Combined photodynamic therapy with chloroaluminum phthalocyanine and doxorubicin nanoemulsions in breast cancer model

Cabral, Ágata Silva; Leonel, Ellen Cristina Rivas; Cândido, Natália Maria; Piva, Henrique Luís; Melo, Maryanne Trafani de; Taboga, Sebastião Roberto; Rahal, Paula; Tedesco, Antônio Cláudio; Calmon, Marília Freitas

doi:10.1016/j.jphotobiol.2021.112181

Cited by 20 publications

(5 citation statements)

References 35 publications

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“…They observed that the combined regimen in the presence of laser radiation markedly inhibited the growth of 4T1-stimulated BC in mice. These findings demonstrate the effectiveness of this therapy, which could potentially replace the presently used anti-cancer techniques [ 75 ]. In another experiment, Kim and coworkers proposed aptamer-conjugated lipid nanovehicles entrapping quantum dots (QDs) and siRNA for TNBC management.…”

Section: Introductionmentioning

confidence: 81%

Nano-Based Theranostic Platforms for Breast Cancer: A Review of Latest Advancements

et al. 2022

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Breast cancer (BC) is a highly metastatic multifactorial disease with various histological and molecular subtypes. Due to recent advancements, the mortality rate in BC has improved over the past five decades. Detection and treatment of many cancers are now possible due to the application of nanomedicine in clinical practice. Nanomedicine products such as Doxil® and Abraxane® have already been extensively used for BC adjuvant therapy with favorable clinical outcomes. However, these products were designed initially for generic anticancer purposes and not specifically for BC treatment. With a better understanding of the molecular biology of BC, several novel and promising nanotherapeutic strategies and devices have been developed in recent years. In this context, multi-functionalized nanostructures are becoming potential carriers for enhanced chemotherapy in BC patients. To design these nanostructures, a wide range of materials, such as proteins, lipids, polymers, and hybrid materials, can be used and tailored for specific purposes against BC. Selective targeting of BC cells results in the activation of programmed cell death in BC cells and can be considered a promising strategy for managing triple-negative BC. Currently, conventional BC screening methods such as mammography, digital breast tomosynthesis (DBT), ultrasonography, and magnetic resonance imaging (MRI) are either costly or expose the user to hazardous radiation that could harm them. Therefore, there is a need for such analytical techniques for detecting BC that are highly selective and sensitive, have a very low detection limit, are durable, biocompatible, and reproducible. In detecting BC biomarkers, nanostructures are used alone or in conjunction with numerous molecules. This review intends to highlight the recent advances in nanomedicine in BC treatment and diagnosis, emphasizing the targeting of BC cells that overexpress receptors of epidermal growth factors. Researchers may gain insight from these strategies to design and develop more tailored nanomedicine for BC to achieve further improvements in cancer specificity, antitumorigenic effects, anti-metastasis effects, and drug resistance reversal effects.

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Section: Introductionmentioning

confidence: 81%

Nano-Based Theranostic Platforms for Breast Cancer: A Review of Latest Advancements

et al. 2022

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“…This presents a synergistic approach for future trials in aPDT. Photodynamic therapy (PDT) has been recently demonstrated to be a powerful strategy for tumor destruction, and nanotechnology is also suggested to reduce treatment dosage and frequency by enabling the delivery of drugs within confined tissues using nanoemulsions [ 55 ]. Several innovative alternatives, such as ultrasonic irrigation, laser wavelengths, and photodynamic therapy, have been used for the treatment of oral infections caused by microorganisms that reside within the root canal system [ 47 ].…”

Section: Discussionmentioning

confidence: 99%

Antimicrobial Photodynamic Therapy against Escherichia coli and Staphylococcus aureus Using Nanoemulsion-Encapsulated Zinc Phthalocyanine

et al. 2023

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Multidrug-resistant microorganisms have become a significant public health threat, and traditional antibiotics are becoming ineffective. Photodynamic therapy (PDT) is a promising alternative that utilizes photosensitizers and light to produce Reactive Oxygen Species (ROS) that can kill microorganisms. Zinc phthalocyanine (ZnPc) is a promising photosensitizer due to its strong affinity for encapsulation in nanoemulsions and its antimicrobial properties. In this study, nanoemulsion was prepared using Miglyol 812N, a surfactant, and distilled water to dissolve hydrophobic drugs such as ZnPc. The nanoemulsion was characterized by its particle size, polydispersity index, Transmission Electron Microscope and Zeta potential, and the results showed that it was an efficient nanocarrier system that facilitated the solubilization of hydrophobic drugs in water. The use of ZnPc encapsulated in the nanoemulsion produced through the spontaneous emulsification method resulted in a significant reduction in cell survival percentages of gram-positive Staphylococcus aureus and gram-negative Escherichia coli by 85% and 75%, respectively. This may be attributed to the more complex cell membrane structure of E. coli compared to S. aureus. This demonstrates the potential of nanoemulsion-based PDT as an effective alternative to traditional antibiotics for treating multidrug-resistant microorganisms.

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“…Therefore, the combination of DOX-based chemotherapy with other anticancer modalities may relieve collateral effects by lowering doses, while preserving treatment efficacy. Indeed, the combination of DOX with PDT has been widely investigated, using various types of nanosized carriers, designed to fully exploit the potential additive/synergistic effects of this combined regimen [ 116 , 117 , 118 ], offering a way to address the limitations described above.…”

Section: Drug Delivery Systems For Pss and Chemotherapeutics: An Over...mentioning

confidence: 99%

Overview of Nanoparticle-Based Approaches for the Combination of Photodynamic Therapy (PDT) and Chemotherapy at the Preclinical Stage

Menilli

Milani

Reddi

et al. 2022

Cancers

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The widespread diffusion of photodynamic therapy (PDT) as a clinical treatment for solid tumors is mainly limited by the patient’s adverse reaction (skin photosensivity), insufficient light penetration in deeply seated neoplastic lesions, unfavorable photosensitizers (PSs) biodistribution, and photokilling efficiency due to PS aggregation in biological environments. Despite this, recent preclinical studies reported on successful combinatorial regimes of PSs with chemotherapeutics obtained through the drugs encapsulation in multifunctional nanometric delivery systems. The aim of the present review deals with the punctual description of several nanosystems designed not only with the objective of co-transporting a PS and a chemodrug for combination therapy, but also with the goal of improving the therapeutic efficacy by facing the main critical issues of both therapies (side effects, scarce tumor oxygenation and light penetration, premature drug clearance, unspecific biodistribution, etc.). Therefore, particular attention is paid to the description of bio-responsive drugs and nanoparticles (NPs), targeted nanosystems, biomimetic approaches, and upconverting NPs, including analyzing the therapeutic efficacy of the proposed photo-chemotherapeutic regimens in in vitro and in vivo cancer models.

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Combined photodynamic therapy with chloroaluminum phthalocyanine and doxorubicin nanoemulsions in breast cancer model

Cited by 20 publications

References 35 publications

Nano-Based Theranostic Platforms for Breast Cancer: A Review of Latest Advancements

Nano-Based Theranostic Platforms for Breast Cancer: A Review of Latest Advancements

Antimicrobial Photodynamic Therapy against Escherichia coli and Staphylococcus aureus Using Nanoemulsion-Encapsulated Zinc Phthalocyanine

Overview of Nanoparticle-Based Approaches for the Combination of Photodynamic Therapy (PDT) and Chemotherapy at the Preclinical Stage

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