Combined subunit‐specific and unspecific inhibition of NMDA receptors triggers distinct cortical c‐fos expression patterns

Abstract

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Facilitated c-Fos Induction in Mice Deficient for the AMPA Receptor-Associated Protein Ckamp44

“…1d). Strikingly, this c-Fos expression pattern was very similar with the MK-801-induced c-Fos expression pattern in mice lacking the GluN2A subunit of NMDARs (Grin2a -/-) (n = 6), which exhibit as well strong activation of the hippocampus, as shown previously (Inta et al 2012) (Fig. 1e).…”

Region-Specific Enhancement of c-fos Expression by Combined Treatment With NMDA Receptor Agonists and Antagonists With Antidepressant Potential

“…The currently reported enhanced network activity may be triggered by excessive glutamate release mediated by MK-801, which further increases NMDAR function induced by the examined allosteric modulators. We previously described a similar augmentation of MK-801 by GluN2-specific blockade: both GluN2B antagonism combined with MK-801 or MK-801 given to GluN2A KO mice stimulated specific forebrain areas, resulting in the "de novo" activation of specific brain regions (Inta et al, 2012). In that case, one possible explanation is that MK-801 acts not only on forebrain NMDARs containing the GluN2A/GluN2B subunits but mainly on predominantly extracortical GluN2C/GluN2D-containing NMDARs (Kotermanski, Wood and Johnson, 2009), suggesting a cumulative effect.…”

“…The brains were removed and postfixed for 24 hours, then cut into 5-µm-thick coronal sections. Substance dosages and time of killing were based on previous research (Donello et al, 2019;Inta et al, 2012). All experiments were approved by the local Committee on Animal Care and Use and in accordance with the local Animal Welfare Act and the European Communities Council Directive 2010/63.…”