Combined Stimulation of Nasal Polyp Fibroblasts With Poly IC, Interleukin 4, and Tumor Necrosis Factor α Potently Induces Production of Thymus- and Activation-Regulated Chemokine

Nonaka, Manabu; Ogihara, Nozomu; Fukumoto, Atsushi; Sakanushi, Atsuko; Pawankar, Ruby; Yagi, Toshiaki

doi:10.1001/archotol.134.6.630

Cited by 2 publications

(2 citation statements)

References 32 publications

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“…The same author found that the stimulation of NPDF with poly IC, poly IC and TNF-α, poly IC and IL-4, or IL-4 and TNF-α induced a significant increase in the expression of TARC. Furthermore, the simultaneous exposure of cells to poly IC, IL-4, and TNF-α induced an even higher increase in the expression of CCL17 (TARC) [96,97]. In view of these findings, IL-4 seems fundamental in the induction of CCL17 (TARC) expression by NPDF and in the regulation of T2 cell chemotaxis.…”

Section: Chemokine C-c Motif Ligand 2 (Ccl2)mentioning

confidence: 86%

Role of Fibroblasts in Chronic Inflammatory Signalling in Chronic Rhinosinusitis with Nasal Polyps—A Systematic Review

Palacios-García

Porras-González

Moreno‐Luna

et al. 2023

JCM

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Chronic rhinosinusitis with nasal polyps (CRSwNP) is an inflammatory disease of the nose and paranasal sinuses characterized by the presence of nasal polyps. The symptoms produced by the presence of nasal polyps such as nasal obstruction, nasal discharge, facial pain, headache, and loss of smell cause a worsening in the quality of life of patients. The source of the nasal polyps remains unclear, although it seems to be due to a chronic inflammation process in the sinonasal mucosa. Fibroblasts, the main cells in connective tissue, are intimately involved in the inflammation processes of various diseases; to this end, we carried out a systematic review to evaluate their inflammatory role in nasal polyps. Thus, we evaluated the main cytokines produced by nasal polyp-derived fibroblasts (NPDF) to assess their involvement in the production of nasal polyps and their involvement in different inflammatory pathways. The results of the review highlight the inflammatory role of NPDF through the secretion of various cytokines involved in the T1, T2, and T3 inflammatory pathways, as well as the ability of NPDF to be stimulated by a multitude of substances. With these findings, the fibroblast is positioned as a new potential therapeutic target in the treatment of CRSwNP.

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Section: Chemokine C-c Motif Ligand 2 (Ccl2)mentioning

confidence: 86%

Role of Fibroblasts in Chronic Inflammatory Signalling in Chronic Rhinosinusitis with Nasal Polyps—A Systematic Review

Palacios-García

Porras-González

Moreno‐Luna

et al. 2023

JCM

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“…Fibroblasts are key players in the epithelial growth and repair process and may serve to promote the inflammatory state in CRS. Fibroblast cultures derived from polyps express the lymphocyte chemokine thymus and activation-regulated chemokine (CCL-17) when stimulated with agonists for TLR2 to TLR5, IL-4, or tumor necrosis factor-α [51•,52,53]. Interestingly, recent evidence suggests that TLRs on epithelial cells may activate signaling cascades using the epidermal growth factor receptor, supporting the tight association between innate immunity and injury repair [54–56].…”

Section: Crs and Epithelial Innate Immunitymentioning

confidence: 99%

The role of innate immunity in the pathogenesis of chronic rhinosinusitis

Lane

2009

Curr Allergy Asthma Rep

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Chronic rhinosinusitis (CRS) is a heterogeneous inflammatory condition with a multifactorial basis. Infectious triggers of CRS have been proposed, but demonstration remains elusive. Evolving research suggests that abnormal host mucosal immune responses, rather than specific pathogens themselves, may underlie the chronic inflammatory state. Despite constant contact with airborne particulates and microorganisms, the sinonasal epithelium maintains mucosal homeostasis through innate and adaptive immune mechanisms that eliminate potential threats. Innate immunity encompasses a broad collection of constitutive and inducible processes that can be nonspecific or pathogen directed. Some innate immune pathways are closely intertwined with tissue growth and repair. The persistent inflammation observed in CRS may result from a pathologic imbalance in innate immune interactions between the host and the environment. Impairment of critical innate immune protection renders the sinonasal mucosal surface susceptible to colonization and potential injury, stimulating the prominent adaptive immune response that characterizes CRS.

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Combined Stimulation of Nasal Polyp Fibroblasts With Poly IC, Interleukin 4, and Tumor Necrosis Factor α Potently Induces Production of Thymus- and Activation-Regulated Chemokine

Cited by 2 publications

References 32 publications

Role of Fibroblasts in Chronic Inflammatory Signalling in Chronic Rhinosinusitis with Nasal Polyps—A Systematic Review

Role of Fibroblasts in Chronic Inflammatory Signalling in Chronic Rhinosinusitis with Nasal Polyps—A Systematic Review

The role of innate immunity in the pathogenesis of chronic rhinosinusitis

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