Combined PET/CT-perfusion in patients with head and neck cancers might predict failure after radio-chemotherapy: a proof of concept study

Abstract

Background[18F]FDG-PET/CT imaging is broadly used in head and neck cancer (HNSCC) patients. CT perfusion (CTP) is known to provide information about angiogenesis and blood-flow characteristics in tumors. The aim of this study was to evaluate the potential relationship of FDG-parameters and CTP-parameters in HNSCC preand post-therapy and the potential prognostic value of a combined PET/CT with CTP.MethodsThirteen patients with histologic proven HNSCC were prospectively included. All patients underwent a combined PET/CT with integrated CTP before and after therapy. Pre- and post-therapeutic data of CTP and PET of the tumors were compared. Differences were tested using Spearman’s rho test and Pearson’s correlation. A p-value of p <0.05 was considered statistically significant. Correlations were calculated using Pearson’s correlation. Bootstrap confidence intervals were calculated to test for additive confidence intervals.ResultsThree patients died due to malignancy recurrence, ten patients were free of recurrence until the end of the follow-up period. Patients with recurrent disease had significantly higher initial CTP-values compared to the recurrence-free patients: BFpre 267.4 (171.2)ml/100 mg/min, BVpre 40.9 (8.4)ml/100 mg and MTTpre 8.2 (6.1)sec. No higher SUVs initially but significantly higher TLG compared to patients without recurrence were found. Post-therapeutic PET-values differed significantly between the two groups: SUVmaxpost 6.0 (3.2), SUVmeanpost 3.6 (2.0) and TLG 21751.7 (29794.0).ConclusionIn our proof of concept study, combined PET/CT with integrated CTP might show complementary prognostic data pre- and post chemo-radiotherapy. CTP may be used to predict local tumor recurrence, while FDGPET/CT is still needed for whole-body staging.

Prognostic role of diffusion weighted and dynamic contrast-enhanced MRI in loco-regionally advanced head and neck cancer treated with concomitant chemoradiotherapy

“…Multi-parametric imaging with functional imaging techniques has recently been used to evaluate biological properties of malignant tumours as changes at a cellular level typically occur prior to morphological changes. CT perfusion (CTP) has already been reported to provide a valuable information on tumour vascularity 8, 9, 10. In recent years, diffusion-weighted (DW) MR imaging (MRI) and dynamic contrast-enhanced MRI (DCE) have been used for assessing tumour biology and to predict tumour response and survival rates in patients with HNSCC.…”

“…CT perfusion (CTP) has already been reported to provide a valuable information on tumour vascularity. 8 , 9 , 10 In recent years, diffusion-weighted (DW) MR imaging (MRI) and dynamic contrast-enhanced MRI (DCE) have been used for assessing tumour biology and to predict tumour response and survival rates in patients with HNSCC. DWI is a widely used technique that allows for non-invasive measurement of the Brownian motion of water molecules by calculating the apparent diffusion coefficient (ADC) which reflects tumour cellularity and tissue microstructure.…”

Dynamic contrast-enhanced computed tomography in 11 dogs with orofacial tumors

“…Results of similar studies in human patients with head and neck cancer are inconsistent, yet most studies have found that high pre-treatment BF and BV were associated with a better response to treatment, locoregional control, or survival. 20,[33][34][35][36][37][38] This could be explained by the fact that well vascularized and well oxygenated tumors are generally better responders to RT. 39 In the current study, 3 out of 4 dogs who showed a reduction in size of the tumor during RT also showed an increased in BF and BV at 12 Gy.…”