Combined surgical and radiotherapy treatment of a mandibular ameloblastic carcinoma in a pony

Reardon, Richard; Dixon, Paddy; Kane-Smyth, Justine; Froydenlund, Tim; Booth, Susanne; Dobson, Jerome E.; Smith, Kenneth

doi:10.1111/eve.12535

Cited by 6 publications

(16 citation statements)

References 9 publications

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“…10 The mandibular ameloblastic carcinoma in this report was successfully surgically debulked and treated with radiation therapy, which has also previously been reported in the horse. 23 Based on our review of the literature, ameloblastic fibromas have not previously been reported in horses. There are numerous reports in cats 12,15 and cattle.…”

Section: Discussionmentioning

confidence: 94%

Equine odontogenic tumors: Clinical presentation, CT findings, and outcome in 11 horses

Morgan

Fiske-Jackson

Hellige

et al. 2019

Vet Radiology Ultrasound

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Odontogenic tumors present as locally invasive, slow growing, firm swellings on the face. They are rare in all species and are characterized histologically by the degree of differentiation and dental tissue of origin. Radiographic appearance is not pathognomonic for these lesions. Computed tomographic (CT) examination allows exact determination of tumor extension and aggressiveness.The objectives of this retrospective, case series study were to describe the clinical presentation, CT characteristics, and outcome in horses with histologically confirmed odontogenic tumors, and to identify imaging features suggestive of individual types of tumors. Four ameloblastomas, two ameloblastic carcinomas, three ameloblastic fibromas, and two complex odontomas were included. All but one complex odontoma presented as a single mass. All tumors were associated with maxillary or mandibular bone expansion, alveolar and cortical bone lysis, and cortical bone thinning. The majority also had cortical bone thickening and periosteal proliferation. All tumors contained some degree of mineral attenuation, although only the complex odontomas contained enamel attenuation allowing differentiation from other types of odontogenic tumors in this study.Ameloblastomas were found to have variable CT characteristics likely due to the sub-groups of ameloblastomas. Both ameloblastic carcinomas contained a mixture of mineralized and soft tissue attenuating material whereas ameloblastic fibromas were mainly composed of soft tissue attenuating material. Computed tomographic characteristics of odontogenic tumors generally indicate that they are expansile, aggressive tumors and can occur in a wide range of ages. Further investigation is needed to elucidate differences between each type of equine odontogenic tumor.

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Section: Discussionmentioning

confidence: 94%

Equine odontogenic tumors: Clinical presentation, CT findings, and outcome in 11 horses

Morgan

Fiske-Jackson

Hellige

et al. 2019

Vet Radiology Ultrasound

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“…Malignant variants of ameloblastoma are extremely rare in domestic animal species and have only been reported in three dogs (Jiménez et al ; Hatai et al ; Aydogan et al ) and two horses (De Cock et al ; Reardon et al ) to date. None of these cases were associated with metastasis.…”

Section: Introductionmentioning

confidence: 99%

Surgical treatment of a mandibular ameloblastic carcinoma with metastases to the mandibular lymph nodes in a pony

Derham

Kushnir

Hoey

et al. 2019

Equine Veterinary Education

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A 4-year-old Connemara filly was presented with a rapidly growing oral mass on the right rostrolateral mandible and a right mandibular lymphadenopathy. Radiographs of the rostral mandible revealed a lytic, infiltrative mass consistent with soft tissue and mineralised material, and displacement of tooth 403. A biopsy showed characteristic histopathological features of an ameloblastic carcinoma. Subsequent FNA of the right abnormally firm and enlarged mandibular lymph node confirmed the metastatic spread. Computed tomography of the head was performed for surgical planning, including sentinel lymph node mapping to rule out other lymph node involvement. An aggressive lesion, consistent with soft tissue of the rostral right mandible was identified with intralesional contrast injection showing drainage of contrast within the right mandibular lymph nodes (Sentinel node). Based on the infiltrative and destructive nature reported in ameloblastic carcinoma in humans, a rostral mandibulectomy was performed, along with complete mandibular lymphadenectomy. The horse recovered uneventfully from surgery. In the early post-operative period marked lymphoedema of the ventral mandibular region was observed, which resolved 4-5 days post-operatively. Optimal cosmesis was maintained post-operatively, and no recurrence has been observed to date-12 months post-surgery.

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“…; Reardon et al . ), cementoma (Pirie and Dixon ), ameloblastic fibro‐odontoma (Knowles et al . ) and complex odontoma (Dubielzig et al .…”

Section: Introductionmentioning

confidence: 99%

Sclerosing odontogenic carcinoma in the mandible of a horse

Oliver

Kelly

Sharpe

et al. 2018

Equine Veterinary Education

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Summary A 15‐year‐old Cob mare was presented for investigation of a mandibular mass. Radiography identified an oval‐shaped mass occupying the intramandibular space, with a heterogeneous osseous opacity throughout the left hemimandible. Histopathology combined with immunohistochemistry was consistent with a diagnosis of sclerosing odontogenic carcinoma, which to date has only been described, rarely, in human patients. The mass was removed using a mandibular‐sparing surgical technique allowing preservation of the dental arcade. Follow‐up 5 years after surgery confirmed no signs of regrowth. This case report describes the successful treatment of a previously unreported mandibular neoplasm in the horse.

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Combined surgical and radiotherapy treatment of a mandibular ameloblastic carcinoma in a pony

Cited by 6 publications

References 9 publications

Equine odontogenic tumors: Clinical presentation, CT findings, and outcome in 11 horses

Equine odontogenic tumors: Clinical presentation, CT findings, and outcome in 11 horses

Surgical treatment of a mandibular ameloblastic carcinoma with metastases to the mandibular lymph nodes in a pony

Sclerosing odontogenic carcinoma in the mandible of a horse

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