Combined Preparation of Human Olfactory Ensheathing Cells in the Therapy of Post-Traumatic Cysts of the Spinal Cord

Воронова, А Д; Степанова, О. В.; Valikhov, Marat P.; Чадин, А. В.; Semkina, Alevtina S.; Karsuntseva, E. K.; Fursa, G. A.; Reshetov, Igor V.; Чехонин, В. П.

doi:10.1007/s10517-020-04925-3

Cited by 3 publications

(2 citation statements)

References 21 publications

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“…Moreover, the combination transplantation of NSCs and human olfactory ensheathing mucosa cells has shown effectiveness in preclinical trials to treat post-traumatic cysts of spinal cord injuries. This co-transplantation improved the hind limbs' motor activity and led to a cyst size reduction of 4-12% in rats [46]. Some of the advantages and limitations of different types of stem cells are summarized in Table 1.…”

Section: Neural Stem Cells (Nscs)mentioning

confidence: 95%

Spinal Cord Injury Management through the Combination of Stem Cells and Implantable 3D Bioprinted Platforms

Zarepour

Hooshmand

Gökmen

et al. 2021

Cells

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Spinal cord injury (SCI) has a major impact on affected patients due to its pathological consequences and absence of capacity for self-repair. Currently available therapies are unable to restore lost neural functions. Thus, there is a pressing need to develop novel treatments that will promote functional repair after SCI. Several experimental approaches have been explored to tackle SCI, including the combination of stem cells and 3D bioprinting. Implanted multipotent stem cells with self-renewing capacity and the ability to differentiate to a diversity of cell types are promising candidates for replacing dead cells in injured sites and restoring disrupted neural circuits. However, implanted stem cells need protection from the inflammatory agents in the injured area and support to guide them to appropriate differentiation. Not only are 3D bioprinted scaffolds able to protect stem cells, but they can also promote their differentiation and functional integration at the site of injury. In this review, we showcase some recent advances in the use of stem cells for the treatment of SCI, different types of 3D bioprinting methods, and the combined application of stem cells and 3D bioprinting technique for effective repair of SCI.

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Section: Neural Stem Cells (Nscs)mentioning

confidence: 95%

Spinal Cord Injury Management through the Combination of Stem Cells and Implantable 3D Bioprinted Platforms

Zarepour

Hooshmand

Gökmen

et al. 2021

Cells

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“…The efficacy of somatic cell reprogramming treatment strategies in human clinical trials could be limited due to the lack of control groups, and improvements in function observed in the trials could be related to decompression surgery at the time of cell transplantation or natural recovery after SCI rather than therapeutic effects ( Bartlett et al, 2020 ). Future studies are needed to confirm the efficacy of somatic cell reprogramming in human clinical trials to promote its clinical application for SCI repair ( Voronova et al, 2020b ). Moreover, the severity of SCI is determined by multiple factors that must be considered when determining the appropriate treatment.…”

Section: Challenges and Controversiesmentioning

confidence: 99%

Application and prospects of somatic cell reprogramming technology for spinal cord injury treatment

Yang

Pan

Wang

et al. 2022

Front. Cell. Neurosci.

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Spinal cord injury (SCI) is a serious neurological trauma that is challenging to treat. After SCI, many neurons in the injured area die due to necrosis or apoptosis, and astrocytes, oligodendrocytes, microglia and other non-neuronal cells become dysfunctional, hindering the repair of the injured spinal cord. Corrective surgery and biological, physical and pharmacological therapies are commonly used treatment modalities for SCI; however, no current therapeutic strategies can achieve complete recovery. Somatic cell reprogramming is a promising technology that has gradually become a feasible therapeutic approach for repairing the injured spinal cord. This revolutionary technology can reprogram fibroblasts, astrocytes, NG2 cells and neural progenitor cells into neurons or oligodendrocytes for spinal cord repair. In this review, we provide an overview of the transcription factors, genes, microRNAs (miRNAs), small molecules and combinations of these factors that can mediate somatic cell reprogramming to repair the injured spinal cord. Although many challenges and questions related to this technique remain, we believe that the beneficial effect of somatic cell reprogramming provides new ideas for achieving functional recovery after SCI and a direction for the development of treatments for SCI.

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Detection of Circulating Tumor Cells and Epithelial Progenitor Cells: A Comprehensive Study

Fuloria

Subramaniyan

Gupta

et al. 2023

J Environ Pathol Toxicol Oncol

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Technological advancement to enhance tumor cells (TC) has allowed discovery of various cellular bio-markers: cancer stem cells (CSC), circulating tumor cells (CTC), and endothelial progenitor cells (EPC). These are responsible for resistance, metastasis, and premetastatic conditions of cancer. Detection of CSC, CTC, and EPC assists in early diagnosis, recurrence prediction, and treatment efficacy. This review describes various methods to detect TC subpopulations such as <i>in vivo</i> assays (sphere-forming, serial dilution, and serial transplantation), <i>in vitro</i> assays (colony-forming cells, microsphere, side-population, surface antigen staining, aldehyde dehydrogenase activity, and Paul Karl Horan label-retaining cells, surface markers, nonenriched and enriched detection), reporter systems, and other analytical methods (flow cytometry, fluorescence microscopy/spectroscopy, etc.). The detailed information on methods to detect CSC, CTC, and EPC in this review will assist investigators in successful prognosis, diagnosis, and cancer treatment with greater ease.

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Combined Preparation of Human Olfactory Ensheathing Cells in the Therapy of Post-Traumatic Cysts of the Spinal Cord

Cited by 3 publications

References 21 publications

Spinal Cord Injury Management through the Combination of Stem Cells and Implantable 3D Bioprinted Platforms

Spinal Cord Injury Management through the Combination of Stem Cells and Implantable 3D Bioprinted Platforms

Application and prospects of somatic cell reprogramming technology for spinal cord injury treatment

Detection of Circulating Tumor Cells and Epithelial Progenitor Cells: A Comprehensive Study

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