Combined Serum DKK3 and Circulating CD133 Cells as Prognostic Biomarkers for Ovarian Cancer Patients

Nie, Xin; He, Fang; Lan, Chong; Niu, Jumin; Pu, Xia

doi:10.2147/ott.s288191

Cited by 7 publications

(4 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In addition, the combination of novel biomarkers has been used to great advantage. As mentioned in an article by Nie et al [31], the combination of serum DKK3 and circulating CD133 cells can provide a reliable prognosis for OC patients.…”

Section: Combination Of Biomarkers and Ovarian Cancer Prognosismentioning

confidence: 92%

Serum Tumor Markers Combined with 18F-FDG PET/CT Volumetric Metabolic Parameters in the Prognosis of Ovarian Cancer

Yang¹,

Guan²,

Liang³

et al. 2023

JBM

View full text Add to dashboard Cite

Ovarian cancer (OC) is the most fatal gynecological malignancy, and identifying reliable prognostic indicators can help guide therapeutic treatment. Various tumor marker-guided treatment regimens can considerably improve patient prognosis with a better understanding of the molecular underpinnings of ovarian cancer recurrence and metastasis. Fluorine-18-fluorodeoxyglucose Positron emission tomography/computed tomography (18F-FDG PET/CT) is a molecular imaging tool that provides anatomical and functional information about the tumor, and its volume-based metabolic parameters allow for quantifiable observation of ovarian cancer recurrence, prognosis, and therapeutic efficacy. The combined utilization of serological and radiologic markers has been found to provide increased clinical benefit. This article reviewed the predictive value of serum tumor markers and 18F-FDG PET/CT volumetric metabolic parameters for the prognosis of patients with ovarian cancer.

show abstract

Section: Combination Of Biomarkers and Ovarian Cancer Prognosismentioning

confidence: 92%

Serum Tumor Markers Combined with 18F-FDG PET/CT Volumetric Metabolic Parameters in the Prognosis of Ovarian Cancer

Yang¹,

Guan²,

Liang³

et al. 2023

JBM

View full text Add to dashboard Cite

show abstract

“…We used the same method as in our previous study 19 ; serum DKK3 levels were measured by enzyme-linked immunosorbent assay (ELISA), according to the manufacturer's instructions (R&D Systems, Shanghai, China).…”

Section: Serum Dkk3 Level Determinationmentioning

confidence: 99%

Effect of secretory DKK3 on circulating CD56^bright natural killer cells in patients with liver cancer

et al. 2023

Self Cite

View full text Add to dashboard Cite

Background Liver cancer seriously threatens human health. Natural killer (NK) cells are an important part of the innate immune system and have strong anti-tumor ability. Immunotherapy based on NK cells has become a hot topic in the treatment of liver cancer. Methods In this study, we checked the serum DKK3 (sDKK3) and circulating CD56bright NK cells using ELISA and flow cytometry, respectively, in the blood of liver cancer patients. The effect on recombinant human DKK3 (rhDKK3) on CD56bright NK cells was analyzed in vitro. Results We found low levels of sDKK3 in liver cancer patients and a negative correlation between sDKK3 and circulating CD56bright NK cells. In addition, we found that DKK3 induced the differentiation and improved the cytotoxicity of CD56bright NK cells for the first time. It could be used as an agonist for NK cell-based immunotherapy. Conclusions Improving the clinical efficacy of NK cells through DKK3 will become a new strategy for cancer immunotherapy.

show abstract

“…The frequency of DKK-3 promoter hypermethylation varies from 26% (pleural mesothelia) to 61% (breast carcinoma). [7,50] Suppression of cell proliferation The overexpression of DKK-3 in hepatoma and cervical cancer cells diminishes cell proliferation in vitro [51,52] Response to chemotherapy [ 15,53] Serum DKK-3 is a prognosis biomarker DKK-3 levels are negatively correlated with the number of CD133+ circulating tumor cells in ovarian cancer [54] Regulation of the tumor immune microenvironment DKK-3 expression correlates with infiltrating CD8+ lymphocytes and macrophages in HPV-positive HNSCC and stimulates NF-κB signaling in macrophages [55]…”

Section: Downregulated Expression In Cancer Cellsmentioning

confidence: 99%

“…Administration of DKK-3 increased both the transcript and protein levels of the epithelial marker E-cadherin and reduced mesenchymal markers (Vimentin, N-cadherin, and Snail) suggesting that DKK-3 inhibits the epithelial–mesenchymal transition (EMT). This observation is significant since it suggests the combination of both CD133+ and DKK-3 markers could have prognosis value ( Figure 4 , left panel) [ 54 ].…”

Section: Dkk-3 Has a Dual Role In Cancer As Either A Tumor Suppressor...mentioning

confidence: 99%

The Multifaceted Role of Human Dickkopf-3 (DKK-3) in Development, Immune Modulation and Cancer

Mourtada,

Thibaudeau,

Wasylyk

et al. 2023

Cells

View full text Add to dashboard Cite

The human Dickkopf (DKK) family includes four main secreted proteins, DKK-1, DKK-2, DKK-3, and DKK-4, as well as the DKK-3 related protein soggy (Sgy-1 or DKKL1). These glycoproteins play crucial roles in various biological processes, and especially modulation of the Wnt signaling pathway. DKK-3 is distinct, with its multifaceted roles in development, stem cell differentiation and tissue homeostasis. Intriguingly, DKK-3 appears to have immunomodulatory functions and a complex role in cancer, acting as either a tumor suppressor or an oncogene, depending on the context. DKK-3 is a promising diagnostic and therapeutic target that can be modulated by epigenetic reactivation, gene therapy and DKK-3-blocking agents. However, further research is needed to optimize DKK-3-based therapies. In this review, we comprehensively describe the known functions of DKK-3 and highlight the importance of context in understanding and exploiting its roles in health and disease.

show abstract

Combined Serum DKK3 and Circulating CD133 Cells as Prognostic Biomarkers for Ovarian Cancer Patients

Cited by 7 publications

References 23 publications

Serum Tumor Markers Combined with 18F-FDG PET/CT Volumetric Metabolic Parameters in the Prognosis of Ovarian Cancer

Serum Tumor Markers Combined with 18F-FDG PET/CT Volumetric Metabolic Parameters in the Prognosis of Ovarian Cancer

Effect of secretory DKK3 on circulating CD56^bright natural killer cells in patients with liver cancer

The Multifaceted Role of Human Dickkopf-3 (DKK-3) in Development, Immune Modulation and Cancer

Contact Info

Product

Resources

About

Combined Serum DKK3 and Circulating CD133 Cells as Prognostic Biomarkers for Ovarian Cancer Patients

Cited by 7 publications

References 23 publications

Serum Tumor Markers Combined with 18F-FDG PET/CT Volumetric Metabolic Parameters in the Prognosis of Ovarian Cancer

Serum Tumor Markers Combined with 18F-FDG PET/CT Volumetric Metabolic Parameters in the Prognosis of Ovarian Cancer

Effect of secretory DKK3 on circulating CD56bright natural killer cells in patients with liver cancer

The Multifaceted Role of Human Dickkopf-3 (DKK-3) in Development, Immune Modulation and Cancer

Contact Info

Product

Resources

About

Effect of secretory DKK3 on circulating CD56^bright natural killer cells in patients with liver cancer