Combined Oral Contraceptive Pills Containing Desogestrel or Drospirenone Enhance Large Vessel and Microvasculature Vasodilation in Healthy Premenopausal Women

Thompson, Abby K.; Przemska, A.; Vasilopoulou, Dafni; Newens, K. J.; Williams, Christine M.

doi:10.1111/j.1549-8719.2011.00094.x

Cited by 23 publications

(21 citation statements)

References 50 publications

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“…As there is evidence that smoking, and mixed evidence that contraceptives, have an effect on endothelial function, cholesterol and blood pressure, their influence on the results of the current study were examined (Celermajer et al, 1993;Franceschini et al, 2013;Heidarzadeh et al, 2014;Ozaki et al, 2010;Thompson et al, 2011;Toda and Toda, 2010;Virdis et al, 2003). The results remained unchanged when either smoking or contraceptive use were included as covariates.…”

Section: Cardiovascular Factorsmentioning

confidence: 83%

Early physiological markers of cardiovascular risk in community based adolescents with a depressive disorder

Waloszek¹,

Byrne²,

Woods³

et al. 2015

Journal of Affective Disorders

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Section: Cardiovascular Factorsmentioning

confidence: 83%

Early physiological markers of cardiovascular risk in community based adolescents with a depressive disorder

Waloszek¹,

Byrne²,

Woods³

et al. 2015

Journal of Affective Disorders

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“…In contrast to the negative impact of hyperglycaemia, oestrogen has well‐established protective effects on endothelial function. For example, elevated synthetic oestrogen levels can improve FMD in postmenopausal women on oestrogen hormone replacement therapy (Hashimoto et al., ; Lieberman et al., ; Sherwood et al., ), and in premenopausal women on oral contraceptive pills (Meendering, Torgrimson, Miller, Kaplan, & Minson, ; Thompson, Przemska, Vasilopoulou, Newens, & Williams, ). Likewise, it has often been shown that FMD is augmented during the late follicular (LF) phase of the natural menstrual cycle, when oestrogen (estradiol) levels are elevated (Adkisson et al., ; Harris, Tedjasaputra, Zhao, & Richardson, ; Hashimoto et al., ; Kawano et al., ).…”

Section: Introductionmentioning

confidence: 99%

The influence of acute hyperglycaemia on brachial artery flow‐mediated dilatation in the early and late follicular phases of the menstrual cycle

Williams

Stimpson

Tremblay

et al. 2019

Experimental Physiology

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New Findings What is the central question of the study?This is the first study to examine the impact of acute hyperglycaemia on endothelial function [flow‐mediated dilatation (FMD)] in premenopausal women across the early and late follicular (EF and LF) phases of the menstrual cycle. What is the main finding and its importance?Flow‐mediated dilatation was impaired 90 min after glucose ingestion, with no significant difference between phases. This indicates that women are susceptible to acute hyperglycaemia‐induced endothelial dysfunction in both the EF and LF phases of the menstrual cycle, despite potentially vasoprotective elevations in estradiol levels during the LF phase. Abstract Acute hyperglycaemia transiently impairs endothelial function in healthy men when assessed via flow‐mediated dilatation (FMD). However, research in female participants is lacking, and the impact of menstrual phase [early follicular (EF) and late follicular (LF)] on vulnerability to acute hyperglycaemia‐induced endothelial dysfunction is unknown. Seventeen healthy, naturally menstruating women [21 ± 1 years old (mean ± SD)] participated in three visits. During two visits (EFGlucose and LFGlucose), brachial artery FMD was assessed before and 60, 90 and 120 min after an oral glucose challenge (75 g glucose). During an additional EF visit, participants ingested 300 ml of water (EFTimeControl). Blood glucose and insulin increased 30 min after glucose ingestion (P < 0.001), with no difference between phases. Flow‐mediated dilatation did not change in EFTimeControl (P = 0.748) but was reduced 90 min after glucose ingestion (Pre, 8.5 ± 2.5%; Post90, 6.6 ± 2.4%, P = 0.001; Cohen's d = 0.82), with no difference between phases (main effect of phase, P = 0.506; phase by time interaction, P = 0.391). To account for individual variability in the time course of the impact of hyperglycaemia, the maximal hyperglycaemia‐induced impairment in FMD was determined in each participant and compared between phases, revealing no significant phase differences (EFGlucose, −3.1 ± 2.8%; LFGlucose, −2.4 ± 2.1%, P = 0.181; d = 0.34). These results indicate that, similar to findings in men, acute hyperglycaemia results in FMD impairment in young women. We did not detect significant protection from acute hyperglycaemia‐induced endothelial dysfunction in the LF ‘high‐oestrogen’ phase in this sample, and further research is needed to examine the potential for a protective effect of oestrogen exposure, including oral contraceptive pills and hormone replacement therapy.

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“…FMD of the brachial artery was measured by trained researchers using an ATL Ultrasound HDI5000 broadband ultrasound system (ATL Ultrasound, Bothell, Washington) and a procedure based on standard guidelines, as previously described [16] . Briefly, following baseline imaging, a blood pressure cuff was inflated to 220 mm Hg to occlude blood flow for 5 min.…”

Section: Methodsmentioning

confidence: 99%

Endothelial function and insulin sensitivity during acute non-esterified fatty acid elevation: Effects of fat composition and gender

Newens¹,

Thompson²,

Jackson³

et al. 2015

Nutrition, Metabolism and Cardiovascular Diseases

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Background and aimsWe have reported that adverse effects on flow-mediated dilation of an acute elevation of non-esterified fatty acids rich in saturated fat (SFA) are reversed following addition of long-chain (LC) n-3 polyunsaturated fatty acids (PUFA), and hypothesised that these effects may be mediated through alterations in insulin signalling pathways. In a subgroup, we explored the effects of raised NEFA enriched with SFA, with or without LC n-3 PUFA, on whole body insulin sensitivity (SI) and responsiveness of the endothelium to insulin infusion.Methods and resultsThirty adults (mean age 27.8 y, BMI 23.2 kg/m2) consumed oral fat loads on separate occasions with continuous heparin infusion to elevate NEFA between 60 and 390 min. For the final 150 min, a hyperinsulinaemic-euglycaemic clamp was performed, whilst FMD and circulating markers of endothelial function were measured at baseline, pre-clamp (240 min) and post-clamp (390 min). NEFA elevation during the SFA-rich drinks was associated with impaired FMD (P = 0.027) whilst SFA + LC n-3 PUFA improved FMD at 240 min (P = 0.003). In males, insulin infusion attenuated the increase in FMD with SFA + LC n-3 PUFA (P = 0.049), with SI 10% greater with SFA + LC n-3 PUFA than SFA (P = 0.041).ConclusionThis study provides evidence that NEFA composition during acute elevation influences both FMD and SI, with some indication of a difference by gender. However our findings are not consistent with the hypothesis that the effects of fatty acids on endothelial function and SI operate through a common pathway.This trial was registered at clinical trials.gov as NCT01351324 on 6th May 2011.

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Combined Oral Contraceptive Pills Containing Desogestrel or Drospirenone Enhance Large Vessel and Microvasculature Vasodilation in Healthy Premenopausal Women

Abstract: COCs containing 150 μg DSG or 3 mg DR significantly increase endothelium-dependent vasodilation in both large vessels and peripheral microvasculature. These effects may be due to the progestins exhibiting differential effects on eNOS expression.

Cited by 23 publications

References 50 publications

Early physiological markers of cardiovascular risk in community based adolescents with a depressive disorder

Early physiological markers of cardiovascular risk in community based adolescents with a depressive disorder

The influence of acute hyperglycaemia on brachial artery flow‐mediated dilatation in the early and late follicular phases of the menstrual cycle

Endothelial function and insulin sensitivity during acute non-esterified fatty acid elevation: Effects of fat composition and gender

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