Combined search for anti–β2-glycoprotein i and anticardiolipin antibodies in antiphospholipid syndrome: Contribution to diagnosis

Sanmarco, Marielle; Roll, Patrice; Gayet, S.; Oksman, F; Johanet, Catherine; Escande, Aurélie; Cohen, Jacques H. M.; Chevailler, Alain; Goetz, Joëlle; Humbel, René‐Louis; Sibilia, Jean

doi:10.1016/j.lab.2004.04.011

Cited by 8 publications

(4 citation statements)

References 20 publications

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“…We demonstrated that the presence of medium or high titre of IgG anti 2 GPI was an independent risk factor for the development of a new thrombotic episode in patients with a previous thrombosis and also for the first episode in asymptomatic ones [88]. These antibodies are present most of times associated with LA or aCL, as was seen by the low frequency of them in patients with history of thrombosis presenting LA and aCL negative results [89][90][91]. Although they are more specific for APS [92,93], they become positive in some chronic infections like leprosy [94].…”

Section: Anti 2 Gpi Testingmentioning

confidence: 54%

Laboratory Criteria of Antiphospholipid Syndrome Need to be Updated or Strictly Followed?~!2009-09-24~!2009-09-28~!2010-03-11~!

Martinuzzo¹

2010

TOAUTOJ

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The antiphospholipid syndrome is a very relevant disease that implicates different clinical features and laboratory criteria. Regarding laboratory diagnosis, it has been established in the last consensus that tests included are lupus anticoagulant (LA), anti cardiolipin (aCL) and anti 2 glycoprotein I antibodies (anti 2 GPI) of IgG or IgM isotype at medium to high titres. There is not one unique or a gold standard test for APS, so laboratory diagnosis is one of the more important problems. Considering LA testing, new guidelines have been recently published. They include not only the selection of coagulation tests, but also important recommendations about preanalytical variables, mixing and confirmatory studies interpretation, and cut off calculations. Taking into account solid phase assays, the major problem is the low reproducibility and the high inter assays variation. This problem has been recognized early with aCL. Despite many efforts such as the introduction of polyclonal and monoclonal standards, laboratory workshops, etc, the situation is still complicated. This problem was supposed to be solved when anti 2 GPI were introduced, but many collaborative studies and quality control surveys assessment have also demonstrated a lot of problems in standardization. The need of reference materials for LA and solid phase assays has been recognized many years ago but there is no clear advance in this line. Another important aspect is the fact that none of these tests are specific for APS, so they can be present in many clinical settings. Recent advances have been done by developing assays to detect anti domain I 2 GPI antibodies that could be more specific. It is hoped that in the near future, by worldwide collaborative actions, problems on laboratory diagnosis of APS will be overcome.

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Section: Anti 2 Gpi Testingmentioning

confidence: 54%

Laboratory Criteria of Antiphospholipid Syndrome Need to be Updated or Strictly Followed?~!2009-09-24~!2009-09-28~!2010-03-11~!

Martinuzzo¹

2010

TOAUTOJ

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“…En effet, l'hétérogénéité des profils d'anticorps dans le SAPL implique de rechercher plusieurs types d'APL [10][11][12]3]. Si les anticorps anti-␤2-GPI paraissent plus spécifiques du SAPL, leur recherche ne remplace pas celle des ACL et le consensus de Sydney a retenu les deux types d'anticorps dans les critères de classification du SAPL [1].…”

Section: Discussionunclassified

Dosage multiplex des auto-anticorps antiphospholipides sur l’automate FIDIS™

Lakomy

Audia

Buliard

et al. 2010

Immuno-analyse & Biologie Spécialisée

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“…In addition such a group with multi-reactivity is suspected of having higher levels of high avidity aβ2-GPI able to recognize the G40-44 epitope present in β2-GPI domain I [126]. Counter to this, association of clinical APS with an exclusive positivity is higher for LA, followed by the aβ2-GPI positivity and then by the aCL positivity [127]. The cases of exclusive aΒ2-GPI positivity are still exceptional though [128].…”

Section: Association With Acl and Lamentioning

confidence: 99%

News and meta-analysis regarding anti-Beta 2 glycoprotein I antibodies and their determination

Bettacchioli¹,

Salma²,

Renaudineau

2019

Clinical Immunology

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Combined search for anti–β2-glycoprotein i and anticardiolipin antibodies in antiphospholipid syndrome: Contribution to diagnosis

Cited by 8 publications

References 20 publications

Laboratory Criteria of Antiphospholipid Syndrome Need to be Updated or Strictly Followed?~!2009-09-24~!2009-09-28~!2010-03-11~!

Laboratory Criteria of Antiphospholipid Syndrome Need to be Updated or Strictly Followed?~!2009-09-24~!2009-09-28~!2010-03-11~!

Dosage multiplex des auto-anticorps antiphospholipides sur l’automate FIDIS™

News and meta-analysis regarding anti-Beta 2 glycoprotein I antibodies and their determination

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