Combined pulmonary fibrosis and emphysema in hypersensitivity pneumonitis

Soumagne, Thibaud; Pana-Katatali, Héloïse; Degano, Bruno; Dalphin, Jean‐Charles

doi:10.1136/bcr-2015-211560

Cited by 18 publications

(15 citation statements)

References 10 publications

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“…Long-term exposure can lead to pulmonary fibrosis, respiratory failure, pulmonary hypertension, and pulmonary heart disease [12]. Xinjiang is an area with multi-ethnic inhabitants.…”

Section: Discussionmentioning

confidence: 99%

The correlation between pulmonary fibrosis and methylation of peripheral Smad3 in cases of pigeon breeder’s lung in a Chinese Uygur population

Ding

Li³

et al. 2017

Oncotarget

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Smad3 is a key protein in the transforming growth factor-beta (TGF-β)/Smad signaling pathway, which is involved in fibrosis in many organs. We investigated the relationship between Smad3 gene methylation and pulmonary fibrosis in pigeon breeder's lung (PBL). Twenty Uygur PBL patients with pulmonary fibrosis in Kashi between October 2015 and March 2016 were enrolled. Twenty PBL-free pigeon breeders and 20 healthy non-pigeon breeders enrolled during the same period constituted the negative and normal control groups, respectively. Participants’ data and peripheral blood samples were collected, and three Smad3 CpG loci were examined. Distributions of CpG_2 and CpG_4 methylation rates did not differ across groups, whereas distributions of CpG_3 methylation rates were significantly different among the three groups. The CpG_3 methylation rate was significantly lower in the patient group than in the negative control group. Smad3 mRNA expression was significantly higher in the patient group than in the negative control group but did not differ between the two control groups. TGF-βlevels were significantly higher in the patient group than in either control group (both P<0.01). Smad3 gene methylation and Smad3 mRNA expression were negatively correlated, with a correlation coefficient of -0.84. The number of pigeons bred during the preceding three months was positively correlated with Smad3 mRNA expression, with a correlation coefficient of 0.77. Smad3 gene hypomethylation might promote pulmonary fibrosis in Uygur PBL patients via increased Smad3 mRNA expression. Smad3 methylation, Smad3 mRNA expression and TGF-β level were correlated with the number of pigeons bred by patients.

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“…Long-term exposure can lead to pulmonary fibrosis, respiratory failure, pulmonary hypertension, and pulmonary heart disease [12]. Xinjiang is an area with multi-ethnic inhabitants.…”

Section: Discussionmentioning

confidence: 99%

The correlation between pulmonary fibrosis and methylation of peripheral Smad3 in cases of pigeon breeder’s lung in a Chinese Uygur population

Ding

Li³

et al. 2017

Oncotarget

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“…É um importante fitopatógeno, sendo muito prejudicial para as culturas vegetais . Para os seres humanos e animais, nem todas as cepas são patogênicas, entretanto algumas cepas podem provocar ocasionalmente feo-hifomicose cutânea e cerebral independentemente do estado imunitário do hospedeiro (Soumagne et al, 2015;Maduri et al, 2015).…”

Section: Principais Espécies Patogênicasunclassified

Cladosporium spp: Morfologia, infecções e espécies patogênicas

2017

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ResumoO gênero Cladosporium spp compreende grande número de fungos dematiáceos com distribuição mundial e que estão entre os fungos de ambiente mais comuns. São frequentemente isolados como contaminantes, no entanto, algumas espécies são patogênicas e toxigênicas para os seres humanos, estando associados a infecções superficiais da pele e dos tecidos moles e incluem sepse disseminada com elevada mortalidade. Cladoporium spp são aero-alérgenos e causam graves doenças alérgicas do trato respiratório, bem como lesões intrabrônquicas. Atualmente, as espécies de Cladosporium spp de interesse médico associadas com doença humana são C. cladosporioides, C. herbarum, C. oxysporum e C. sphaerospermum. No caso de infecções por Cladosporium spp, a terapia é prolongada e varia de acordo com a síndrome clínica. Sendo essencial o conhecimento a cerca desse gênero, para melhor diagnóstico e tratamento adequado. Esta revisão de literatura teve como objetivo reunir informações sobre as características gerais e morfológicas, patologias, aspectos clínicos e principais espécies patogênicas das infecções causadas por esse gênero. Palavras-chave: Feo-hifomicoses, Fungos dematiáceos, Micoses oportunistas. Cladosporium spp: Morphology, infections and pathogenic species AbstractThe genus Cladosporium spp comprises a large number of dematiaceous fungi with a world-wide distribution and are among the most common air-borne fungi. They are frequently isolated contaminants and some species are pathogenic and toxigenic to humans and are associated with superficial infections of the skin and soft tissues, including disseminated sepsis with high mortality. In addition, Cladoporium spp. are aero-allergens and cause serious allergic diseases of the respiratory tract, as well as intrabronchial lesions. Currently, the Cladosporium spp species of medical interest associated with human disease are C. cladosporioides, C. herbarum, C. oxysporum and C. sphaerospermum. In the case of Cladosporium spp infections, the therapy is prolonged and varies according to the clinical syndrome. Knowledge about this genre is essential for better diagnosis and appropriate treatment. This literature review to gather information about the general and morphological characteristics, pathologies, clinical aspects and main pathogenic species of the infections caused by this genus.

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“…Several recent studies have also identified the presence of emphysema on CT imaging in never-smoker patients with rheumatoid arthritis-related ILD (RA-ILD) [ 8 , 9 ], scleroderma-related ILD [ 10 ] and IPF [11 ]. Reports also suggest that emphysema occurs in never-smoker patients with HP [ [12] , [13] , [14] ]. Our study therefore aimed to characterize the prevalence and functional and prognostic effects of emphysema and PPFE identified on CT imaging in a large population of patients with hypersensitivity pneumonitis.…”

Section: Introductionmentioning

confidence: 99%

Functional associations of pleuroparenchymal fibroelastosis and emphysema with hypersensitivity pneumonitis

Jacob

Odink

Brun

et al. 2018

Respiratory Medicine

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BACKGROUNDPleuroparenchymal fibroelastosis (PPFE) has been described in hypersensitivity pneumonitis (HP) yet its functional implications are unclear. Combined pulmonary fibrosis and emphysema (CPFE) has occasionally been described in never-smokers with HP, but epidemiological data regarding its prevalence is sparse. CTs in a large HP cohort were therefore examined to identify the prevalence and effects of PPFE and emphysema.Methods233 HP patients had CT extents of interstitial lung disease (ILD) and emphysema quantified to the nearest 5%. Lobar percentage pleural involvement of PPFE was quantified on a 4-point categorical scale: 0 = absent, 1 = affecting <10%, 2 = affecting 10–33%, 3 = affecting >33%. Marked PPFE reflected a total lung score of ≥3/18. Results were evaluated against FVC, DLco and mortality.RESULTSMarked PPFE prevalence was 23% whilst 23% of never-smokers had emphysema. Following adjustment for patient age, gender, smoking status, and ILD and emphysema extents, marked PPFE independently linked to reduced baseline FVC (p = 0.0002) and DLco (p = 0.002) and when examined alongside the same covariates, independently linked to worsened survival (p = 0.01).CPFE in HP demonstrated a characteristic functional profile of artificial lung volume preservation and disproportionate DLco reduction. CPFE did not demonstrate a worsened outcome when compared to HP patients without emphysema beyond that explained by CT extents of ILD and emphysema.CONCLUSIONSPPFE is not uncommon in HP, and is independently associated with impaired lung function and increased mortality. Emphysema was identified in 23% of HP never-smokers. CPFE appears not to link to a malignant microvascular phenotype as outcome is explained by ILD and emphysema extents.

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Combined pulmonary fibrosis and emphysema in hypersensitivity pneumonitis

Cited by 18 publications

References 10 publications

The correlation between pulmonary fibrosis and methylation of peripheral Smad3 in cases of pigeon breeder’s lung in a Chinese Uygur population

The correlation between pulmonary fibrosis and methylation of peripheral Smad3 in cases of pigeon breeder’s lung in a Chinese Uygur population

Cladosporium spp: Morfologia, infecções e espécies patogênicas

Functional associations of pleuroparenchymal fibroelastosis and emphysema with hypersensitivity pneumonitis

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