Combined modality therapy of esthesioneuroblastoma

McLean, J. Nicolas; Nunley, Sunjay; Klass, Carmen M.; Moore, Charles E.; Müller, Susan; Johnstone, Peter A.S.

doi:10.1016/j.otohns.2006.11.051

Cited by 61 publications

(58 citation statements)

References 20 publications

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“…Given the rarity of ONB, most published series were retrospective and had a small number of patients (12)(13)(14)(15) and chemotherapy (17). In the present study, all patients had T4 ONBs; the OS and LC at 3 and 5 years were 88.4% and 70.3%, and 83.0% and 83.0%, respectively.…”

Section: Discussionmentioning

confidence: 52%

A Retrospective Multicenter Study of Carbon Ion Radiotherapy for Locally Advanced Olfactory Neuroblastomas

Suefuji

Koto

Demizu

et al. 2018

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Abstract. The purpose was to evaluate efficacy and safety of carbon ion radiotherapy (C-ion RT) in patients with locally advanced olfactory neuroblastomas (ONBs). This study was a sub-analysis of the Japan Carbon-Ion Radiation Oncology Study Group Study (1402 HN, UMIN000024473). Clinical data of T4 ONBs treated with C-ion RT at fourOlfactory neuroblastoma (ONB) of the head and neck is a rare malignant tumour that arises from the olfactory neuroepithelium in the upper nasal cavity with extension into the skull base, into the orbit and to the intracranial space (1, 2). Surgery is considered a curative treatment for localized ONB, while postoperative radiotherapy (RT) is necessary for advanced ONBs. Definitive RT alone is considered insufficient therapy for ONBs (3). In advanced cases, intracranial extension may pose a surgical challenge (4). Surgical resection followed by postoperative RT is associated with reduced local recurrence (5).Although ONB has been traditionally regarded as a radioresistant tumour, RT has widely been used as part of the treatment algorithm in adjuvant and definitive settings.Compared to photons, carbon ions (C-ions) offer a higher linear energy transfer and greater relative biological effectiveness (RBE) and therefore provide a higher probability of tumour control. The physical characteristics of C-ions, such as their Bragg peak and small lateral scattering, are theoretically superior to those of photons in that C-ions can allow a more localized delivery of the radiation dose.This study is the first report for ONBs treated by C-ion RT. C-Ion RT for various head and neck radioresistant malignancies has shown excellent results. Jingu et al. reported clinical results of 37 patients with malignant melanoma of the head and neck who received C-ion RT with concurrent chemotherapy. The 3-year local control (LC) and overall survival (OS) rates were 81.1% and 65.3%, respectively (6). Koto et al. reported 3-year LC and OS rates of 76.9% and 59.1%, respectively, in 22 patients with locally advanced sinonasal adenocarcinoma + reated with C-ion RT (7). Therefore, C-ion RT might be a useful and potentially curative option for unresectable head and neck tumours, including ONBs.In November 2003, following a clinical trial, the Ministry of Health, Labour and Welfare in Japan approved C-ion RT as a highly advanced medical technology. As of the end of 2014, there were four C-ion facilities functioning in Japan

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Section: Discussionmentioning

confidence: 52%

A Retrospective Multicenter Study of Carbon Ion Radiotherapy for Locally Advanced Olfactory Neuroblastomas

Suefuji

Koto

Demizu

et al. 2018

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“…Mclean et al found that there is no any survival benefit when cisplatin plus etoposide was added to the surgery in patients with olfactory neuroblastoma (20). Conversely, there are retrospective studies that suggested the potential benefit of adjuvant chemotherapy in high grade and advanced stage disease (21,22).…”

Section: Discussionmentioning

confidence: 99%

Olfactory Neuroblastoma: A 15-Year Single Institution Experience

Khademi

Safari

Hosseini

et al. 2015

Rep Radiother Oncol

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“…Nuestros resultados en términos de supervivencia y periodo libre de enfermedad a los 5 años, si estimamos su valor según la curva de Kaplan Meier, son de 74,1% y del 55,6% respectivamente. En los artículos de la literatura el rango de supervivencia a los 5 años se sitúa entre el 50-90% y el periodo libre de enfermedad entre el 45-90% 2,16,17,37,41,42,48,60 . Cabe decir que nuestra población de pacientes se encuentran la mayoría en estadíos avanzados de la enfermedad, 2 estadíos B y 9 en estadíos C de Kadish, por lo que nuestros resultados los consideramos satisfactorios.…”

Section: Discussionunclassified

“…Si tomamos como referencia las series más largas de ENB, el rango varía de un 10 al 32% 2,16,17,37,41,42,48,60 , siendo algunas de ellas de gravedad, no siendo así en nuestra serie (dos osteomielitis crónica del colgajo que se curaron tras la retirada del colgajo y una fístula de LCR que se resolvió tras el sellado del defecto dural con fascia lata).…”

Section: Discussionunclassified

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Estudio retrospectivo de 11 casos de estesioneuroblastomas tratados en el Hospital Santa Creu i Sant Pau entre los años 2000 y 2008 más revisión de la literatura

Muñoz¹,

Tresserras²,

Montserrat³

et al. 2011

Neurocirugía

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Combined modality therapy of esthesioneuroblastoma

Abstract: Multidisciplinary therapy of ENB should be considered, especially for Kadish C and high-grade lesions. Craniofacial resection (CFR), Intensity modulated radiation therapy (IMRT), and chemotherapy should be investigated in a multi-institution trial of ENB.

Cited by 61 publications

References 20 publications

A Retrospective Multicenter Study of Carbon Ion Radiotherapy for Locally Advanced Olfactory Neuroblastomas

A Retrospective Multicenter Study of Carbon Ion Radiotherapy for Locally Advanced Olfactory Neuroblastomas

Olfactory Neuroblastoma: A 15-Year Single Institution Experience

Estudio retrospectivo de 11 casos de estesioneuroblastomas tratados en el Hospital Santa Creu i Sant Pau entre los años 2000 y 2008 más revisión de la literatura

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