Combined tendon reflex and motor evoked potential recordings in amyotrophic lateral sclerosis

Truffert, André; Sukockienė, Eglė; Desmaison, Annaïck; Ališauskienė, Miglė; Ferfoglia, Ruxandra Iancu; Guy, Nathalie

doi:10.1016/j.clinph.2022.12.013

Cited by 4 publications

(2 citation statements)

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“…15,16 Prolonged CMCT in ALS might be due to loss of upper motor neurons with the fastest conduction axons, delayed firing of spinal motor neurons due to abnormal asynchrony of corticospinal volleys descending into the anterior horn, less excitability of cortical upper motor neurons with the fastest conduction axons in response to TMS, or possibly due to a combination of these factors. 17 CMCT in patients with MS may be delayed due to myelin loss of the corticospinal tracts. 18 Therefore, although the mechanism of CMCT prolongation differs for each disease, no clear difference was observed in the degree of CMCT prolongation in the present study.…”

Section: Discussionmentioning

confidence: 99%

“…CMCT prolongation in CCM is considered to be a delayed response of anterior horn neurons due to conduction block in the corticospinal tracts 15,16 . Prolonged CMCT in ALS might be due to loss of upper motor neurons with the fastest conduction axons, delayed firing of spinal motor neurons due to abnormal asynchrony of corticospinal volleys descending into the anterior horn, less excitability of cortical upper motor neurons with the fastest conduction axons in response to TMS, or possibly due to a combination of these factors 17 . CMCT in patients with MS may be delayed due to myelin loss of the corticospinal tracts 18 .…”

Section: Discussionmentioning

confidence: 99%

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Differentiating Neurodegenerative Disease from Compressive Cervical Myelopathy Using Motor Evoked Potentials

Kamei

Nakamae

Maruyama

et al. 2023

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Study Design. A retrospective case-control study. Objective. To differentiate neurodegenerative diseases from compressive cervical myelopathy (CCM) using motor-evoked potentials (MEPs). Summary of Background Data. When considering surgery for CCM, it may be necessary to differentiate the condition from a neurodegenerative disease. Materials and Methods. A total of 30 healthy volunteers, 52 typical CCM patients with single-level compression of the spinal cord at C4-5 or C5-6, 7 patients with amyotrophic lateral sclerosis (ALS), and 12 patients with demyelinating disease of the central nervous system, including 11 patients with multiple sclerosis and 1 patient with neuromyelitis optica spectrum disorder, formed our study population. MEPs were recorded from the bilateral abductor digiti minimi (ADM) and abductor hallucis (AH) muscles using transcranial magnetic stimulation and electrical stimulation of the ulnar and tibial nerves. Central motor conduction time, peripheral conduction time, amplitude of MEPs, and frequency of F waves were evaluated. Receiver operating characteristic curve analysis was used to determine the cutoff value for distinguishing between CCM and ALS. Results. Significant differences were observed in the amplitude of MEPs and frequency of F waves evoked by peripheral nerve stimulation between patients with CCM and ALS. The MEP amplitude of AH was more accurate in differentiating between the two diseases compared with ADM (cutoff value, 11.2 mV, sensitivity, 87.5%; specificity, 85.7%). All 7 patients with ALS showed reduced frequency of F waves from ADM or AH, but none of the healthy volunteers or patients with other diseases demonstrated this finding. Moreover, there were no significant differences between CCM and demyelinating disease of the central nervous system in any of the assessments. Conclusion. The amplitude of MEPs and frequency of F waves evoked by peripheral nerve stimulation could be helpful in differentiating ALS from CCM.

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