Combined restraint and cold stress in rats: effects on memory processing in passive avoidance task and on plasma levels of ACTH and corticosterone

Klenerová, Věra; Jurčovičová, J; Kaminskyi, Oleksii; Šída, Pavel; Krejcí, I; Hliňák, Z; Hynie, S.

doi:10.1016/s0166-4328(02)00401-1

Cited by 35 publications

(25 citation statements)

References 38 publications

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“…and Lou et al . found that the plasma ACTH and corticosterone levels were elevated in rats exposed to WIRS [18, 19]. Other studies using different models of stress, such as restraint or cold restraint stress, also demonstrated a similar finding, i.e.…”

Section: Discussionmentioning

confidence: 55%

“…The elevation of plasma corticosterone in stressed rats noted in the present study is in agreement with the results of al-Shabanah et al ., Ainsah et al ., Klenerová et al ., Lou et al . and Nur Azlina and Nafeeza [1, 8, 18, 19, 24]. This elevation could be explained on the basis that stress induces the activation of the HPA axis causing increased secretion of pituitary endorphins, ACTH and adrenal corticosteroids such as corticosterone.…”

Section: Discussionmentioning

confidence: 99%

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The effects of palm vitamin E on stress hormone levels and gastric lesions in stress-induced rats

Ibrahim¹,

Kamisah²,

Nafeeza³

et al. 2012

aoms

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IntroductionThis study examines the effects of palm vitamin E (PVE) or α-tocopherol (α-TF) supplementation on adrenocorticotropin hormone (ACTH), corticosterone and gastric lesions in rats exposed to water-immersion restraint stress (WIRS).Material and methodsSixty male Sprague-Dawley rats (200-250 g) were divided into three groups. Group I: 20 rats as a control group were given a normal diet. Group II: 20 rats received oral supplementation of PVE at 60 mg/kg body weight. Group III: 20 rats received oral supplementation of α-TF at 60 mg/kg body weight. After the treatment period of 28 days, each group was further subdivided into two groups: 10 rats not exposed to stress, and the other 10 rats subjected to WIRS for 3.5 h. Blood samples were taken to measure the ACTH and corticosterone levels. The rats were then sacrificed and the stomach excised and opened along the greater curvature and examined for lesions.ResultsRats exposed to WIRS had lesions in their stomach mucosa. Our findings showed that dietary supplementation of PVE or α-TF was able to reduce gastric lesions significantly in comparison to the stressed controls. The WIRS increased plasma ACTH and corticosterone significantly. Palm vitamin E and α-TF treatments reduced these parameters significantly compared to the stressed controls.ConclusionsSupplementation with either PVE or α-TF reduces the formation of gastric lesions, probably by inhibiting the elevation of ACTH and corticosterone levels induced by stress.

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Section: Discussionmentioning

confidence: 55%

Section: Discussionmentioning

confidence: 99%

The effects of palm vitamin E on stress hormone levels and gastric lesions in stress-induced rats

Ibrahim¹,

Kamisah²,

Nafeeza³

et al. 2012

aoms

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show abstract

“…Repeated habituation is known to reduce the novelty-induced arousal response, and under these circumstances, stress can have detrimental effects on memory. There are reports that if an animal is placed in a stressful environment immediately following training, performance in delayed recall may be impaired (Cabib and Castellano, 1997;Diamond et al, 2006;Klenerova et al, 2003;Meere and Borrell, 1988;Rudy, 1996;Trneckova et al, 2005). Overall, these findings suggest that the level of arousal or stress experienced by the animal during training is an important factor in determining whether stress will enhance or impair memory consolidation.…”

Section: Opposite Effect Of the Stressor On The Consolidation Of Recomentioning

confidence: 99%

Arousal and Stress Effects on Consolidation and Reconsolidation of Recognition Memory

Maroun

Akirav

2007

Neuropsychopharmacol

121

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This study examined the effects of the arousal level of the rat and exposure to a behavioral stressor on consolidation and reconsolidation of a nonaversive learning paradigm, the object recognition task. Learning was tested under two arousal conditions: no previous habituation to the experimental context (high novelty stress/arousal level) or extensive prior habituation (reduced novelty stress/arousal level). Results indicated that in the habituated rats, exposure to an out-of-context stressor (ie, elevated platform stress) impaired longterm consolidation and reconsolidation of object recognition. RU-486, a glucocorticoid receptor (GR) antagonist, infused into the basolateral amygdala (BLA), reversed the impairing effects of the stressor. In contrast, the nonhabituated aroused rats were impaired when consolidation was examined, but their memory was intact following reactivation of the memory trace. Exposure of nonhabituated rats to an out-of-context stressor enhanced the long-term consolidation of recognition memory, but impaired reconsolidation, and the effects were reversed by a GR antagonist infused into the BLA. Additionally, nonhabituated control rats showed intact retrieval following microinfusion of propranolol to the BLA immediately after the training, suggesting an involvement of beta-adrenoceptors in the BLA in the arousal-induced impairment of consolidation. These findings demonstrate opposite effects, detrimental and facilitative, of arousal and stress on memory consolidation and reconsolidation. In addition, the data suggests that although some general features underlie consolidation and reconsolidation, there is a possible dissimilarity between the two processes, which is dependent on the arousal level of the animal during training.

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“…[30][31][32] Since there is clearly a relationship between stress, glucocorticoid levels, and memory impairment, 33,34) the regulation of glucocorticoid levels imposed by the NTD may play a role in improving scopolamine-induced amnesia. Further study is necessary to elucidate the mechanism of action of the NTD.…”

Section: Discussionmentioning

confidence: 99%

Effect of a Nutritive-Tonic Drink on Scopolamine-Induced Memory Impairment in Mice

Sakata

Chida

Ishige

et al. 2005

Biological & Pharmaceutical Bulletin

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Combined restraint and cold stress in rats: effects on memory processing in passive avoidance task and on plasma levels of ACTH and corticosterone

Cited by 35 publications

References 38 publications

The effects of palm vitamin E on stress hormone levels and gastric lesions in stress-induced rats

The effects of palm vitamin E on stress hormone levels and gastric lesions in stress-induced rats

Arousal and Stress Effects on Consolidation and Reconsolidation of Recognition Memory

Effect of a Nutritive-Tonic Drink on Scopolamine-Induced Memory Impairment in Mice

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