Combined repeated-dose toxicity study of silver nanoparticles with the reproduction/developmental toxicity screening test

Hong, Jeong-Sup; Kim, Suhyon; Lee, Sangeun; Jo, Eunhye; Lee, Byung-Cheun; Yoon, Junheon; Eom, Ig-Chun; Kim, Hyun-Mi; Kim, Pilje; Choi, Kyunghee; Lee, Moo Yeol; Seo, Yeong-Rok; Kim, Younghun; Lee, Yeonjin; Choi, Jae‐Suk; Park, Kwangsik

doi:10.3109/17435390.2013.780108

Cited by 65 publications

(41 citation statements)

References 26 publications

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“…Our results show that 6-19-day oral repeated dosing of AgNPs during pregnancy caused oxidative stress in maternal hepatic tissues, as evidenced by a decrease in liver CAT and ↓GSH activities at a dose of 0.5 and 1 mg/kg/day, but did not cause any significant developmental toxicity in same dose in Swiss Albino mice. In contrast, no changes in liver function parameters or histopathology were reported in past combined repeated-dose toxicity study of AgNPs with reproductive/developmental toxicity [25]. Hadrup et al [26] also reported that 28-day repeated oral dose of 9 mg AgNPs/kg/day did not induce any hepatotoxic effects in rats.…”

Section: Discussionmentioning

confidence: 88%

Particle Size Dependent Teratogenicity of Silver Nanoparticles in Mice

Prakash

Singh

Pratap

et al. 2016

MOJAP

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Nanoparticles because of their unique properties have widespread application in biomedicine and many industrial sectors. The present study was undertaken to determine the potential effects of AgNPs of different size on pregnant dams and fetal development after maternal exposure on gestational days (GD) 6-19 in mice. AgNPs, of 20nm and 1300 nm respectively were administered to pregnant mice by oral gavages at concentrations of 0.5 mg/kg/day and 1 mg/kg/day. All dams were subjected to Cesarean section on GD 20. The fetuses were evaluated for signs of embryotoxic and teratogenic effects. AgNPs caused a decrease in Catalase and Reduced Glutathione activities at ≥ 0. 5 mg/kg/day and a reduction in glutathione content at 1 mg/kg/day in maternal liver tissues. However, no treatment-related deaths or clinical signs were observed in any of the animals treated with AgNPs. Fetal liver tissue showed significant decrease in Catalase and Reduced Glutathione activities. Histomorphological alterations in the fetal liver were observed at 1300nm particle group which were exacerbated in 20 nm group. The results show that a repeated oral dose of AgNPs during pregnancy caused oxidative stress in fetal hepatic tissue which is not only dose dependent but also depends on the particle size.

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Section: Discussionmentioning

confidence: 88%

Particle Size Dependent Teratogenicity of Silver Nanoparticles in Mice

Prakash

Singh

Pratap

et al. 2016

MOJAP

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“…In addition, nanosilver is sometimes intentionally included in consumer products for preventing bacterial contamination during their use. According to Hong et al (2013), nanosilver is also considered as a potential additive to animal feed.…”

Section: Biocidal Productsmentioning

confidence: 99%

“…Very recently, the results of a combined repeated-dose toxicity study with the Reproduction / Developmental Toxicity Screening Toxicity Test according to OECD TG 422 for Ag-NP became available (Hong et al 2013). Citrate capped Ag-NP (8 nm) were applied by gavage at doses of 62.5, 125 and 250 mg/kg bw/d to males 14 days prior to mating and 28 days during and after mating, and to females 14 days prior to mating, during mating and gestation, and during 4 days of lacatation.…”

Section: In Vivo Reproductive and Developmental Toxicitymentioning

confidence: 99%

Potential risks and benefits of nanotechnology: perceptions of risk in sunscreens

Wright

2016

Medical Journal of Australia

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“…66 In addition, oral administrations of silver NPs (250 mg/kg) caused a relatively low toxic effect. 67 Unpublished 90-day repeated oral-dose and genotoxicity data from our previous studies are briefly summarized, as follows. The ZnO NPs did not cause any significant changes at the endpoints of repeated-dose toxicity, including clinical observation, functional observation, body-weight gain, water and food consumption, urinalysis, hematology, serum biochemistry, organ weight, toxicokinetic study, tissue distribution, and histopathology in the repeated study.…”

mentioning

confidence: 99%

Prenatal development toxicity study of zinc oxide nanoparticles in rats

An¹,

Hong²,

Park³

et al. 2014

IJN

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This study investigated the potential adverse effects of zinc oxide nanoparticles ([ZnO SM20(+) NPs] zinc oxide nanoparticles, positively charged, 20 nm) on pregnant dams and embryo–fetal development after maternal exposure over the period of gestational days 5–19 with Sprague-Dawley rats. ZnO SM20(+) NPs were administered to pregnant rats by gavage at 0, 100, 200, and 400 mg/kg/day. All dams were subjected to a cesarean section on gestational day 20, and all of the fetuses were examined for external, visceral, and skeletal alterations. Toxicity in the dams manifested as significantly decreased body weight after administration of 400 mg/kg/day NPs; reduced food consumption after administration of 200 and 400 mg/kg/day NPs; and decreased liver weight and increased adrenal glands weight after administration of 400 mg/kg/day NPs. However, no treatment-related difference in: number of corpora lutea; number of implantation sites; implantation rate (%); resorption; dead fetuses; litter size; fetal deaths and placental weights; and sex ratio were observed between the groups. On the other hand, significant decreases between treatment groups and controls were seen for fetal weights after administration of 400 mg/kg/day NPs. Morphological examinations of the fetuses demonstrated significant differences in incidences of abnormalities in the group administered 400mg/kg/day. Meanwhile, no significant difference was found in the Zn content of fetal tissue between the control and high-dose groups. These results showed that oral doses for the study with 15-days repeated of ZnO SM20(+) NPs were maternotoxic in the 200 mg/kg/day group, and embryotoxic in the 400 mg/kg/day group.

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Combined repeated-dose toxicity study of silver nanoparticles with the reproduction/developmental toxicity screening test

Cited by 65 publications

References 26 publications

Particle Size Dependent Teratogenicity of Silver Nanoparticles in Mice

Particle Size Dependent Teratogenicity of Silver Nanoparticles in Mice

Potential risks and benefits of nanotechnology: perceptions of risk in sunscreens

Prenatal development toxicity study of zinc oxide nanoparticles in rats

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