Combined phenylephrine and tranylcypromine for postural hypotension

Itskovitz, Harold D.; Wartenburg, Alan

doi:10.1016/0002-8703(83)90712-3

Cited by 4 publications

(1 citation statement)

References 5 publications

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“…Phenylephrine and midodrine (2.5-5 mg 3 times daily) have value in some patients with autonomic insufficiency , but are generally disappointing in that, when used in doses high enough to reduce orthostatic hypotension, they tend to cause recumbent hypertension (Davies et aI., 1978). Itskovitz and Wartenburg (1983) reported a good response to phenylephrine (10-15 mg every 4-6 hr) together with tranylcypromine (10 mg twice daily) in a patient with autonomic failure whose condition was not improved by fludrocortisone, indomethacin, or elastic stockings. Hickler et al (1959b) found in a patient with autonomic failure that the blood pressure could be maintained in the upright posture by an intravenous infusion of norepinephrine.…”

Section: A 1 -Adrenergic Agonistsmentioning

confidence: 99%

Orthostatic Disorders of the Circulation

Streeten

1987

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Section: A 1 -Adrenergic Agonistsmentioning

confidence: 99%

Orthostatic Disorders of the Circulation

Streeten

1987

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Beneficial Effects of Dextro‐Amphetamine in the Treatment of Vasodepressor Syncope

Susmano

Volgman

Buckingham

1993

Pacing Clinical Electrophis

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Three patients with history of documented hypotension, near syncope, or syncope before or after the administration of isoproterenol during head-up tilt table are reported. Severe bradycardia was also noted in one patient. All three patients responded to the administration of 2.5 mg of oral dextroamphetamine 45 minutes prior to a repeat head-up tilt table study. The potent central and peripheral adrenergic agonist pharmacological properties of this drug permitted the prevention of severe vasodepressor syncope in these patients.

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Orthostatic Hypotension: Therapeutic Alternatives for Geriatric Patients

Davis¹,

Delafuente²

1989

DICP

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Symptomatic orthostatic hypotension is a serious problem in the elderly because it can precipitate falls and fractures, myocardial infarctions, and strokes. Several disorders may cause symptomatic orthostatic hypotension including age-related changes in physiology, disorders of the autonomic nervous system, drugs, and a decrease in circulating blood volume. Orthostatic hypotension is defined as a fall in systolic pressure of at least 20–30 mm Hg and a fall in diastolic pressure of at least 10–15 mm Hg upon rising, with symptoms of cerebral ischemia. Management includes a search for reversible causes as well as nonpharmacologic and pharmacologic therapies. No single agent has been universally successful in relieving the symptoms of orthostatic hypotension. Trials of single agents or combinations of agents are needed to identify the most appropriate therapy for individual patients.

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Combined phenylephrine and tranylcypromine for postural hypotension

Cited by 4 publications

References 5 publications

Orthostatic Disorders of the Circulation

Orthostatic Disorders of the Circulation

Beneficial Effects of Dextro‐Amphetamine in the Treatment of Vasodepressor Syncope

Orthostatic Hypotension: Therapeutic Alternatives for Geriatric Patients

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