Combined occurrence of prostate carcinoma and malacoplakia

Répássy, D; Iványi, A; Csata, S; Tamás, György

doi:10.1007/bf03032396

Cited by 13 publications

(5 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In about half of the cases, the differential diagnosis includes malignancy, mainly because of the presence of a hard nodule on digital rectal examination and the hypoechoic areas seen on transrectal ultrasound imaging. [85][86][87][88][89] Malakoplakia is a poorly circumscribed lesion characterized by diffuse sheets of macrophages, mostly representing epithelioid histiocytes with granular eosinophilic cytoplasm (von Hansemann histiocytes), admixed with lymphocytes, plasma cells, and neutrophils (Figures 17d and e). They contain intracytoplasmic, spherical, sharply demarcated, and often concentrically laminated, basophilic inclusions, known as Michaelis-Gutmann bodies, which represent calcified bacterial debris (Figure 17e).…”

Section: Signet-ring Lymphocytesmentioning

confidence: 99%

See 1 more Smart Citation

Benign mimics of prostatic adenocarcinoma

Trpkov

2018

Modern Pathology

View full text Add to dashboard Cite

Benign mimics present either as common challenges in daily routine practice or may cause diagnostic dilemmas because some are less commonly seen and one may be less familiar in recognizing them. There are a multitude of mimics of prostatic adenocarcinoma, which may represent normal gland structures, benign proliferations, atrophic lesions, hyperplastic or metaplastic changes, and inflammatory processes. Some of them are preferentially found in certain anatomic areas of the prostate, either confined to the prostate, or outside of the gland. Various benign mimics of prostatic carcinoma may be also evaluated based on their morphologic similarity to Gleason patterns 3-5 of prostatic adenocarcinoma. Most of the mimics are easily recognizable in larger specimens, such as TUR of the prostate or radical prostatectomy specimens, but they may pose diagnostic problems when the evaluation is done on limited tissue, such as needle-core biopsies or if prostate specimens are infrequently encountered in practice. Therefore, before signing out a report with a diagnosis of prostatic carcinoma, pathologists should carefully consider and rule out the various benign lesions that may mimic carcinoma. This is particularly relevant in the current prostate biopsy practice which relies on using extended biopsy core templates. The awareness and familiarity with the characteristic features of the mimics and judicial use of additional ancillary tests, including immunohistochemistry can prevent overdiagnosis and false-positive interpretation. This review provides a contemporary update on the broad spectrum of the benign prostatic lesions that can mimic prostate adenocarcinoma, outlines their key morphologic and immunohistochemical diagnostic features, and provides a diagnostic, pattern-based approach in establishing a correct diagnosis and distinguishing them reliably from prostatic adenocarcinoma.

show abstract

Section: Signet-ring Lymphocytesmentioning

confidence: 99%

“…Rare cases have been described in which malakoplakia and prostatic carcinoma have been simultaneously found in the prostate. [85][86][87][88][89] The finding of Michaelis-Gutmann bodies essentially excludes a diagnosis of high-grade prostatic carcinoma.…”

Section: Signet-ring Lymphocytesmentioning

confidence: 99%

Benign mimics of prostatic adenocarcinoma

Trpkov

2018

Modern Pathology

View full text Add to dashboard Cite

show abstract

“…An association between malakoplakia of the colon and colorectal adenocarcinoma has also been suggested [13][14][15][16]. Importantly, malignancy and malakoplakia can coexist in the same specimen [13][14][15][16][17]. Pathologists need to be alert to this possibility or important diseases may go undiagnosed.…”

Section: Discussionmentioning

confidence: 99%

Presacral malakoplakia presenting as foot drop: a case report

et al. 2023

View full text Add to dashboard Cite

Background Malakoplakia is a rare condition characterized by inflammatory masses with specific histological characteristics. These soft tissue masses can mimic tumors and tend to develop in association with chronic or recurrent infections, typically of the urinary tract. A specific defect in innate immunity has been described. In the absence of randomized controlled trials, management is based on an understanding of the biology and on case reports. Case presentation Here we describe a case of presacral malakoplakia in a British Indian woman in her late 30s, presenting with complex unilateral foot drop. Four years earlier, she had suffered a protracted episode of intrapelvic sepsis following a caesarean delivery. Resection of her presacral soft tissue mass was not possible. She received empiric antibiotics, a cholinergic agonist, and ascorbic acid. She responded well to medical management both when first treated and following a recurrence of symptoms after completing an initial 8 months of therapy. Whole exome sequencing of the patient and her parents was undertaken but no clear causal variant was identified. Conclusions Malakoplakia is uncommon but the diagnosis should be considered where soft tissue masses develop at the site of chronic or recurrent infections. Obtaining tissue for histological examination is key to making the diagnosis. This case suggests that surgical resection is not always needed to achieve a good clinical and radiological outcome.

show abstract

“…There are only isolated reports on malakoplakia imaging in the literature, which recognize that the imaging findings of malakoplakia often mimic different diseases and cancers. PMP is extremely rare, but imaging information on it is even rarer ( 13 , 14 ).…”

Section: Discussionmentioning

confidence: 99%

Case report: Prostatic malakoplakia: a rare disease that has a profile mimicking prostate cancer

Ren,

Chen,

Zhang

et al. 2024

Front. Oncol.

View full text Add to dashboard Cite

Prostatic malakoplakia (PMP) is a rare inflammatory disease, and misdiagnosis on imaging is a major reason for unnecessary punctures; however, information on imaging is even rarer. Five patients with PMP between May 2022 and February 2023 were enrolled in this study to summarize the imaging manifestations. All patients underwent ultrasound (US)-guided prostate biopsy and were confirmed by pathology, and the presence of prostate cancer was also excluded by pathology. The five patients, with a median age of 71 years (range = 58–74 years), had a median total prostate-specific antigen (T-PSA) of 10.40 ng/mL (range = 1.74–63.42 ng/mL). In two patients, chest computed tomography showed pulmonary infections. All patients underwent magnetic resonance imaging (MRI). Of these patients, four had a Prostate Imaging–Reporting and Data System (PIRADS) score of 5, while one had a score of 4. The lesions were mostly distributed in the peripheral zone of the prostate and appeared as a high signal on T1-weighted imaging (T1WI) and a low signal on T2-weighted imaging (T2WI). In the US examination, four patients had abnormal prostate morphology, with an unsmooth envelope and non-uniform parenchymal echogenicity. Four patients had increased prostate volume. US showed a hypoechoic nodule with non-uniform internal echogenicity, and an abundant internal blood flow signal was detected by color Doppler US. PSA, MRI, and US were not specific for PMP in our study, but we found that a history of co-infection may be helpful in an accurate diagnosis and to avoid unnecessary biopsy.

show abstract

Combined occurrence of prostate carcinoma and malacoplakia

Cited by 13 publications

References 9 publications

Benign mimics of prostatic adenocarcinoma

Benign mimics of prostatic adenocarcinoma

Presacral malakoplakia presenting as foot drop: a case report

Case report: Prostatic malakoplakia: a rare disease that has a profile mimicking prostate cancer

Contact Info

Product

Resources

About