Combined Photodynamic and Radiotherapy Synergistic Effect in Cancer Treatment

Yurt, Fatma; Tunçel, Ayça

doi:10.31031/nacs.2018.01.000506

Cited by 5 publications

(1 citation statement)

References 45 publications

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“…A recent review article of Yurt & Tuncel [1] reported the clinical aspects of combined photodynamic and radiotherapy synergistic effect in cancer treatment. Synergic method combining photothermal therapy (PTT) and photodynamic therapy (PDT) using nanogold particles and photosensitizers were also reported [2][3][4].…”

Section: Introductionmentioning

confidence: 99%

Advances of Cancer Synergic Photo-Therapy: Kinetics and Efficacy

Lin¹

2018

NACS

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The kinetics and efficacy of anti-cancer via phototherapy are reviewed. Factors influencing the cancer therapy efficiency in both photothermal therapy (PTT) and photodynamic therapy (PDT) using nanogold particles and photosensitizers (PS), respectively, are analyzed. Efficacy of cancer therapy may be enhanced by combining PTT and PDT either activated by one light or two lights. For maximum PTT/PDT synergistic efficacy, the concentration of photosensitizers and nanogold required optimization, besides the wavelength of the light matching the absorption peak of PS and nanogold, and the sequential order of PTT and PDT process. External supply of either photosensitizers or oxygen concentration will significantly improve the anti-cancer efficacy via type-II PDT. The singlet oxygen threshold dose for PDT and cell viability are governed by the product of PS concentration and light dose.

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Section: Introductionmentioning

confidence: 99%

Advances of Cancer Synergic Photo-Therapy: Kinetics and Efficacy

Lin¹

2018

NACS

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The Cellular Response to Exposure to Ionizing Radiation and Light in the Presence of a Photosensitizer

Akulinichev,

Glukhov,

Efremenko

et al. 2023

BIOPHYSICS

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Utilization of nanotechnology in targeted radionuclide cancer therapy: monotherapy, combined therapy and radiosensitization

Bayoumi

El-Kolaly

2021

Radiochimica Acta

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The rapid progress of nanomedicine field has a great influence on the different tumor therapeutic trends. It achieves a potential targeting of the therapeutic agent to the tumor site with neglectable exposure of the normal tissue. In nuclear medicine, nanocarriers have been employed for targeted delivery of therapeutic radioisotopes to the malignant tissues. This systemic radiotherapy is employed to overcome the external radiation therapy drawbacks. This review overviews studies concerned with investigation of different nanoparticles as promising carriers for targeted radiotherapy. It discusses the employment of different nanovehicles for achievement of the synergistic effect of targeted radiotherapy with other tumor therapeutic modalities such as hyperthermia and photodynamic therapy. Radiosensitization utilizing different nanosensitizer loaded nanoparticles has also been discussed briefly as one of the nanomedicine approach in radiotherapy.

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Combined Photodynamic and Radiotherapy Synergistic Effect in Cancer Treatment

Abstract: This review aims to increase the success rate in the treatment of cancer when both photodynamic therapy and radiotherapy are used together as a combined therapy and it is aimed to inform this direction.

Cited by 5 publications

References 45 publications

Advances of Cancer Synergic Photo-Therapy: Kinetics and Efficacy

Advances of Cancer Synergic Photo-Therapy: Kinetics and Efficacy

The Cellular Response to Exposure to Ionizing Radiation and Light in the Presence of a Photosensitizer

Utilization of nanotechnology in targeted radionuclide cancer therapy: monotherapy, combined therapy and radiosensitization

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