvement in neurological functions including learning, memory, and motor abilities mainly through inhibition of inflammation process . The protective effect of breviscapine on neurobehavioral disorders after TBI may be associated with its mechanism of improving energy metabolism, free radical scavenging, inhibition of intracellular Ca 2+ , overload, excitatory amino acid toxicity, inflammatory suppression, regulation of brain blood vessel activity, and suppression of IL‐6 expression . The protective effect of G. elata on TBI could be associated with the reduction of pro‐inflammatory cytokines, inflammation, and astrocytes' accumulation .…”

“…16 The protective effect of breviscapine on neurobehavioral disorders after TBI may be associated with its mechanism of improving energy metabolism, free radical scavenging, inhibition of intracellular Ca 2+ , overload, excitatory amino acid toxicity, inflammatory suppression, regulation of brain blood vessel activity, and suppression of IL-6 expression. 17,208,209 The protective effect of G. elata on TBI could be associated with the reduction of pro-inflammatory cytokines, inflammation, and astrocytes' accumulation. 18 Treatment with M. sylvestris prevented neurodegeneration after TBI by reducing astrocytosis, pro-inflammatory cytokines, and oxidative stress in the brain tissue.…”

The Coming Age of Flavonoids in the Treatment of Diabetic Complications

“…However, since the articles included in the study were not of high-quality, more studies should be conducted to strengthen their findings. Zheng et al [129] reviewed the therapeutic efficacy of combined therapy of diabetic peripheral neuropathy with breviscapine and mecobalamine, an endogenous coenzyme B12. They analyzed 17 studies with a total of 1398 patients including 718 treated with breviscapine and mecobalamin and 680 treated with mecobalamin alone.…”

Impact of the Herbal Breviscapine on the Pharmacokinetics of Simvastatin in Rats: The Involvement of CYP3A4

“…Every year, there are 15 million people died of cardiovascular and cerebrovascular diseases all over the world. In the recent years, there has been a large number of literature reports regarding the treatment of cardiovascular and cerebrovascular diseases with combined Chinese and Western medicines [2,3]. Evidence has shown that application of combined Chinese and Western medicines could synergize their efficacies and reduce their side effects for Chinese patients with cardiovascular and cerebrovascular disease.…”