Combined therapeutic use of AdGFPFasL and small molecule inhibitors of ceramide metabolism in prostate and head and neck cancers: a status report

Acid Ceramidase Upregulation in Prostate Cancer Cells Confers Resistance to Radiation: AC Inhibition, a Potential Radiosensitizer

“…19,20,23 Interest in AC protein levels and its role in cancer increased after studies from our lab revealed AC protein levels were elevated in primary prostate cancer tissues. 24 Seelan et al 25 reported that AC mRNA overexpression was more frequently observed in advanced Gleason-grade prostate cancers consistent with our own unpublished findings. Altogether these data suggest that AC overexpression may be characteristic of more advanced and aggressive prostate cancers.…”

Acid Ceramidase Upregulation in Prostate Cancer Cells Confers Resistance to Radiation: AC Inhibition, a Potential Radiosensitizer

“…19,20,23 Interest in AC protein levels and its role in cancer increased after studies from our lab revealed AC protein levels were elevated in primary prostate cancer tissues. 24 Seelan et al 25 reported that AC mRNA overexpression was more frequently observed in advanced Gleason-grade prostate cancers consistent with our own unpublished findings. Altogether these data suggest that AC overexpression may be characteristic of more advanced and aggressive prostate cancers.…”

Acid ceramidase upregulation in prostate cancer: role in tumor development and implications for therapy

“……”

Acid ceramidase‐mediated production of sphingosine 1‐phosphate promotes prostate cancer invasion through upregulation of cathepsin B

“…found increased cathepsin B and procathepsin B on the surface of secreted prostatomes from LNCaP and PC‐3 compared to prostatomes from healthy ejaculate 23. This study is of particular interest, as most prostate cancers have elevated AC;8 thus, we may speculate that high levels of AC in those cell lines drives upregulation and secretion of cathepsin B, as descried in this study. Extracellular cathepsin B not only exhibits an invasive phenotype in vitro, as in this study, but also in animal models.…”

Acid Ceramidase Upregulation in Prostate Cancer Cells Confers Resistance to Radiation: AC Inhibition, a Potential Radiosensitizer

“…19,20,23 Interest in AC protein levels and its role in cancer increased after studies from our lab revealed AC protein levels were elevated in primary prostate cancer tissues. 24 Seelan et al 25 reported that AC mRNA overexpression was more frequently observed in advanced Gleason-grade prostate cancers consistent with our own unpublished findings. Altogether these data suggest that AC overexpression may be characteristic of more advanced and aggressive prostate cancers.…”

Acid ceramidase upregulation in prostate cancer: role in tumor development and implications for therapy

“……”

Acid ceramidase‐mediated production of sphingosine 1‐phosphate promotes prostate cancer invasion through upregulation of cathepsin B

“…found increased cathepsin B and procathepsin B on the surface of secreted prostatomes from LNCaP and PC‐3 compared to prostatomes from healthy ejaculate 23. This study is of particular interest, as most prostate cancers have elevated AC;8 thus, we may speculate that high levels of AC in those cell lines drives upregulation and secretion of cathepsin B, as descried in this study. Extracellular cathepsin B not only exhibits an invasive phenotype in vitro, as in this study, but also in animal models.…”

Acid Ceramidase Upregulation in Prostate Cancer Cells Confers Resistance to Radiation: AC Inhibition, a Potential Radiosensitizer

“…19,20,23 Interest in AC protein levels and its role in cancer increased after studies from our lab revealed AC protein levels were elevated in primary prostate cancer tissues. 24 Seelan et al 25 reported that AC mRNA overexpression was more frequently observed in advanced Gleason-grade prostate cancers consistent with our own unpublished findings. Altogether these data suggest that AC overexpression may be characteristic of more advanced and aggressive prostate cancers.…”

Acid ceramidase upregulation in prostate cancer: role in tumor development and implications for therapy

“……”

Acid ceramidase‐mediated production of sphingosine 1‐phosphate promotes prostate cancer invasion through upregulation of cathepsin B

“…found increased cathepsin B and procathepsin B on the surface of secreted prostatomes from LNCaP and PC‐3 compared to prostatomes from healthy ejaculate 23. This study is of particular interest, as most prostate cancers have elevated AC;8 thus, we may speculate that high levels of AC in those cell lines drives upregulation and secretion of cathepsin B, as descried in this study. Extracellular cathepsin B not only exhibits an invasive phenotype in vitro, as in this study, but also in animal models.…”