Combined oral contraceptives’ influence on weight, body composition, height, and bone mineral density in girls younger than 18 years: A systematic review

Warholm, Lina; Petersen, Kathrine Birch; Ravn, Pernille

doi:10.3109/13625187.2012.692411

Cited by 28 publications

(9 citation statements)

References 34 publications

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“…Even though weight gain is often attributed as a side effect of contraceptive use [51], there is no scientific evidence to indicate that oral contraceptives induce weight gain [52]. Our observation may be due to contraceptive users adopting “obesity-preventive” lifestyle/dietary habits because of the belief that contraceptive use may result in EBW.…”

Section: Discussionmentioning

confidence: 70%

A Lower Degree of PBMC L1 Methylation Is Associated with Excess Body Weight and Higher HOMA-IR in the Presence of Lower Concentrations of Plasma Folate

et al. 2013

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BackgroundIdentification of associations between global DNA methylation and excess body weight (EBW) and related diseases and their modifying factors are an unmet research need that may lead to decreasing DNA methylation-associated disease risks in humans. The purpose of the current study was to evaluate the following; 1) Association between the degree of peripheral blood mononuclear cell (PBMC) L1 methylation and folate, and indicators of EBW, 2) Association between the degree of PBMC L1 methylation and folate, and insulin resistance (IR) as indicated by a higher homeostasis model assessment (HOMA-IR).MethodsThe study population consisted of 470 child-bearing age women diagnosed with abnormal pap. The degree of PBMC L1 methylation was assessed by pyrosequencing. Logistic regression models specified indicators of EBW (body mass index–BMI, body fat–BF and waist circumference–WC) or HOMA-IR as dependent variables and the degree of PBMC L1 methylation and circulating concentrations of folate as the independent predictor of primary interest.ResultsWomen with a lower degree of PBMC L1 methylation and lower plasma folate concentrations were significantly more likely to have higher BMI, % BF or WC (OR = 2.49, 95% CI:1.41–4.47, P = 0.002; OR = 2.49, 95% CI:1.40–4.51, P = 0.002 and OR = 1.98, 95% = 1.14–3.48 P = 0.0145, respectively) and higher HOMA-IR (OR = 1.78, 95% CI:1.02–3.13, P = 0.041).ConclusionOur results demonstrated that a lower degree of PBMC L1 methylation is associated with excess body weight and higher HOMA-IR, especially in the presence of lower concentrations of plasma folate.

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Section: Discussionmentioning

confidence: 70%

A Lower Degree of PBMC L1 Methylation Is Associated with Excess Body Weight and Higher HOMA-IR in the Presence of Lower Concentrations of Plasma Folate

et al. 2013

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“…Similarly, a systematic review covering published studies from 1990 to 2012 on patients younger than 18 years old did not show any correlation between combination contraceptives and weight gain or changes in body composition [133]. Various combinations of oral contraceptives studied in 150 women, both obese and normal weight, were not associated with any significant weight gain, changes in body composition, or increases in BMI over 3-4 months [134].…”

Section: Oral Contraceptivesmentioning

confidence: 96%

Common Medications Which Lead to Unintended Alterations in Weight Gain or Organ Lipotoxicity

Medici

McClave

Miller

2015

Curr Gastroenterol Rep

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Obesity is one of the most common chronic conditions in the world. Its management is difficult, partly due to the multiple associated comorbidities including fatty liver, diabetes, hypertension, and hyperlipidemia. As a result, the choice of prescription medications in overweight and obese patients has important implications as some of them can actually worsen the fat accumulation and its associated metabolic complications. Several prescription medications are associated with weight gain with mechanisms that are often poorly understood and under-recognized. Even less data are available on the distribution of fat and lipotoxicity (the organ damage related to fat accumulation). The present review will discuss the drugs associated with weight gain, their mechanism of action, and the magnitude and timing of their effect.

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“…The limited evidence does not support a causal association between use of CHC and weight gain, and there is no consistent evidence that different CHC formulations affect weight differently. A systematic review175 which identified data for women aged under 18 years from nine observational trials, concluded that there is no evidence of an association between CHC use and weight gain in this group of women.…”

Section: Side Effects Associated With Chc Usementioning

confidence: 99%

FSRH Guideline (January 2019, amended October 2023) Combined Hormonal Contraception

2019

BMJ Sex Reprod Health

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Combined oral contraceptives’ influence on weight, body composition, height, and bone mineral density in girls younger than 18 years: A systematic review

Cited by 28 publications

References 34 publications

A Lower Degree of PBMC L1 Methylation Is Associated with Excess Body Weight and Higher HOMA-IR in the Presence of Lower Concentrations of Plasma Folate

A Lower Degree of PBMC L1 Methylation Is Associated with Excess Body Weight and Higher HOMA-IR in the Presence of Lower Concentrations of Plasma Folate

Common Medications Which Lead to Unintended Alterations in Weight Gain or Organ Lipotoxicity

FSRH Guideline (January 2019, amended October 2023) Combined Hormonal Contraception

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